Kolorex Advanced Candida Care | 30 Capsules

Kolorex® Advanced Candida Care

What is Kolorex?

Kolorex Advanced Candia Care capsules provide natural herbal support for maintaining healthy levels of the yeast Candida albicans in the body, to help prevent infections like candidiasis and to maintain the important balance in gut microflora.

Why use Kolorex?

Kolorex Advanced Candia Care capsules contain a concentrated natural herbal extract made from Horopito, an ancient New Zealand plant used in traditional medicine and with known antifungal properties. Kolorex Advanced Candia Care capsules provide support for maintaining healthy levels of the yeast fungus Candida albicans in the body, to maintain the important balance in gut microflora and to help prevent overgrowth Candida, which can result in infections like candidiasis or thrush.

What are the Key Benefits of Kolorex?

• Traditional medicinal plant organically grown 
• Provides natural support for maintaining healthy gut flora and normal intestinal Candida levels
• Helps prevent the yeast infection candidiasis (thrush)
• Easy to swallow once a day soft gel capsules containing high potency liquid extract
• Does not contain added colours, flavours, preservatives
• Free of gluten, wheat, dairy/casein, soy, corn, yeast, nuts/peanuts

What is Candida?

Candida is a yeast fungus that normally lives in the body without causing any problems. It is found on the skin and in the moist mucous membranes such as in the intestines, mouth, throat and vagina, as part of our normal body flora. Under certain conditions the yeast becomes overgrown and then becomes a fungal infection known as candidiasis, such as if the skin becomes broken, when taking antibiotics or if you have diabetes or a weakened immune system.

What is Candidiasis (thrush)?

Candidiasis is an infection with the yeast fungus Candida albicans, also known as thrush. The most common Candida infections are:

• Oropharyngeal Candidiasis or oral thrush (mouth and throat) with symptoms including white patches on the tongue and soreness when swallowing
• Vaginal Candidiasis or thrush of the vagina with symptoms including itching, burning sensation, and a white cheese-like discharge
• Cutaneous Candidiasis or candida infection of the skin and nails with symptoms including crumbling nails, red scaly itchy patches of skin, such as between the toes or in folds of skin. 

What is the Intestinal Microflora?

The normal intestinal or gut microflora is made up of many microorganisms including bacteria that help with the digestion of our food, and the yeast fungus Candida albicans, one of the microorganisms that live in balance with the gut community, doing no harm but providing no benefit, known as commensalism. Other microorganisms play a role in helping maintain the integrity of the gut wall and protecting against harmful pathogens. It is well recognised that a healthy gut flora is important for overall health and wellness and depends on a balance between microorganisms that are beneficial and those that are harmful. When the balance is tipped then microorganisms that are beneficial become displaced by the overgrowth of harmful microorganisms, which results in an infection or in other symptoms such as bloating, digestive disturbance and may cause more serious problems like irritable bowel disease. Factors that can tip the balance include poor diet, alcohol, stress, antibiotics and some medications^1.

What are the Ingredients of Kolorex?

Horopito (Pseudowintera colorata):

Horopito is an ancient evergreen shrub belonging to the Winteraceae family and native to New Zealand. It is also known as pepperwood due to the spicy taste of its leaves. For hundreds of years, Horopito has been used a traditional medicinal herb the indigenous Maori for skin diseases, including fungal infection and digestive problems, and the leaves were chewed for toothache. Early European settles also used Horopito for medicinal purposes such as for stomach ache2. This unique New Zealand herb is now grown organically by Forest Herbs Research, a Nelson-based private company dedicated to the production of Horopito as a medicinal herb for treatment and prevention of Candida infections. Horopito plants vary in their antifungal activity and the extract used for Kolorex is made from only the most active strain, which are leaves containing red margins^{2, 3.}

Antifungal properties

The leaves of the Horopito plant contain many bioactive compounds including terpenes, particularly polygodial, a sesquiterpene dialdehyde. The highest concentrations of polygodial were found in the red margined leaves^{2, 3.} The extract used for Kolorex is prepared as an oleoresin, which is a combination of oil and resin that contains a highly concentrated amounts of polygloidal and exists in liquid form^2. Extracts of Horopito leaves containing polygloidal were investigated for their antifungal activity and found to be effective against the yeast fungus Candida albicans that causes candidiasis or thrush^4,also against other fungal pathogens^{4, 5.} The antifungal activity of polygloidal was investigate and found to be primarily due to disruption of the fungal cell membrane causing it to leak its intracellular contents resulting in fungal cell death^{6, 7.}

Clinical studies

Studies in women with recurrent vaginal candidiasis demonstrated that Kolorex is equally effective as the antifungal medication itraconazole, as a treatment for reducing symptoms of candidiasis and preventing further infections by eliminating the yeast. Kolorex was also found to be more effective than itraconazole as maintenance treatment in preventing relapses^{8, 9.}

Other Ingredients:

Kolorex Advanced Candia Care soft gel capsules also contain olive oil, gelatin (bovine source, halal certified), glycerine and purified water.

What are the Contraindications/Interactions of Kolorex?

Do not use if you are pregnant or breastfeeding, and do not give to children, as there is no clinical evidence for safety during pregnancy or in children.
Stop using if you develop any irritation or allergy while taking Kolorex. Always read the label and use as directed and seek advice from your healthcare professional.

What are the Directions for using Kolorex?

Dosage:

Take your Kolorex Advanced Candia Care soft gel capsules once daily, swallowed whole with a glass of water.

References

The following references provide scientific support for the use of this product:

1. Jandhyala SM, Talukdar R, Subramanyam C, Harish Vuyyuru H, Mitnala Sasikala M, Reddy DN Role of the normal gut microbiota. World J Gastroenterol 2015 Aug 7; 21(29): 8787–8803.
2. Forest Herbs Research, Scientific Summary Version 13 (Aug 2016) http://www.kolorex.com/wp-content/uploads/2016/08/FHR-Scientific-Summary-V13-August-2016.pdf 
3. Cooney LJ, van Klink JW, Hughes NM, Perry NB, Schaefer HM, Menzies IJ, Gould KS. Red leaf margins indicate increased polygodial content and function as visual signals to reduce herbivory in Pseudowintera colorata. New Phytol. 2012 Apr;194(2):488-97. 
4. McCallion R.F., Cole A.L.J., Walker J.R.L., Blunt J.W., Munro M.H.G. Antibiotic substances from New Zealand plants. II. Polygodial, an anti-Candida agent from Pseudowintera colorata. Planta Med. 1982;44:134–138.
5. Lee, S.H.; Lee, J.R.; Lunde, C.S.; Kubo, I. In vitro antifungal susceptibilities of Candida albicans and other fungal pathogens to polygodial, a sesquiterpene dialdehyde. Planta Med. 1999, 65, 204–208.
6. Taniguchi, M., Yano, Y., Tada, E., Ikenishi, K., Oi, S., Haraguchi, H., Hashimoto, K. & Kubo, I. (1988). Mode of Action of Polygodial, an Antifungal Sesquiterpene Dialdehyde. Agricultural and Biological Chemistry, 52(61), 1409–1414. 
7. Kubo I., Fujita K., Lee S.H. Antifungal mechanism of polygodial. J. Agric. Food Chem. 2001;49:1607–1611.
8. Kumari A, Bishier MP, Naito Y, Sharma A, Solimene U, Jain S, Yadava H, Minelli E, Tomella C, Marotta F. Protective effect of an oral natural phytonutrient in recurrent vulvovaginal candidiasis: a 12-month study. J Biol Regul Homeost Agents 2011 Oct-Dec;25(4):543-51.
9. Chopra V., Marotta F., Kumari A., Bishier M.P., He F., Zerbinati N., Agarwal C., Naito Y., Tomella C., Sharma A., Solimene U. (2013) Prophylactic strategies in recurrent vulvovaginal candidiasis: a 2-year study testing a phytonutrient vs itraconazole. Journal of Biological Regulators and Homeostatic Agents, 27(3):875-82.