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Good Health Immuno-Biotic Pre + Pro Biotic in One | 30 Vege Capsules

Good Health Immuno-Biotic Pre + Pro Biotic in One | 30 Vege Capsules

$25.65
$25.65
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Good Health Immuno-Biotic Pre + Pro Biotic in One

What is Immuno-Biotic Pre + Pro Biotic in One?

Immuno-Biotic Pre & Pro Biotic in One is a combined probiotic and a prebiotic together in one capsule. The prebiotic provides nutrient for the probiotic, which are live beneficial bacteria, and increases the effectiveness of the probiotic. This combination ensures that the “good” bacteria in our gut flora flourish and optimal balance is restored, which is essential to promote gut health and a strong immune system.

Why use Immuno-Biotic Pre + Pro Biotic in One?

Gut health is essential for overall health and wellness and this includes a gut flora or microbiota (the complete collection of microorganisms that inhabit the gut) containing a balance between “good” bacteria, that provide several health benefits, and potentially pathogenic bacteria that keep the gut immune system on its toes. Immuno-Biotic is a combined probiotic and prebiotic in the same capsule that promotes a balanced microbiota, which can be disrupted by several factors including diet, lifestyle and medications, particularly antibiotics. Immuno-Biotic supports gut health and a strong immune system.

What are the Key Benefits of Immuno-Biotic Pre + Pro Biotic in One?

  • Clinically researched probiotic and prebiotic in the same capsule
  • Contains ingredients that supports the immune system
  • Natural ingredients that support the gut barrier function
  • Suitable for digestive problems or concerns with the immune system
  • Suitable for taking with and after antibiotics, and while travelling
  • Capsules are vegan and gluten and dairy free 
  • Suitable for vegetarians and dairy or gluten intolerances

What is a probiotic?

We coexist with millions of live bacteria and other microorganisms in and on our body, the majority living in our gut, and these microorganisms are collectively known as the microbiota. A probiotic refers to bacteria that live in the intestines and play an active health-promoting role by supporting the digestion of our food and absorption of vital nutrients; also by reducing inflammation due to their inflammatory properties, and by boosting the immune system, due to their immunoregulatory properties1, 2. The most well-known probiotics are Lactobacillus and Bifidobacteria and they begin to develop in the gut of a new-born soon after birth. The balance between probiotic bacteria and harmful bacteria, which together make up the microbiota of our gut, can be affected by several factors. These include diet (high fat and sugar), excess alcohol, ageing, some medication (particularly antibiotics), illness, stress, infection (due enteric pathogens causing gastroenteritis), and lifestyle factors like smoking and lack of exercise. An imbalance in the microbiota can cause health problems, due to digestive issues like lactose intolerance, or an impaired immune system predisposing to infection or to food allergies; while other are more serious such as Inflammatory Bowel Disease (IBD) and Irritable Bowel Syndrome (IBS)3, 4, 5, 6.

What is a prebiotic?

A Prebiotic is a natural substance that cannot be digested and is found in dietary fibre of some fruits and vegetables, and is particularly high in raw food such as raw chicory root, onion, asparagus and banana. They are a food source for probiotic bacteria in the gut and are obtained by fermentation of the fibre by these bacteria. Prebiotics enable probiotic bacteria to flourish, selectively promoting their growth over other bacteria and maintaining the balance between “good” bacteria that provide health benefits and potentially harmful pathogenic bacteria7.

Why is the gut microbiota important for a healthy immune system?

The gut wall contains 75-80% of our entire immune system and a finely tuned balance is maintained between the intestinal immune system and the gut microbiota, which have evolved together to support health and wellbeing. The job of the intestinal immune system is to prevent invasion with pathogenic microorganisms that cause disease, being always at the ready to fight and kill pathogens; while at the same the immune cells must maintain tolerance to many innocuous microorganisms and food substances in the gut. If this balance becomes out of kilter for any reason, the consequences can impact significantly on health and disease outcomes. The immune system can be triggered to respond and this can initiate an inflammatory or allergic response, which can result in diseases of the gut, such as Inflammatory Bowel Disease (IBD), Irritable Bowel Syndrome (IBS), or even predispose to systemic diseases like obesity and diabetes8, 9, 10.

What is an immunomodulator?

The immune system is the body’s natural defence against invasion by environmental pathogens, like bacteria, viruses and parasites, and is a complex process that involves many cell types that produce an array of chemical mediators like cytokines and interferon; also antibodies. The various components of the immune system work together with the aim of recognising foreign invaders from self and destroying the invader. An immunomodulator is a substance (chemical or herbal) that affects the way the immune system works either by stimulating it (immunostimulant) or suppressing it (Immunosuppressant).

What are the Ingredients of Immuno-Biotic Pre + Pro Biotic in One?

Each capsule of Immuno-Biotic contains:
  • Yeast dried fermentate EpiCor® 250mg
  • Bacillus coagulans 1 billion CFU (Colony Forming Units)
  • L-Glutamine 100mg
  • Zinc (as Gluconate) 5mg

Key Ingredients:

Yeast dried fermentate EpiCor®:

EpiCor® is a dried fermentation product of the yeast Saccharomyces cerevisiae that is not a prebiotic by definition. However, it has been shown to act like a prebiotic using the SHIME model (Simulator of the Human Intestinal Microbial Ecosystem), which is a dynamic in vitro model used to study how human digestion system works throughout the gastrointestinal tract, including the role of the gut microbiota. This model was used to demonstrate that EpiCor® increases the numbers of probiotic bacteria like bifidobacteria and lactobacilli; and has immunomodulatory anti-inflammatory properties11, 12. EpiCor® also stimulates the production of the short chain fatty acid butyrate, an end product of fermentation of dietary fibre that takes place in the colon. Butyrate plays an important role in gut health by acting as an energy source for gut epithelial cells, supporting the gut barrier function and boosting the gut immune system13, 14. Several clinical studies have demonstrated that EpiCor® boosts the immune response, and has antioxidant and anti-inflammatory properties15, 16. EpiCor® also improves gastrointestinal discomfort caused by bloating and constipation17, reduces nasal congestion induced by allergic rhinitis18, and reduces cold and flu-like symptoms19.

Bacillus coagulans:

Bacillus coagulans Unique IS2 is a lactic acid producing probiotic bacteria that differs from other probiotic bacteria like Lactobacillus and Bifidobacteria, as it produces reproductive spores (and was previously known as Lactobacillus sporogenes) that enable the bacteria to remain dormant in unfavourable conditions20. The cell wall of this strain of Bacillus coagulans is highly resistant to fluctuations in temperature and pH levels, including high levels of stomach acid. These characteristics enable it to survive in conditions that other probiotic bacteria would not be able to. Also, the cell wall of Bacillus coagulans has been shown to have immunomodulating and anti-inflammatory properties21, 22, 23. Once the spores reach the intestines, they germinate and replicate to promote health benefits known for probiotics. Probiotics like Bacillus coagulans can also be found in fermented food like sauerkraut, kimchi (salted fermented vegetables) and some yogurts.

L-Glutamine:

Glutamine is a free amino acid that plays an important role in intestinal health. It is utilised by the intestines as a key nutrient, where it supports intestinal barrier function by promoting tight junctions of the gut lining to prevent leaky gut, which is when toxins, pathogens or food substances cross the gut barrier into the blood circulation. This can lead to the pathogenesis of various diseases both local and systemic. Glutamine also supports repair of the gut lining by promoting enterocyte proliferation (columnar cells of the epithelium lining the intestines), and it also helps protect the gut mucosa by supressing inflammatory signals, regulating cellular stress responses and apoptosis (programmed cell death) and boosting the gut immune system24. Glutamine is an important nutrient for cells and tissues involved in responding to stress and trauma25 and there is evidence that some intestinal diseases like Inflammatory Bowel Disease (IBD) are associated with low levels of glutamine and would benefit from glutamine supplementation24.

Zinc:

Zinc is an essential micronutrient and plays an important role in many biological processes including growth, tissue and wound repair and immunity and is particularly vital for development and normal functioning of the immune system26, 27. Zinc is not stored in the body; it is obtained from the diet and absorbed in the small intestine. It is a vital component in functioning of some enzymes required for metabolism and for gene transcription, and a deficiency in zinc can result in dysfunction of the immune and lead to increased risk of infection and inflammation. Low levels of zinc are commonly associated with Inflammatory Bowel Disease (IBD), which may be due to inadequate zinc intake or poor absorption from the gastrointestinal tract28, 29.

What are the Contraindications/Interactions of Immuno-Biotic Pre + Pro Biotic in One?

There are no documented contraindications or interactions within the recommended dosage. However, you should always check the ingredients for known allergies and to ensure you do not have any allergies or sensitivities to these ingredients. Stop using if you develop any irritation or allergy while taking Immuno-Biotic. Always read the label and use as directed or seek advice from your healthcare professional.

What are the Directions for using Immuno-Biotic Pre + Pro Biotic in One?

Dosage:

For acute conditions take two capsules daily with food.
For maintenance, take one capsule daily with food.

Product Size

30 Vege Capsules

References

The following references provide scientific support for the use of this product:

  1. Clemente JC, Ursell LK, Parfrey LW, Knight R. The Impact of the Gut Microbiota on Human Health: An Integrative View. Cell 2012, 148 issue 6, 1258-70
  2. O’Hara AM, Shanahan F. The gut flora as a forgotten organ. EMBO Reports 207 7(7) 688-693.
  3. Orel R, Kamhi Trop T. Intestinal microbiota, probiotics and prebiotics in inflammatory bowel disease. World J Gastroenterol. 2014 Sep 7;20(33):11505-24
  4. Cresci GA, Bawden E. Gut Microbiome: What We Do and Don't Know. Nutr Clin Pract 2015 Dec;30(6):734-46. 
  5. Cai J, Zhao C, Du Y, Zhang Y, Zhao M, Zhao Q. Comparative efficacy and tolerability of probiotics for antibiotic-associated diarrhea: Systematic review with network meta-analysis. United European Gastroenterol J2018 Mar;6(2):169-180. 
  6. Hungin APS, C. Mulligan C, Pot B, . Whorwell P, Agreus L, Fracasso P, et al. Systematic review: probiotics in the management of lower gastrointestinal symptoms in clinical practice – an evidence based international guide. Aliment Pharmacol Ther 2013 Oct; 38(8): 864–886.
  7. Quigley E. Prebiotics and probiotics; modifying and mining the microbiota. Pharm Res. 2010, Vol 61 issue 3, 213-218.
  8. Cader MZ, Kaser A. Recent advances in inflammatory bowel disease: mucosal immune cells in intestinal inflammation. Gut 2013 Nov;62(11):1653-64. 
  9. Lei YM, Nair L, Alegre ML. The interplay between the intestinal microbiota and the immune system. Clin Res Hepatol Gastroenterol 2015 Feb;39(1):9-19. 
  10. Bischoff C. 'Gut health': a new objective in medicine? BMC Medicine20119:24
  11. Van den Abbeele P, Roos S, Eeckhaut V, MacKenzie DA, Derde M, et al. Incorporating a mucosal environment in a dynamic gut model results in a more representative colonization by lactobacilli. Microb Biotechnol 2012 Jan;5(1):106-15. 
  12. Possemiers S, Pinheiro I, Verhelst A, Van den Abbeele P, Maignien L, Laukens D, et al. A dried yeast fermentate selectively modulates both the luminal and mucosal gut microbiota and protects against inflammation, as studied in an integrated in vitro approach. J Agric Food Chem. 2013;61:9380–9392. 
  13. Vinolo MAR, Rodrigues HG, Nachbar RT, Curi R. Regulation of inflammation by short chain fatty acids. Nutrients. 2011;3:858–76.
  14. Rivière A, Selak M, Lantin D, Leroy F, De Vuyst L. Bifidobacteria and Butyrate-Producing Colon Bacteria: Importance and Strategies for Their Stimulation in the Human Gut. Front Microbiol 2016; 7: 979.
  15. Jensen GS, Redman KA, Benson KF, Carter SG, Mizner MA, Reeves SG, Robinson LE: Antioxidant bioavailability and rapid immune-modulating effects after consumption of a single acute dose of a high-metabolite yeast immunogen: Results of a Placebo-Controlled Double-Blinded Crossover Pilot Study. J Med Food 2011;14:1002–1010
  16. Jensen GS, Carter SG, Reeves SG, Robinson LE, Benson KF. Anti-inflammatory properties of a dried fermentate in vitro and in vivo. J Med Food. 2015 Mar;18(3):378-84. 
  17. Pinheiro I, Robinson L, Verhelst A, Marzorati M, Winkens B, den Abbeele PV, Possemiers S. A yeast fermentate improves gastrointestinal discomfort and constipation by modulation of the gut microbiome: results from a randomized double-blind placebo-controlled pilot trial. BMC Complement Altern Med. 2017 Sep 4;17(1):441. 
  18. Moyad MA, Robinson LE, Kittelsrud JM, Reeves SG, Weaver SE, Guzman AI, Bubak ME. Immunogenic yeast-based fermentation product reduces allergic rhinitis-induced nasal congestion: a randomized, double-blind, placebo-controlled trial. Adv Ther. 2009 Aug;26(8):795-804. 
  19. Moyad MA, Robinson LE, Zawada ET, Kittelsrud J, Chen DG, Reeves SG, Weaver S. Immunogenic yeast-based fermentate for cold/flu-like symptoms in nonvaccinated individuals. J Altern Complement Med 2010 Feb;16(2):213-8
  20. Sudha, R. M., Chauhan, P., Dixit, K., Babu, S. and Jamil, K. (2011). Molecular typing and probiotic attributes of a new strain of Bacillus coagulans Unique IS-2: a potent biotherapeutic agent. Genetic engineering and Biotechnology Journal GEBJ-7
  21. Hong HA, Duc le H, Cutting SM. The use of bacterial spore formers as probiotics. FEMS microbiology reviews. 2005;29(4):813–35. Epub 2005/08/17.
  22. Benson KF, Redman KA, Carter SG, et al. Probiotic metabolites from Bacillus coagulans Ganeden BC30™ support maturation of antigen-presenting cells in vitro. World J Gastroenterol. 2012;18(16):1875–1883
  23. Jensen GS, Cash HA, Farmer S, Keller D. Inactivated probiotic Bacillus coagulans GBI-30 induces complex immune activating, anti-inflammatory, and regenerative markers in vitro. J Inflamm Res 2017 Aug 7;10:107-117. 
  24. Kim MH, Hyeyoung Kim H. The Roles of Glutamine in the Intestine and Its Implication in Intestinal Diseases. Int J Mol Sci 2017 May; 18(5): 1051
  25. Soeters P.B., Grecu I. Have we enough glutamine and how does it work? A clinician’s view. Ann. Nutr. Metab. 2012;60:17–26.
  26. Prasad AS. Zinc in Human Health: Effect of Zinc on Immune Cells, Mol Med 2008 May-Jun; 14(5-6): 353–357.
  27. Park JS, Choi J, Kwon JY, Jung KA, Yang CW, Park SH, Cho ML. A probiotic complex, rosavin, zinc, and prebiotics ameliorate intestinal inflammation in an acute colitis mouse model. J Transl Med. 2018 Feb 21;16(1):37. 
  28. Alkhouri RH, Hashmi H, Baker RD, Gelfond D, Baker SS. Vitamin and mineral status in patients with inflammatory bowel disease. J Pediatr Gastroenterol Nutr. 2013;56:89–92
  29. Clarke K, Chintanaboina J. Allergic and Immunologic Perspectives of Inflammatory Bowel Disease. Clin Rev Allergy Immunol. 2018 May 12.