{"product_id":"go-healthy-go-turmeric-for-joints-1-a-day","title":"Go Healthy Go Turmeric For Joints 1-A-Day","description":"\u003ch2\u003eGo Healthy Go Turmeric For Joints 1-A-Day\u003c\/h2\u003e\r \u003ch3\u003eWhat is Go Turmeric For Joints?\u003c\/h3\u003e\r \u003cp\u003eGo Turmeric For Joints is a combination of high strength turmeric, and a selected blend of natural herbs with properties that promote joint health and joint mobility, and provide support for sore, stiff joints associated with arthritic joint diseases.  \u003c\/p\u003e\r \u003ch3\u003eWhy use Go Turmeric For Joints?\u003c\/h3\u003e\r \u003cp\u003eArthritic joint diseases can be due to different causes but result in the same range of symptoms including pain, inflammation, stiffness and swelling, leading to reduced mobility of the affected joint.  Go Turmeric For Joints is a combination of high strength turmeric, and a selected blend of natural herbs and spices with properties that work in synergy to promote joint health and joint mobility, and provide support for sore, stiff joints associated with arthritic joint diseases.  \u003c\/p\u003e\r \u003ch3\u003eWhat are the Key Benefits of Go Turmeric For Joints?\u003c\/h3\u003e\r \u003cul\u003e\r     \u003cli\u003eTraditional medicinal plant formula \u003c\/li\u003e\r     \u003cli\u003ePromotes joint health\u003c\/li\u003e\r     \u003cli\u003eSupports joint mobility to reduce stiffness and increase mobility\u003c\/li\u003e\r     \u003cli\u003eFast acting formula with natural absorption enhancer\u003c\/li\u003e\r     \u003cli\u003eVegeCapsules are all plant based\u003c\/li\u003e\r     \u003cli\u003eDoes not contain sugar or artificial sweeteners\u003c\/li\u003e\r     \u003cli\u003eDoes not contain added colours, flavours, preservatives, gluten, wheat or dairy\u003c\/li\u003e\r \u003c\/ul\u003e\r \u003ch4\u003eWhat is an arthritis?\u003c\/h4\u003e\r \u003cp\u003eArthritis is a chronic inflammatory disease of the joints.  Although there are several forms of arthritis, the symptoms are similar and include pain, inflammation, and loss of mobility of the affected joint.  The most common forms of arthritis are osteoarthritis and rheumatoid arthritis.  Osteoarthritis is a degenerative joint disease associated with increasing age and is caused by wear and tear of the joints, resulting in breakdown of the protective cartilage at the end of the bones.  Rheumatoid arthritis is a destructive systemic autoimmune disease, where the immune system attacks the joint lining or synovium, causing pain, inflammation and swelling of the joint.  \u003c\/p\u003e\r \u003ch4\u003eWhat are inflammatory mediators?\u003c\/h4\u003e\r \u003cp\u003eInflammatory mediators are substances that promote inflammation by various mechanisms and are the target of anti-inflammatory herbs and medications. \u003c\/p\u003e\r \u003ch5\u003eProstaglandins and leukotrienes\u003c\/h5\u003e\r \u003cp\u003eProstaglandins and leukotrienes are eicosanoids that are synthesised from arachidonic acid, released from the cell membrane by the action of a phospholipase enzyme.  Arachidonic acid then enters one of two biochemical pathways.  Prostaglandins are produced by the action of the cyclooxygenase enzyme (COX), which exists in two forms.  COX-1 is constitutively expressed by most cell types, which means it is always active and produces prostaglandins that carry out essential tasks like protecting gastric mucosa cells.  COX-2 is an inducible enzyme, which means it is only produced during the inflammatory process and produces only inflammatory prostaglandins.  The COX enzymes are the target of non-steroidal anti-inflammatory drugs (NSAIDs) and the more specific NSAIDs that are used for arthritis, target COX-2.  Leukotrienes are inflammatory mediators produced by cells of the immune system.  The arachidonic acid cleaved from the cell membrane enters a different pathway and is metabolised by the enzyme 5-lipoxygenase (5-LO) into leukotrienes. \u003c\/p\u003e\r \u003ch5\u003eCytokines\u003c\/h5\u003e\r \u003cp\u003eCytokines are small proteins produced by various cells including chondrocytes (cartilage cells) and synovial cells, which are cells of joint tissue; also cells immune system, and have specific effects including promoting the inflammatory process.  They include the interleukins, particularly Interleukin-1 (IL-1) and Interleukin-6 (IL-6) and Tumor Necrosis Factor α (TNF α).  These cytokines have destructive effects on joint tissues by increasing production of degradative enzymes such as metalloproteinases and collagenases.  Inflammatory cytokines are induced during the inflammatory process by activation of inflammatory nuclear factor (NF-kB), a transcription factor that controls the expression of proinflammatory cytokine genes. \u003c\/p\u003e\r \u003ch4\u003eWhat is bioavailability?\u003c\/h4\u003e\r \u003cp\u003eBioavailability is an indication of the amount of a substance taken orally into the body that is absorbed, reaches the blood circulation and is distributed to the target tissue unchanged and in active form.  Many drugs are metabolised by enzymes in the liver and intestinal wall and this reduces their bioavailability.  Some herbal medicines like curcumin in Turmeric and boswellic acids in Boswellia, have low bioavailability as they are lipophilic (fat but not water soluble) and highly metabolised before reaching their targets.  However, their bioavailability can be increased, for example by using delivery mechanisms like liposomes, taking together with a high fat meal, adding phosphatidylcholine (lecithin), which is a lipid and the main component of cell membranes, and including natural ingredients like piperine (see below).  \u003c\/p\u003e\r \u003ch4\u003eWhat is synergy?\u003c\/h4\u003e\r \u003cp\u003eThe concept of synergy applied to drugs or phytochemicals (natural plant compounds) is that two or more compounds have an effect that is greater than the effect of one of those compounds alone.  Many phytochemicals have synergistic interactions due to complementary and overlapping mechanisms of actions and these can influence the effectiveness or bioavailability of the phytochemical1,2,3.  For example, boswellic acid found in Boswellia and curcumin found in turmeric have synergistic effects in reducing pain related symptoms of osteoarthritis\u003csup\u003e4.  \u003c\/sup\u003e\u003c\/p\u003e\r \u003ch4\u003e\r What is the WOMAC pain score?\u003c\/h4\u003e\r \u003cp\u003e\r The Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) is a widely used proprietary standard questionnaire and scoring system developed by Western Ontario and McMaster Universities for assessing levels of pain and disability due to osteoarthritic.  WOMAC is self-administered and has 24 items divided into 3 subscales: pain (5 items), stiffness (2 items) and physical function (17 items).\u003c\/p\u003e\r \u003ch3\u003e\r What are the Ingredients of Go Turmeric For Joints?\u003c\/h3\u003e\r \u003cp\u003e\r Go Turmeric For Joints is a synergistic blend of selected herbal extracts, some of which have been used in traditional medicine for thousands of years to support general health and wellbeing.  \u003c\/p\u003e\r \u003ch5\u003e\r Each capsule of Go Turmeric For Joints contains the following ingredients:\u003c\/h5\u003e\r \u003cul\u003e\r     \u003cli\u003eTurmuric (Curcuma longa)\t\t\t21,000mg \u003c\/li\u003e\r     \u003cli\u003eBoswellia (Boswellia sacra)\t\t\t1000mg\u003c\/li\u003e\r     \u003cli\u003eGinger (Zingiber officinale)\t\t\t150mg\u003c\/li\u003e\r     \u003cli\u003eBromelain\t\t\t\t\t\t30mg \u003c\/li\u003e\r     \u003cli\u003eCelery (Apium graveolens)\t\t\t150mg\u003c\/li\u003e\r     \u003cli\u003eDevils Claw (Harpagophytum procumbens)\t100mg\u003c\/li\u003e\r     \u003cli\u003eWhite Willow (Salix alba)\t\t\t\t100mg\u003c\/li\u003e\r     \u003cli\u003eBlack Pepper \/ BioPerine®\t\t\t6mg (equivalent to 120mg black pepper fruit (Piper nigrum)and Piperine 5.7mg)\u003c\/li\u003e\r \u003c\/ul\u003e\r \u003ch5\u003eTurmeric \u003cem\u003e(Curcuma longa):\u003c\/em\u003e\n\u003c\/h5\u003e\r \u003cp\u003e\r Turmeric is a flowering plant belonging to the ginger family (Zingiberaceae) that is native to India and Southeast Asia.  In traditional Indian (Ayurvedic) and Chinese medicine turmeric has been used for centuries for treating infections, dysentery, arthritis, fevers and digestive diseases.  Turmeric has many biological effects including antioxidant, antimicrobial, anti-inflammatory, anticancer, wound healing and gastroprotective, and is used for treating and preventing various conditions including liver disease, diabetes, cardiovascular diseases, arthritis, urinary and gastrointestinal tract infections and gastric ulcers.  The main pharmacologically active component in extract of Turmeric rhizomes (horizontal underground stem) is the polyphenol curcumin that is also used as a spice and yellow pigment \u003csup\u003e5, 6, 7, 8. \u003c\/sup\u003e Curcumin is known to be unstable, with poor absorption and low bioavailability and is rapidly metabolised.  Since Curcumin has many well documented medicinal properties, several options for improving bioavailability have been investigated including the use of phytosomes, which is a complex of a natural ingredient like curcumin with a phospholipid usually phosphatidylcholine (lecithin)9.  Piperine, the major pharmacologically active component in both black and long pepper, has been shown to significantly increase bioavailability of curcumin\u003csup\u003e10, 11. \u003c\/sup\u003e The anti-inflammatory activity of curcumin has been studied in several experimental models and the mechanisms involved include inhibition of the COX enzyme, specifically COX-2 that is induced during the inflammatory response and produces inflammatory prostaglandins; Inhibition of production of the proinflammatory cytokines IL-1, IL-6 and TNF α from specific immune cells; and inhibiting the activation of inflammatory nuclear factor (NF-kB), a transcription factor that controls the expression of proinflammatory cytokine genes\u003csup\u003e8, 12, 13.  \u003c\/sup\u003eCurcumin extract was also found to inhibit joint destructive enzymes like collagenase and metalloproteinase in rheumatoid arthritis8, Several clinical studies have demonstrated that various turmeric\/curcumin extracts are effective in relieving symptoms of arthritis (osteoarthritis and rheumatoid arthritis), using clinical and biochemical measures including a standard scoring systems for symptom improvement (WOMAC), levels of inflammation markers such as inflammatory mediators, and using a treadmill walking test.  Turmeric was found to be effective in providing symptom relief and was as effective as other supplements like chondroitin and glucosamine; also, traditional non-steroidal anti-inflammatory medications in reducing pain and inflammation, as well as improving joint mobility\u003csup\u003e12, 14, 15.\u003c\/sup\u003e  There is also clinical and preclinical evidence that turmeric has analgesic properties that can reduce the pain level in the osteoarthritic joints\u003csup\u003e16.  \u003c\/sup\u003e\u003c\/p\u003e\r \u003ch5\u003e\r Boswellia\u003cem\u003e (Boswellia serrata):\u003c\/em\u003e\n\u003c\/h5\u003e\r \u003cp\u003e\r Boswellia, also known as Indian frankincense, is a resin extracted from the bark of the Boswellia serrata tree belonging to the Burseraceae family that is native to India.  In traditional Indian Ayurvedic medicine, Boswellia gum was used to treat several inflammatory diseases including inflammation of the skin, eye, gums, gastrointestinal tract and joints as well as respiratory inflammatory disorders such as asthma and is still used to treat chronic inflammatory diseases such as chronic ulcerative colitis, rheumatoid arthritis, Crohn's disease, and bronchial asthma\u003csup\u003e17. \u003c\/sup\u003e Boswellia resin has potent anti-inflammatory activity, as well as anti-arthritic and analgesic activity, due to the presence of boswellic acids, which are pentacyclic triterpenes, and the most active boswellic acid in terms of anti-inflammatory activity has been identified as acetyl-11-keto-beta-boswellic acid (AKBA)\u003csup\u003e18, 19.\u003c\/sup\u003e  However, the boswellic acids have low bioavailability due to poor absorption from the intestines, which can be increased by various strategies, such as using a lecithin delivery system, formulating with phospholipids and taking with a high fat meal\u003csup\u003e20, 21.\u003c\/sup\u003e  Based on in vitro and animal studies, the mechanism of action for the anti-inflammatory activity is thought to be primarily by blocking the production of proinflammatory leukotrienes by inhibition of 5-lipoxygenase (5-LO), the enzyme regulating leukotriene synthesis by specific cells of the immune system.  Another anti-inflammatory mechanism identified is inhibition of the COX enzyme that produces inflammatory prostaglandins\u003csup\u003e17.  \u003c\/sup\u003eOutcomes of several clinical studies have demonstrated that various extracts of Boswellia can improve pain, inflammation and joint mobility in osteoarthritis of the knee\u003csup\u003e22, 23, 24, 25.\u003c\/sup\u003e  A Cochrane review of clinical trials confirmed these findings\u003csup\u003e26.\u003c\/sup\u003e  Boswellia resin extract also reduced the amount of matrix metalloproteinase, a cartilage degrading enzyme in the synovial fluid, within the joint cavity\u003csup\u003e22, 23.  \u003c\/sup\u003e\u003c\/p\u003e\r \u003ch5\u003e\r Ginger \u003cem\u003e(Zingiber officinale):\u003c\/em\u003e\n\u003c\/h5\u003e\r \u003cp\u003e\r Ginger is a flowering plant belonging to the Zingiberaceae family that originated from in India and Southern Asia.  The root of the ginger plant is used as a spice in cooking and for its medicinal properties and has been used in traditional Indian and Chinese medicine for digestive problems and for treating inflammatory diseases such as arthritis.  The pharmacologically active compounds in Ginger include gingerols, shogaols, zingerone, and paradol.  Gingerol is converted to zingerone during the drying process of ginger root and these compounds have been found to have potent antioxidant, anti-inflammatory and antiarthritic properties\u003csup\u003e27, 28.\u003c\/sup\u003e  Animal and in vitro studies have shown that ginger exerts its anti-inflammatory effects by inhibition of COX-1 and COX-2 enzymes, reducing production of inflammatory prostaglandins; and inhibition of 5-lipoxygenase (5-LOX), reducing production of inflammatory leukotrienes; also inhibition of the inflammatory nuclear factor (NF-kB), reducing expression of proinflammatory cytokine genes\u003csup\u003e27, 28, 29. \u003c\/sup\u003e Other compound found in ginger essential oils also have anti-inflammatory properties30.  Clinical studies have demonstrated ginger reduces pain due to osteoarthritis that is as effective as the NSAID ibuprofen\u003csup\u003e31.\u003c\/sup\u003e  In a clinical study of patients with osteoarthritis of the knee an ayurvedic formulation including ginger was found to be as effective as glucosamine and celecoxib a specific COX-2 inhibitor, as measured by standard pain and joint function scores (WOMAC)\u003csup\u003e32.  \u003c\/sup\u003eA review of clinical trials using ginger to treat pain and functional disability of the affected joint, concluded that the ginger was an effective alternative treatment for symptomatic treatment of osteoarthritis\u003csup\u003e33.  \u003c\/sup\u003e\u003c\/p\u003e\r \u003ch5\u003e\r Bromelain:\u003c\/h5\u003e\r \u003cp\u003e\r Bromelain is an extract derived from the stem and fruit of the pineapple plant (Ananas comosus) belonging to the Bromeliaceae family and native to South America and contains a mixture of proteolytic enzymes.  Bromelain is used in traditional medicine for its many bioactive properties including inhibiting tumour growth, antithrombotic (inhibiting platelet aggregation and clot formation), fibrinolytic for skin debridement, promotion of wound healing, and anti-inflammatory.  Medicinal uses for bromelain based on clinical studies includes treating cardiovascular disease, relieving symptoms of osteoarthritis, treating bacterial diarrhoea, limiting tumour growth, and debridement of burns.  Bromelain is readily absorbed into the intestines without loss of bioactivity and is considered a useful dietary supplement as an oral enzyme.  \u003csup\u003e43, 35, 36 \u003c\/sup\u003eThe anti-inflammatory properties of bromelain were investigated using colon biopsies from inflamed tissue of patients with ulcerative colitis and demonstrated that bromelain inhibits secretion of inflammatory cytokines\u003csup\u003e37.\u003c\/sup\u003e  The outcome of a review of clinical studies indicated that bromelain helped relieve inflammatory symptoms of osteoarthritis\u003csup\u003e38, \u003c\/sup\u003eand found to be as effective as the NSAID diclofenac using a standard clinical standard scoring system for symptom improvement in osteoarthritis of the knee (WOMAC)\u003csup\u003e39.  \u003c\/sup\u003eThese findings were confirmed in a study using a combination of bromelain with two other herbal extracts known to have analgesic and anti-inflammatory properties (Turmeric and Devil’s claw) that indicated symptom improvement for osteoarthritis\u003csup\u003e40.\u003c\/sup\u003e  A combination of bromelain, the enzyme trypsin and the flavonoid rutinoid was found to be as effective in symptom improvement for osteoarthritis as the NSAID diclofenac\u003csup\u003e41, \u003c\/sup\u003eand more effective when combined with diclofenac than diclofenac alone\u003csup\u003e42.   \u003c\/sup\u003e\u003c\/p\u003e\r \u003ch5\u003e\r Celery\u003cem\u003e (Apium graveolens):\u003c\/em\u003e\n\u003c\/h5\u003e\r \u003cp\u003e\r Celery is a perennial plant belonging to the Apiaceae family that is native to Europe and the tropical and subtropical regions of Africa and Asia and is grown as a vegetable and as a medicinal plant.  The seeds of the Celery plant were used in traditional medicine to treat painful arthritic joints and reduce inflammation.  In contemporary herbal medicine, celery is still used to treat arthritic pain; also to treat gout, rheumatic disorder, liver disease, amongst other disorders, due to its anti-inflammatory, antioxidant, analgesic, anti-ulcer, diuretic, hepatoprotective, antibacterial, lipid lowering and glucose regulating properties\u003csup\u003e43, 44.  \u003c\/sup\u003eThe pharmacologically active components in celery seed include, coumarins, glycosides, flavonoids, phenolic acids, tannins, volatile oils, alkaloids, sterols, triterpenes and vitamins A and C\u003csup\u003e43, 45.\u003c\/sup\u003e  Animal models have demonstrated anti-inflammatory activity of celery seed extract for gastrointestinal inflammation and arthritis\u003csup\u003e46, 47, 48.\u003c\/sup\u003e  Celery extract was found to be effective in reducing inflammation that was comparable to standard NSAIDs like aspirin, ibuprofen, and naproxen in suppressing arthritis\u003csup\u003e46.  \u003c\/sup\u003e\u003c\/p\u003e\r \u003ch5\u003e\r Devils Claw (Harpagophytum procumbens):\u003c\/h5\u003e\r \u003cp\u003e\r Devil’s Claw is a flowering plant belonging to the Pedaliaceae family that is native to Southern Africa and named after its hooked fruit.  Devil’s Claw has been used in traditional herbal medicine to treat inflammatory conditions of the joints and muscles, including arthritis, lower back pain and inflammation of the muscles and tendons.  The pharmacologically active components of Devil’s Claw include iridoid glycosides, particularly harpagoside\u003csup\u003e49, 50.\u003c\/sup\u003e  Animal and in vitro studies have demonstrated anti-inflammatory and analgesic properties and indicated that the effects are due to inhibition of inflammatory mediators, particularly prostaglandins and leukotrienes49, \u003csup\u003e51.\u003c\/sup\u003e  An in vitro model of inflammation in osteoarthritis using human chondrocytes, demonstrated that harpagoside inhibited the expression of various inflammatory cytokines52.  Several clinical studies have indicated a role for Devil’s Claw in treating various forms of musculoskeletal pain including osteoarthritis and lower back pain\u003csup\u003e49, 50, 53, 54.  \u003c\/sup\u003e\u003c\/p\u003e\r \u003ch5\u003e\r White Willow\u003cem\u003e (Salix alba):\u003c\/em\u003e\n\u003c\/h5\u003e\r \u003cp\u003e\r White willow is a large deciduous tree belonging to the Salicaceae family that is native to Europe and parts of Asia.  The bark of the willow tree has been used in many ancient cultures to relieve pain, fever and inflammation and is used in herbal medicine as an analgesic for osteoarthritis and lower back pain.  The main pharmacologically active ingredient in willow bark is salicin, from which aspirin can be extracted.  Other active compounds include other salicylates, polyphenols and flavonoids alkaloids, tannins and glycosides.  Several in vitro and animal studies have demonstrated analgesic and anti-inflammatory activity of willow bark extract that is due reducing inflammatory mediators including prostaglandins and cytokines like tumour TNF- α\u003csup\u003e55, 56, 57.\u003c\/sup\u003e  Although outcomes were not consistent, some clinical studies demonstrated that willow bark extract reduced pain of osteoarthritis using two standard observational measures for arthritic pain and function (WOMAC and VAS)\u003csup\u003e58, 59, 60.  \u003c\/sup\u003e\u003c\/p\u003e\r \u003ch5\u003e\r Black pepper \u003cem\u003e(Piper nigrum):\u003c\/em\u003e\n\u003c\/h5\u003e\r \u003cp\u003e\r Black pepper is a flowering vine belonging to the Piperaceae family that is native to Southern India and grown for its fruit.  The peppercorn is the dried fruit of the black pepper and is used as a spice in cooking and also in traditional herbal medicine particularly Ayurvedic (traditional Indian herbal medicine) for reducing inflammation, improving digestion, relieving pain and treating asthma.  The major pharmacologically active component in black pepper is piperine, an alkaloid that gives pepper its pungent properties and has many bioactive properties including anti-inflammatory, by inhibiting production of inflammatory cytokines, antioxidant by acting as a free radicle scavenger, promoting digestion by stimulating pancreatic digestive enzymes and reducing the time food remains in the intestines, and inhibiting enzymes that metabolise drugs in the liver.  Piperine also has anti-cancer and anti-ulcer properties61, 62, 63, 64.  Piperine is an effective bioavailability enhancer and is used to improve the bioavailability of several prescription drugs and phytochemicals65, 66.  Piperine has several mechanisms of action that enhance bioavailability.  These include improving absorption from the intestines by stimulating transporter proteins and inhibiting elimination of the drug\/phytochemical from cells, so that it is active for longer.  Piperine also inhibits specific enzymes in the intestines and liver that metabolise drugs, particularly UDP-glucuronyl transferase and arylhydrocarbon hydroxylase; also, cytochrome P-450 isoforms, that are responsible for metabolism of drugs when they pass through the liver after absorption (first pass metabolism).  This first pass metabolism results in loss of bioavailability of many drugs61, 63, 66.  Curcumin in Go Turmeric For Joints has low bioavailability due to poor absorption from the intestines and metabolism in the liver.  Piperine significantly increased the bioavailability of curcumin when given to rats and healthy human volunteers together with curcumin\u003csup\u003e10, 11.   \u003c\/sup\u003e\u003c\/p\u003e\r \u003ch3\u003e\r What are the Contraindications\/Interactions of Go Turmeric For Joints?\u003c\/h3\u003e\r \u003cp\u003e\r You should always check the ingredients for known allergies and to ensure you do not have any allergies or sensitivities to these ingredients.  Stop using if you develop any irritation or allergy while taking Go Turmeric For Joints.  Always read the label and use as directed or seek advice from your healthcare professional.\u003c\/p\u003e\r \u003ch4\u003e\r Caution:\u003c\/h4\u003e\r \u003cp\u003e\r If you are taking prescription medicines you should check with your doctor before using Go Turmeric For Joints.  Bromelain in Go Turmeric For Joints may affect absorption of some medications. \u003c\/p\u003e\r \u003ch5\u003e\r Do not use if:\u003c\/h5\u003e\r \u003cul\u003e\r     \u003cli\u003eyou are pregnant or while breast-feeding\u003c\/li\u003e\r     \u003cli\u003eyou are taking anticoagulants like warfarin or anti-platelet medication like clopidogrel or aspirin (blood-thinning medications) as turmeric and willow bark can prolong bleeding\u003c\/li\u003e\r     \u003cli\u003eyou are allergic to pineapple, as bromelain is derived from pineapples\u003c\/li\u003e\r \u003c\/ul\u003e\r \u003ch5\u003e\r Side effects:\u003c\/h5\u003e\r \u003cp\u003e\r Turmeric and Bromelain can cause diarrhoea, nausea and flatulence, and Devil’s claw can cause side effects including diarrhoea, abdominal pain, and skin reactions. \u003c\/p\u003e\r \u003ch3\u003e\r What are the Directions for using Go Turmeric For Joints?\u003c\/h3\u003e\r \u003ch5\u003eAdults:\u003c\/h5\u003e\r \u003cp\u003eTake one VegeCapsule of Go Turmeric For Joints once daily with food. \u003c\/p\u003e\r \u003ch3\u003eProduct Size\u003c\/h3\u003e\r \u003cp\u003e30 \u0026amp; 60 Vegetable Capsules\u003c\/p\u003e\r \u003ch3\u003e\r References\u003c\/h3\u003e\r \u003ch5\u003e\r The following references provide scientific support for the use of this product:\u003c\/h5\u003e\r \u003col\u003e\r     \u003cli\u003ePhan MAT, Paterson J, Bucknall M, Arcot J.  Interactions between phytochemicals from fruits and vegetables: Effects on bioactivities and bioavailability. Crit Rev Food Sci Nutr.2018 May 24;58(8):1310-1329. \u003c\/li\u003e\r     \u003cli\u003eDragos D, Gilca M, Gaman L, Vlad AIosif L, Stoian I, Lupescu O.  Phytomedicine in Joint Disorders. Nutrients.2017 Jan 16;9(1). pii: E70. \u003c\/li\u003e\r     \u003cli\u003eEfferth T, Koch E.  Complex interactions between phytochemicals. The multi-target therapeutic concept of phytotherapy.  Curr Drug Targets.2011 Jan;12(1):122-32.\u003c\/li\u003e\r     \u003cli\u003eHaroyan AS, Mukuchyan V, Mkrtchyan N, Minasyan N, Gasparyan S, et al. Efficacy and safety of curcumin and its combination with boswellic acid in osteoarthritis: a comparative, randomized, double-blind, placebo-controlled study. BMC Complement Altern Med 2018; 18: 7.\u003c\/li\u003e\r     \u003cli\u003eAmalraj A, Pius A, Gopi S, Gopi S. Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives—a review. J Tradit Complement Med. 2017;7:205-233.\u003c\/li\u003e\r     \u003cli\u003eMantzorou M, Pavlidou E, Vasios G, Tsagalioti E, Giaginis C. Effects of curcumin consumption on human chronic diseases: a narrative review of the most recent clinical data. Phytother Res. 2018;32:957-975. \u003c\/li\u003e\r     \u003cli\u003eGupta SC, Patchva S, Aggarwal BB.  Therapeutic roles of curcumin: lessons learned from clinical trials. AAPS J.2013 Jan;15(1):195-218. \u003c\/li\u003e\r     \u003cli\u003eHe 1 Y, Yue Y, Zheng X, Zhang K, Chen S, Du Z. Curcumin, Inflammation, and Chronic Diseases: How Are They Linked? Molecules 2015, 20, 9183-9213\u003c\/li\u003e\r     \u003cli\u003eMirzaei H, Shakeri A, Rashidi B, Jalili A, Banikazemi Z, Sahebkar A.  Phytosomal curcumin: A review of pharmacokinetic, experimental and clinical studies. Biomed Pharmacother.2017 Jan;85:102-112. \u003c\/li\u003e\r     \u003cli\u003eShoba G, Joy D, Joseph T, Majeed M, Rajendran R, Srinivas PS. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med.1998 May;64(4):353-6. \u003c\/li\u003e\r     \u003cli\u003ePrasad S, Tyagi AM, Aggarwal BB. Recent Developments in Delivery, Bioavailability, Absorption and Metabolism of Curcumin: the Golden Pigment from Golden Spice Cancer Res Treat 2014 Jan; 46(1): 2–18. \u003c\/li\u003e\r     \u003cli\u003eDaily JW, Yang M, Park S.  Efficacy of Turmeric Extracts and Curcumin for Alleviating the Symptoms of Joint Arthritis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. J Med Food 19 (8) 2016, 717–729\u003c\/li\u003e\r     \u003cli\u003eDi pierro F, Zacconi P,  Bertuccioli A, Togni S. Eggenhoffner R, Giacomelli L, Scaltrini S.  A naturally-inspired, curcumin-based lecithin formulation (Meriva® formulated as the finished product Algocur®) alleviates the osteo-muscular pain conditions in rugby players. Eur Rev Med Pharmacol Sci.2017 Nov;21(21):4935-4940.\u003c\/li\u003e\r     \u003cli\u003eBelcaro G, Cesarone MR, Dugall M, Pellegrini L, Ledda A, et al. Efficacy and safety of Meriva®, a curcumin-phosphatidylcholine complex, during extended administration in osteoarthritis patients.  Altern Med Rev.2010 Dec;15(4):337-44.\u003c\/li\u003e\r     \u003cli\u003eBelcaro G, Dugall M, Luzzi R, Ledda, A, Pellegrini L, et al.  Meriva®+Glucosamine versus Condroitin+ Glucosamine in patients with knee osteoarthritis: an observational study.  Eur Rev Med Pharmacol Sci.2014;18(24):3959-63\u003c\/li\u003e\r     \u003cli\u003eEke-Okoro UJ, Raffa RB, Pergolizzi JV, Breve F, Taylor R.  Curcumin in turmeric: Basic and clinical evidence for a potential role in analgesia.  J Clin Pharm Ther. 2018;43:460–466.\u003c\/li\u003e\r     \u003cli\u003eIram F, Khan SA, Asian HA.  Phytochemistry and potential therapeutic actions of Boswellic acids: A mini-review.  Pac J Trop Biomed 2017; 7(6): 513–523. \u003c\/li\u003e\r     \u003cli\u003eAmmon HP.  Modulation of the immune system by Boswellia serrata extracts and boswellic acids. Phytomedicine.2010 Sep;17(11):862-7. \u003c\/li\u003e\r     \u003cli\u003eAmmon HP.  Boswellic Acids and Their Role in Chronic Inflammatory Diseases. Adv Exp Med Biol.2016;928:291-327. \u003c\/li\u003e\r     \u003cli\u003eHüsch J, Bohnet J, Fricker G, Skarke C, Artaria C, et al.  Enhanced absorption of boswellic acids by a lecithin delivery form (Phytosome®) of Boswellia extract.  Fitoterapia 84 (2013) 89–98. \u003c\/li\u003e\r     \u003cli\u003eDu Z, Liu Z, Ning Z, Liu Y, Song Z, Wang C, Lu A.  Prospects of Boswellic Acids as Potential Pharmaceutics. Planta Med.2015 Mar;81(4):259-71. \u003c\/li\u003e\r     \u003cli\u003eSengupta K, Krishnaraju AV, Satish AR, Mishra S, Trimurtulu G, et al.  A double blind, randomized, placebo controlled study of the efficacy and safety of 5-Loxin® for treatment of osteoarthritis of the knee.  Arthritis Res Ther.2008;10(4):R85.\u003c\/li\u003e\r     \u003cli\u003eSengupta K, Krishnaraju AV, Vishal AA, Mishra A, Trimurtulu G, et al. Comparative Efficacy and Tolerability of 5-Loxin® and Aflapin® Against Osteoarthritis of the Knee: A Double Blind, Randomized, Placebo Controlled Clinical Study.  Int J Med Sci.2010 Nov 1;7(6):366-77.\u003c\/li\u003e\r     \u003cli\u003eVishal AA, Mishra A, Raychaudhuri SP.  A Double Blind, Randomized, Placebo Controlled ClinicalStudyEvaluates theEarlyEfficacy of Aflapin® in Subjects with Osteoarthritis of Knee. Int J Med Sci.2011;8(7):615-22.\u003c\/li\u003e\r     \u003cli\u003eN.Kimmatkar, V.Thawani, L.Hingorani, R.Khiyani. Efficacy and tolerability of Boswellia serrata extract in treatment of osteoarthritis of knee – A randomized double blind placebo controlled trial.  Phytomedicine Volume 10, Issue 1, 2003, Pages 3-7 \u003c\/li\u003e\r     \u003cli\u003eCameron M, Chrubasik S. Oral herbal therapies for treating osteoarthritis.  Cochrane Database Syst Rev.2014 May 22;(5):CD002947\u003c\/li\u003e\r     \u003cli\u003eAhmad B, Rehman MU, Amin I, Arif A, Rasool S, et al.  A Review on Pharmacological Properties of Zingerone (4-(4-Hydroxy-3-methoxyphenyl)-2-butanone).  Scientific World Journal.2015; 2015: 816364.\u003c\/li\u003e\r     \u003cli\u003eAl-Nahain A, Jahan R, Rahmatullah M.  Zingiber officinale: A Potential Plant against Rheumatoid Arthritis.  Arthritis Volume 2014, Article ID 159089\u003c\/li\u003e\r     \u003cli\u003eLakhan SE, Ford CT, Tepper D.  Zingiberaceae extracts for pain: a systematic review and meta-analysis.  Nutrition Journal (2015) 14:50 \u003c\/li\u003e\r     \u003cli\u003eFunka JL, Fryea JB, Oyarzoa JN, Chena J, Zhang H, Timmermann BN. Anti-Inflammatory Effects of the Essential Oils of Ginger (Zingiber officinale Roscoe) in Experimental Rheumatoid Arthritis.  PharmaNutrition. 2016 July ; 4(3): 123–131.\u003c\/li\u003e\r     \u003cli\u003eTerry R, Posadzki P, Watson LK, Ernst E.  The Use of Ginger (Zingiber officinale) for the Treatment of Pain: A Systematic Review of Clinical Trials.  Pain Medicine 2011; 12: 1808–1818\u003c\/li\u003e\r     \u003cli\u003eChopra A, Saluja M, Tillu G, Sarmukkaddam S, Venugopalan A, et al. Ayurvedic medicine offers a good alternative to glucosamine and celecoxib in the treatment of symptomatic knee osteoarthritis: a randomized, double-blind, controlled equivalence drug trial. Rheumatology (Oxford).2013 Aug;52(8):1408-17. \u003c\/li\u003e\r     \u003cli\u003eBartels EM, Folmer VN, Bliddal H, Altman RD, Juhl C.  Efficacy and safety of ginger in osteoarthritis patients: a meta-analysis of randomized placebo-controlled trials.  Osteoarthritis and Cartilage 23 (2015) 13e21\u003c\/li\u003e\r     \u003cli\u003eMaurer HR.  Bromelain: biochemistry, pharmacology and medical use. Cell Mol Life Sci.2001 Aug;58(9):1234-45. \u003c\/li\u003e\r     \u003cli\u003eRathnavelu V, Alitheen NB, Sohila S, Samikannu KanagesanS, Ramesh R.  Potential role of bromelain in clinical and therapeutic applications (Review). Biomed Rep. 2016 Sep; 5(3): 283–288.\u003c\/li\u003e\r     \u003cli\u003ePavan R, Jain S, Shraddha, Kumar A.  Properties and therapeutic application of bromelain: a review. Biotechnol Res Int.2012;2012:976203. \u003c\/li\u003e\r     \u003cli\u003eOnken JE, Greer PK, Calingaert B, Haleb LP. Bromelain treatment decreases secretion of pro-inflammatory cytokines and chemokines by colon biopsies in vitro.  Clin Immunol 2008; 126, 345-352. \u003c\/li\u003e\r     \u003cli\u003eBrien S, Lewith G, Walker A, Hicks SM, and Middleton D.  Bromelain as a treatment for osteoarthritis: a review of clinical studies.  Evid Based Complement Alternat. 2004 Dec; 1(3): 251–257.\u003c\/li\u003e\r     \u003cli\u003eKasemsuk T, Saengpetch N, Sibmooh N, Unchern S.  Improved WOMAC score following 16-week treatment with bromelain for knee osteoarthritis.  Clin Rheumatol.2016 Oct;35(10):2531-40..\u003c\/li\u003e\r     \u003cli\u003eConrozier T, Mathieu P, Bonjean M, Marc JF, Renevier JL, Balblanc JC.A complex of three natural anti-inflammatory agents provides relief of osteoarthritis pain. Altern Ther Health Med. 2014 Winter;20 Suppl 1:32-7.\u003c\/li\u003e\r     \u003cli\u003eKlein G, Kullich W, Schnitker J, Schwann H.  Efficacy and tolerance of an oral enzyme combination in painful osteoarthritis of the hip. A double-blind, randomised study comparing oral enzymes with non-steroidal anti-inflammatory drugs Clinical and Experimental Rheumatology 2006; 24: 25-30.\u003c\/li\u003e\r     \u003cli\u003eJayachandran S, Khobre P.  Efficacy of Bromelain along with Trypsin, Rutoside Trihydrate Enzymes and Diclofenac Sodium Combination Therapy for the treatment of TMJ Osteoarthritis - A Randomised Clinical Trial.  J Clin Diagn Res. 2017 Jun; 11(6): ZC09–ZC11. \u003c\/li\u003e\r     \u003cli\u003eKooti W, Daraei N.  A Review of the Antioxidant Activity of Celery (Apium graveolens L).  J Evid Based Complementary Altern Med.2017 Oct;22(4):1029-1034.\u003c\/li\u003e\r     \u003cli\u003eAl-Asmari AK, Athar T, Kadasah SG.  An Updated Phytopharmacological Review on Medicinal Plant of Arab Region: Apium graveolens Linn.  Pharmacogn Rev2017 Jan-Jun; 11(21): 13–18. \u003c\/li\u003e\r     \u003cli\u003eAhmedy OAM, El-sayed ME, Shoka AA, ElLatif HAA, Ashraf K, et al.  Study of the anticancer potential of celery seed oil against chemically induced hepatocellular carcinoma in rats: a mechanistic approach. Az. J. Pharm Sci. Vol. 53, March, 2016. \u003c\/li\u003e\r     \u003cli\u003ePowanda MC, Whitehouse MW, Rainsford KD.  Celery Seed and Related Extracts with Antiarthritic, Antiulcer, and Antimicrobial Activities. Prog Drug Res.2015;70:133-53. \u003c\/li\u003e\r     \u003cli\u003eZhou K, Zhao F, Liu Z, Zhuang Chen L, Qiu F.  Triterpenoids and flavonoids from celery (Apium graveolens).  J Nat Prod.2009 Sep;72(9):1563-7 \u003c\/li\u003e\r     \u003cli\u003eRamezani M, Sima Nasri S, Yassa N.  Antinociceptive and anti-inflammatory effects of isolated fractions from Apium graveolens seeds in mice.  Pharmaceutical Biology, 2009; 47(8): 740–743 \u003c\/li\u003e\r     \u003cli\u003eMcGregor G, Fiebich B, Wartenberg A, Brien S, George Lewith G, Tankred Wegener T. Devil’s Claw (Harpagophytum procumbens): An anti-inflammatory herb with therapeutic potential.  Phytochemistry Reviews (2005) 4: 47–53 \u003c\/li\u003e\r     \u003cli\u003eGregory PJ, Sperry M, Wilson AF.  Dietary Supplements for Osteoarthritis Am Fam Physician.2008 Jan 15;77(2):177-84.\u003c\/li\u003e\r     \u003cli\u003eJang MH, Lim S, Han SM, Park HJ, Shin I, et al. Harpagophytum procumbens suppresses lipopolysaccharide-stimulated expressions of cyclooxygenase-2 and inducible nitric oxide synthase in fibroblast cell line L929. J Pharmacol Sci.2003 Nov;93(3):367-71.\u003c\/li\u003e\r     \u003cli\u003eHaseeb A, Ansari MY, Haqqi TM.  Harpagoside suppresses IL-6 expression in primary human osteoarthritis chondrocytes.  J Orthop Res. 2017 February ; 35(2): 311–320. \u003c\/li\u003e\r     \u003cli\u003eGagnier JJ, Chrubasik S, Manheimer E.  Harpgophytum procumbens for osteoarthritis and low back pain: a systematic review. BMC Complement Altern Med.2004 Sep 15;4:13.\u003c\/li\u003e\r     \u003cli\u003eWegener T, Lüpke NP. Treatment of patients with arthrosis of hip or knee with an aqueous extract of devil’s claw (Harpagophytum procumbens DC.). Phytother Res. 2003;17(10):1165-1172.\u003c\/li\u003e\r     \u003cli\u003eShara M, Stohs SJ.  Efficacy and Safety of White Willow Bark (Salix alba) Extracts.  Phytother Res.2015 Aug;29(8):1112-6. \u003c\/li\u003e\r     \u003cli\u003eGyawali R, Bhattarai P, Dhakal S, Jha B, Kattel SS,et al. Analgesic and Anti-inflammatory Properties of Salix alba Linn and Calotropis procera (Aiton) Dryand.  International Journal of Pharmaceutical \u0026amp; Biological Archives 2013; 4(5): 873 – 877\u003c\/li\u003e\r     \u003cli\u003eKhayyal, M. T., El Ghazaly, M. A., Abdallah, D. M., Okpanyi, S. N., Kelber, O., and Weiser, D. Mechanisms involved in the anti-inflammatory effect of a standardized willow bark extract. Arzneimittelforschung 2005;55(11):677-687 \u003c\/li\u003e\r     \u003cli\u003eSchmidt B, Ludke R, Selbmann HK, Kotter I., Tschirdewahn B, Schaffner W, Heide L.  Efficacy and tolerability of a standardised willow bark extract in patients with ostearthritis: randomised, placebo controlled, double blind clinical trial. Phytotherapy Research 2001; 15: 344–350. \u003c\/li\u003e\r     \u003cli\u003eChrubasik JE, Roufogalis BD, Chrubasik S. Evidence of effectiveness of herbal antiinflammatory drugs in the treatment of painful osteoarthritis and chronic low back pain. Phytother Res 2007;21(7):675-683.\u003c\/li\u003e\r     \u003cli\u003eR, Melzer J, Felder M, for the Swiss Assalix Study Group.  Pain Relief with a Proprietary Extract of Willow Bark in Rheumatology. An Open Trial.  Schweiz. Zschr. GanzheitsMedizin 2008;20(3):156–162.\u003c\/li\u003e\r     \u003cli\u003eSingh A, Duggal S. Piperine: review of advances in pharmacology. Int J Pharm Sci Nanotech 2009;2:615e20.\u003c\/li\u003e\r     \u003cli\u003eHazra AK, Chakraborty B, Mitra A, Sur TK. A rapid HPTLC method to estimate piperine in Ayurvedic formulations containing plant ingredients of Piperaceae family. J Ayurveda Integr Med.2018 Oct 11. pii: S0975-9476(17)30214-0. \u003c\/li\u003e\r     \u003cli\u003eSrinivasan K.  Black pepper and its pungent principle-piperine: a review of diverse physiological effects. Crit Rev Food Sci Nutr.2007;47(8):735-48.\u003c\/li\u003e\r     \u003cli\u003eMeghwal M, Goswami TK.  Piper nigrum and piperine: an update. Phytother Res.2013 Aug;27(8):1121-30 \u003c\/li\u003e\r     \u003cli\u003eMhaske DB , Sreedharan S, Mahadik KR. Role of piperine as a bioavailability enhancer. Pharm Anal Acta 2018, 9:7.\u003c\/li\u003e\r     \u003cli\u003eHan HK.  The effects of black pepper on the intestinal absorption and hepatic metabolism of drugs. Expert Opin Drug Metab Toxicol.2011 Jun;7(6):721-9.    \u003c\/li\u003e\r \u003c\/ol\u003e\r \u003cp\u003e \u003c\/p\u003e","brand":"Go Healthy","offers":[{"title":"30caps","offer_id":31177923199021,"sku":"00674-30caps","price":30.0,"currency_code":"NZD","in_stock":true},{"title":"60caps","offer_id":31177923231789,"sku":"00674-60caps","price":51.74,"currency_code":"NZD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0268\/9954\/6157\/products\/1120572.jpg?v=1573461890","url":"https:\/\/nz-nutristrong.myshopify.com\/products\/go-healthy-go-turmeric-for-joints-1-a-day","provider":"NZ NutriStrong","version":"1.0","type":"link"}