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Go Healthy Go Prostate Protect For Every Men 30+ | 30 VegeCapsules

Go Healthy Go Prostate Protect For Every Men 30+ | 30 VegeCapsules

$31.26
$31.26
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Go Healthy Go Prostate Protect For Every Man 30+ 

What is Go Prostate Protect?

Go Prostate Protect is a blend of natural herbal extracts, minerals and other ingredients designed to promote men’s well-being, by supporting prostate function, sexual health and performance, and healthy urine flow.

Why use Go Prostate Protect?

Prostate health is a growing concern for men today, particularly those over the age of 40 when they may start to experience health problems related to their prostate. Go Prostate Protect is formulated to improve the overall health of the prostate gland and lower the risks associated with prostate disorders such as urination problems, lower back pain, chronic pelvic pain syndrome all of which are warning signs of Prostate Cancer. Go Prostate Protect contains Saw palmetto which when used in combination with other herbs is sometimes used to treat prostate cancer. It is also effective for treating various types of prostate infections by improving symptoms in men who have an enlarged prostate (benign prostatic hyperplasia; BPH) thus reducing urinary urgency, frequency, pain and decreasing night-time urination.

What are the Key Benefits of Go Prostate Protect?

  • Dietary supplement with a high potency formula for prostate health
  • Natural herbal ingredients
  • Supports prostate function and healthy urine flow
  • Promotes normal sexual function 
  • Once daily vegetable based capsule

What is benign prostatic hyperplasia?

Benign Prostatic Hyperplasia (BPH) is non-cancerous growth of cells of the prostate gland, a small gland that lies just above the bladder and supplies sperm with seminal fluid. Continued growth of prostate cells causes enlargement of the prostate, which restricts urine flow resulting in symptoms like urinary retention, need for frequent urination, inability to empty the bladder, and difficulty passing urine.

What is dihydrotestosterone (DHT)?

Dihydrotestosterone (DHT) is a potent metabolite of the male hormone testosterone that is converted to DHT by the action of the enzyme 5α-reductase. DHT is the androgen that is primarily responsible for development and growth of the prostate gland and is thought to be involved in the growth of prostate cells leading to BPH.

What is an antioxidant?

An antioxidant is a substance that that protects the body from damage due oxidative stress, caused by free radicles, which are oxygen molecules containing a single electron, making them highly reactive as they scavenge to find another unpaired electron.

What is an adaptogen?

An adaptogen is a plant-derived substance that helps the body manage the physiological effects of stress and adapt to the changes experienced, without unwanted or toxic side effects.

What is apoptosis?

Apoptosis is the process of programmed cell death that is essential in regulating normal cell turnover, growth and development, healing and many other normal processes. Apoptosis ensures that a cell cannot continue to divide beyond its predetermined life span and is controlled by enzymes called caspases. Too much or too little apoptosis is implicated in the pathogenesis of several diseases including neurodegenerative diseases, ischemic damage and cancer.

What are the Ingredients of Go Prostate Protect?

Go Prostate Protect blends a selection of herbal extracts, some of which have been used in traditional medicine for thousands of years to support general health and well-being.
Each capsule of Go Prostate Protect contains the following ingredients:
  • Saw Palmetto (Serenoa repens) 4,500mg (extract equivalent to dry fruit)
  • Epilobium (Epilobium parviflorum) 1,000mg (extract equivalent to dry leaf)
  • Damiana (Turnera diffusa) 320mg (extract equivalent to dry herb)
  • Pumpkin Seed 100mg (extract equivalent to dry seed)
  • Selenium 50mcg (as Selenomethionine) 
  • Zinc citrate 50mg 
  • Lycopene 5mg

Key Ingredients:

Saw Palmetto (Serenoa Repens):

Saw Palmetto extract is made from berries of Serenoa Repens commonly known as Saw Palmetto, a small palm tree found in Florida and the South Eastern states of the USA. Saw palmetto was used in traditional medicine by native Americans for urinogenital health problems. The extract is rich in fatty acids and phytosterols and in some studies has been shown to have anti-androgen activity, meaning that it inhibits the conversion of the male hormone testosterone to dihydrotestosterone (DHT) by the enzyme 5α-reductase1. Preclinical studies have also demonstrated that Saw Palmetto extract has anti-inflammatory and anti-proliferative activity, both of which may contribute to improvements seen in symptoms of BHP. Several studies have looked at the efficacy of Saw Palmetto in controlling lower urinary tract symptoms of BPH and although there are some inconsistencies in outcomes of these studies, overall there appears to be some benefit for treating BPH with Saw Palmetto extract2, 3. Selenium added to saw palmetto extract may enhance the beneficial effects of saw palmetto4. The combination of saw palmetto with selenium and lycopene, both phytotherapeutic agents that have prostate health benefits (see below), was found to limit prostate growth in men with BPH by promoting apoptosis, to decrease cell proliferation and slow down progression of BHP5.

Epilobium (Epilobium parviflorum):

Epilobium parviflorum, also known as willowherb, is a perennial plant belonging to the Onagraceae family. Extract of Epilobium has been used in traditional medicine for its many medicinal properties including anti-inflammatory, antioxidant, antitumor, antimicrobial, analgesic, and antiandrogenic6. Epilobium is used to treat disorders of the prostate gland including BPH and prostate cancer, and in vitro studies have demonstrated that its efficacy many be due to antioxidant and antiinflammatory properties7, 8. The effect of Epilobium extract on hormone dependent cancer cells indicated that Epilobium increased apoptosis, which is reduced in cancer cells and that this effect may be due to oenothein B, one of the major pharmacologically active compounds in Epilobium extract9. In animal models Epilobium extract rich in oenothein B, resulted in reduced proliferation of prostate cells, which was partly due to antiandrogenic activity; also reduced occurrence of prostate cancer10. In vitro studies with human prostate cells demonstrated the anti-proliferative effect of Epilobium extract and its inhibition of 5α-reductase,11 supporting its use in treating BPH12.

Damiana (Turnera diffusa/aphrodisiaca):

Damiana is a shrub that grows in hot humid climates and is native to central America. As a traditional herb Damiana was used as a tonic to help with sexual problems and as an aphrodisiac, since it was thought to mimic the actions of testosterone. It was also used as a relaxant and anxiolytic, to relieve stress and anxiety. Animal studies have demonstrated a stimulating effect of Damiana on sexual behaviour and this is thought to be due to apigenin, the major pharmacologically active component13, 14.

Zinc citrate:

Zinc is a trace element found in meat, vegetable and seafoods and is essential for many aspects of human health, such as a healthy immune system, digestive system, skin structure, central nervous system and reproductive system. Zinc is needed for the functioning of the antioxidant enzyme superoxide dismutase, that protects the body against oxidative damage, and is found in high concentration in seminal plasma that nourishes sperm15. Zinc is essential for testosterone synthesis and a deficiency can cause erectile dysfunction16. The prostate gland contains high levels of zinc where it accumulates and is essential for normal function of the prostate and the quality of sperm. Reduced zinc levels have been associated with the pathogenesis of BPH and prostate cancer17, 18, 19.

Pumpkin Seed:

The pumpkin belongs to the family Cucurbitaceae, which is one of the earliest plants cultivated for their edible fruits. Pumpkin seeds have been used in traditional medicine for centuries as a remedy for kidney, bladder and prostate disorders and in contemporary herbal medicine, are used to relieve lower urinary tract symptoms of BPH. Pumpkin seeds are rich in polyunsaturated fatty acids like linoleic acid and phytosterols, which are thought to contribute to their medicinal properties. Pumpkin seeds are also rich in essential minerals like potassium, iron and zinc20, 21. Animal studies have shown that pumpkin seed oil inhibits testosterone induced proliferation of prostate cells22, 23, and in vitro studies have shown inhibition of prostate cell growth by pumpkin seed extract. Outcomes of several clinical studies have indicated that pumpkin seed oil reduces lower urinary tract symptoms of BPH20, 21, 24 , as well as a combination of pumpkin seed and saw palmetto24. The mechanism of action for the efficacy of pumpkin seed in treating BHP is thought to be due to its anti-inflammatory and antiandrogenic (inhibition of 5α-reductase) properties20, 21, 24, 25.

Lycopene:

Lycopene is a naturally occurring red pigment belonging to the carotenoid family of pigment ranging in colour from yellow of squash, orange of pumpkins, to red of tomatoes. Lycopene is found in tomatoes and other fruits and vegetables such as carrots, watermelon, papaya, and guava and has many health benefits, due to its potent antioxidant and anti-inflammatory properties26. The absorption and bioavailability of lycopene, the major pharmacologically active component of tomatoes, is increased by olive oil. The Mediterranean diet, which is rich in tomatoes and olive oil, and low in saturated fats is known for health benefits including reducing risk of cancer and cardiovascular disease26, 27. The intake of lycopene in the diet is thought to be associated with reduced risk of prostate cancer and BHP26, 27. In vitro and animal studies have indicated that lycopene acts directly on prostate cells to reduce oxidative stress, inhibit proliferation, induce apoptosis, and reduce the ability of prostate cancer cells to become metastatic (spread)28, 29. Several clinical studies have indicated that lycopene supplementation may be beneficial for treatment of prostate cancer and BHP29, 30.

Selenium:

Selenium is a mineral that is found in the soil and in foods like Brazil nuts, cereal grains and legumes. It is an essential trace element, needed in small amounts for the functioning of several enzymes including the antioxidant enzyme glutathione peroxidase, that protects the body against oxidative damage and is important for normal sperm15. Selenium also plays an important role in cardiovascular health, maintaining a healthy immune system31, and is thought to boost testosterone and support male fertility by promoting healthy sperm and semen quality15, 32.

What are the Contraindications/Interactions of Go Prostate Protect?

You should consult your doctor if you have any concerns about taking Go Prostate Protect and discuss any prescription medication you are taking, before you begin taking Go Prostate Protect. Always check the ingredients for known allergies and to ensure you do not have any allergies or sensitivities to these ingredients. Stop using if you do develop any irritation or allergy while taking Go Prostate Protect.

Caution:

You should discuss any prostate symptoms with your doctor. If you have BHP and symptoms become worse, or you find blood in the urine, seek medical advice.

Do not use:

You should not use Go Prostate Protect without discussion with your doctor if you are taking other anti-androgens like finasteride.

Side effects:

Side effects of saw palmetto in Go Prostate Protect can include gastrointestinal upset (stomach pain, nausea, vomiting, constipation or diarrhoea), low libido, breast tenderness.

What are the Dosage Recommendations for Go Prostate Protect?

Adults:

Take 1 VegeCap daily, with or without food at any time of the day but at the same time each day.

For optimal results:

Use this product long term or as recommended by your medical professional.
Take as directed and always read the label

Product Size:

30 VegeCapsules

References

The following references provide scientific support for the use of this product:
  1. Penugonda K, Lindshield BL. Fatty acid and phytosterol content of commercial saw palmetto supplements. Nutrients 2013 Sep 13;5(9):3617-33.
  2. Tacklind J, Macdonald R, Rutks I, Stanke JU, Wilt TJ. Serenoa repens for benign prostatic hyperplasia. Cochrane Database Syst Rev 2012 Dec 12;12:
  3. Minutoli L,Bitto A, Squadrito F, Marini H, Irrera N, Morgia G, Passantino A, Altavilla D. Serenoa Repens, lycopene and selenium: a triple therapeutic approach to manage benign prostatic hyperplasia. Curr Med Chem 2013;20(10):1306-12.
  4. Multescu R, Geavlete B. Serenoa repens extract in the treatment of benign prostatic hyperplasia Petrisor Geavlete. Ther Adv Urol (2011) 3(4) 193198.
  5. Morgia G, Micali A, Rinaldi M, Irrera N, Marini H, et al. Survivin and NAIP in Human Benign Prostatic Hyperplasia: Protective Role of the Association of Serenoa repens, Lycopene and Selenium from the Randomized Clinical Study. Int. J. Mol. Sci. 2017, 18, 680;
  6. Vitalone A, Allkanjari O. Epilobium spp: Pharmacology and Phytochemistry. Phytother Res.2018 Jul;32(7):1229-1240. 
  7. Hevesi BT, Houghton PJ, Habtemariam S, Kéry A. Antioxidant and antiinflammatory effect of Epilobium parviflorum Schreb. Phytother Res 2009 May;23(5):719-24. 
  8. Steenkamp V, Gouws MC, Gulumian M, Elgorashi E, Evan Staden J. Studies on antibacterial, anti-inflammatory and antioxidant activity of herbal remedies used in the treatment of benign prostatic hyperplasia and prostatitis. J Ethnopharmacol.2006 Jan 3;103(1):71-5. Epub 2005 Aug 24. 
  9. Stolarczyk M, Naruszewicz M, Kiss AK. Extracts from Epilobium sp. herbs induce apoptosis in human hormone-dependent prostate cancer cells by activating the mitochondrial pathway. J Pharm Pharmacol.2013 Jul;65(7):1044-54. 
  10. Piwowarski JP, Bobrowska-Korczak B, Stanisławska I, Bielecki W, Wrzesien R, et al. Evaluation of the Effect of Epilobium angustifolium Aqueous Extract on LNCaP Cell Proliferation in In Vitro and In Vivo Models. Planta Med.2017 Oct;83(14-15):1159-1168.
  11. Lesuisse D, Berjonneau J, Ciot C, Devaux P, Doucet B. Determination of oenothein B as the active 5-alpha-reductase-inhibiting principle of the folk medicine Epilobium parviflorum. J Nat Prod.1996 May;59(5):490-2. 
  12. Vitalone A, McColl J, Thome D, Costa L.G, Tita B. Characterization of the Effect of Epilobium Extracts on Human Cell Proliferation. Pharmacology 2003;69:79–87
  13. Kumar S, Madaan R, Sharma A. Estimation of Apigenin, an Anxiolytic Constituent, in Turnera aphrodisiaca. Indian J Pharm Sci 2008 Nov;70(6):847-51. 
  14. Szewczyk K, Zidorn C. Ethnobotany, phytochemistry, and bioactivity of the genus Turnera (Passifloraceae) with a focus on damiana--Turnera diffusa. J Ethnopharmacol.2014 Mar 28;152(3):424-43. 
  15. Nenkova G, Petrov L, Alexandrova A. Role of Trace Elements for Oxidative Status and Quality of Human Sperm. Balkan Med J 2017 Aug 4;34(4):343-348. 
  16. Prasad AS, Mantzoros CS, Beck FW, Hess JW, Brewer GJ. Zinc status and serum testosterone levels of healthy adults. Nutrition 1996 May;12(5):344-8. 
  17. Christudoss P, Selvakumar R, Fleming JJ, Gopalakrishnan G. Zinc status of patients with benign prostatic hyperplasia and prostate carcinoma. Indian J Urol2011 Jan-Mar; 27(1): 14–18. 
  18. Franklin RB, Milon B, Feng P, Costello LC. Zinc and Zinc Transporters in Normal Prostate Function and the Pathogenesis of Prostate Cancer. 
  19. Costello LC, Franklin RB. The Intermediary Metabolism of the Prostate: A Key to Understanding the Pathogenesis and Progression of Prostate Malignancy. Oncology. 2000 November ; 59(4): 269–282. 
  20. Shirvan MK, Mahboob MRD, Masuminia M, Mohammadi S. Pumpkin seed oil (Prostafit) or Prazosin? Which one is better in the treatment of symptomatic benign prostatic hyperplasia. J Pak Med Assoc Vol. 64, No. 6, June 2014 
  21. Vahlensieck W, Theurer C, Pfitzer E, Patz B, Banik N, Engelmann U. Effects of Pumpkin Seed in Men with Lower Urinary Tract Symptoms due to Benign Prostatic Hyperplasia in the One-Year, Randomized, Placebo-Controlled GRANU Study. Urol Int 2015;94:286–295. 
  22. Tsai YS, Tong YC, Cheng J, TLee CH, Yang FS, Lee HY. Pumpkin seed oil and phytosterol-F can block testosterone/prazosin-induced prostate growth in rats. Urol Int.2006;77(3):269-74. 
  23. Gossell-Williams M, Davis A, O'Connor N. Inhibition of testosterone-induced hyperplasia of the prostate of sprague-dawley rats by pumpkin seed oil. J Med Food.2006 Summer;9(2):284-6. 
  24. Hong H, Kim C-S, Sungho Maeng S. Effects of pumpkin seed oil and saw palmetto oil in Korean men with symptomatic benign prostatic hyperplasia Nutrition Research and Practice (2009), 3(4), 323-327
  25. Medjakovic S, Hobiger S, Ardjomand-Woelkart K, Bucar F, Jungbauer A. Pumpkin seed extract: Cell growth inhibition of hyperplastic and cancer cells, independent of steroid hormone receptors Fitoterapia 110 (2016) 150–156
  26. Story EN, Kopec RE, Schwartz SJ, Harris GK. An Update on the Health Effects of Tomato Lycopene.Annu Rev Food Sci Technol. 2010 ; 1:
  27. Capurso C, Vendemiale G. The Mediterranean Diet Reduces the Risk and Mortality of the Prostate Cancer: A Narrative Review. frontiers in nutrition 2017 volume 4 article 38
  28. Holzapfel NP, Holzapfel BM, Champ S, Feldthusen J, Clements J, Werner Hutmacher DW. The Potential Role of Lycopene for the Prevention and Therapy of Prostate Cancer: From Molecular Mechanisms to Clinical Evidence. Int. J. Mol. Sci. 2013, 14, 14620-14646. 
  29. Jiang L-N, Liu Y-B, Li B-H. Asian Lycopene exerts anti inflammatory effect to inhibit prostate cancer progression. Journal of Andrology (2018) 20, 1–6. 
  30. . Ilic D, Missob M. Lycopene for the prevention and treatment of benign prostatic hyperplasia and prostate cancer: A systematic review. Maturitas 72 (2012) 269– 276. 
  31. Zhang C, Deng Y, Lei Y, Zhao J, Wei W, Li Y. Effects of selenium on myocardial apoptosis by modifying the activity of mitochondrial STAT3 and regulating potassium channel expression. Exp Ther Med 2017 Sep;14(3):2201-2205. 
  32. Safarinejad MR, Safarinejad S. Efficacy of selenium and/or N-acetyl-cysteine for improving semen parameters in infertile men: a double-blind, placebo controlled, randomized study. J Urol. 2009 Feb;181(2):741-51.