Go Healthy Go Probiotic 75 Billion 1-A-Day

Go Healthy Go Probiotic 75 Billion 1-A-Day

What is Go Probiotic 75 Billion 1-A-Day?

Go Probiotic 75 Billion is a high strength blend of multi-strained probiotic bacteria, which are live bacteria that provide health benefits. This probiotic blend is designed to restore and maintain a healthy balanced gut flora, which is essential to promote digestive health, protect against damage to the gastrointestinal system, maintain a strong immune system and promote general health and wellbeing.

Why use Go Probiotic 75 Billion 1-A-Day?

Gut health is essential for overall health and wellness and this includes a balanced gut flora or microbiota, which is the complete collection of microorganisms that inhabit the gut The gut microbiota should contain a balance between “good” bacteria, that provide many health benefits, and potentially pathogenic bacteria that cause harm to the gastrointestinal system and can trigger the gut immune system resulting in allergic and inflammatory reactions. This balance can be disrupted by several factors including diet, lifestyle and medications, particularly non-steroidal anti-inflammatory drugs (NSAIDs) and antibiotics. Go Probiotic 75 Billion contains a high strength blend of multi-strained probiotic bacteria, designed to restore and maintain a healthy balanced gut flora, which is essential to promote digestive health, protect against damage to the gastrointestinal system, maintain a strong immune system and promote general health and wellbeing.

What are the Key Benefits of Go Probiotic 75 Billion

• Clinically researched blend of multi-strain probiotic bacteria 
• Promotes a balanced gut microflora
• Supports the gut immune system
• Support the gut barrier function
• Suitable for taking with and after antibiotics to protect microflora balance
• Delayed release technology to protect probiotics from the acidic stomach environment and ensure their survival
• Convenient once a day dosing
• Suitable for long-term use
• Capsules are vegan and gluten and dairy free 
• Suitable for vegetarians and dairy or gluten intolerances

What are probiotics?

Probiotics are defined as “live microorganisms which when administered in adequate amounts confer a health benefit on the host”^1. To put it more simply, we coexist with millions of live bacteria and other microorganisms in and on our body, the majority living in our gut, and these microorganisms are collectively known as the microbiota. Probiotic refer to bacteria that live in the intestines and play an active health-promoting role^{2, 3, 4.} The most well-known probiotics are Lactobacillus and Bifidobacteria species and they begin to develop in the gut of a new-born soon after birth^5. The balance between probiotic bacteria and potentially harmful bacteria, which together make up the microbiota of our gut, can be affected by several factors. These include diet (high fat and sugar), excess alcohol, ageing, some medication (particularly antibiotics and NSAIDs), illness, stress, infection (enteric pathogens causing gastroenteritis), and lifestyle factors like smoking and lack of exercise. An imbalance in the microbiota can cause health problems, due to digestive issues like lactose intolerance, or an impaired immune system predisposing to infection or to food allergies; while other are more serious such as Inflammatory Bowel Disease (IBD) and Irritable Bowel Syndrome (IBS^{)6, 7, 8.}

Health benefits of probiotics include:

• supporting the digestion of our food and absorption of vital nutrients
• protecting the gastric mucosa and maintaining the intestinal barrier function 
• protecting against invasion with pathogenic microorganisms
• reducing inflammation due to their anti-inflammatory properties
• boosting the immune system, due to their immunomodulatory properties

Probiotics and the gut immune system

The gut wall contains 75-80% of our entire immune system and a finely tuned balance is maintained between the intestinal immune system and the gut microbiota, which have evolved together to support health and wellbeing. The intestinal immune system protects against invasion with pathogenic microorganisms that cause disease, while at the same the immune cells maintain tolerance to many innocuous microorganisms and food substances in the gut. An imbalance in the microbiota (dysbiosis) can impact significantly on health and disease outcomes. The immune system can be triggered to initiate an inflammatory or allergic response, which can result in diseases of the gut, such as Inflammatory Bowel Disease (IBD), Irritable Bowel Syndrome (IBS), or even predispose to systemic diseases like obesity and diabetes^{9, 10, 11, 12.}

How do probiotics protect and restore gut health?

Probiotics help protect gut health and restore balance to a disturbed gut flora by several mechanisms. Probiotic bacteria compete with pathogenic bacteria for binding sites on the gut surface, which are essential for pathogenic bacteria to be able to colonise in the gut. Probiotics also produce acids that increase the acidic environment of the gut, in which many pathogens, such as enterohemorrhagic Escherichia coli, cannot survive; as well as producing bactericidal metabolites that kill some pathogenic bacteria, such as Salmonella, Staphylococcus, Clostridium and Listeria species. Immune system modulation by probiotics activates cells of the gut immune system to fight bacteria. The intestinal barrier function is critical for gut health, preventing inflammation and invasion with pathogenic microorganisms. Probiotics protect the gut mucosa by stimulating mucus production, which also helps repair damage, restoring tight junctions between mucosal cells, and reducing production of inflammatory mediators^{13, 14, 15.} Probiotics can help reduce lactose intolerance by digesting lactose, which can be triggered by an imbalance in gut microbiota12. The final stage of digestion occurs in the colon, where non-digestible carbohydrates are fermented by the microbiota into various metabolites, mainly the short-chain fatty acids (SCFA) acetate, propionate and butyrate; also lactate, which is substrate for SCFA producing bacteria^{16, 17. I}ntroduction of a mixture of probiotic species was shown to restore balance to the microbiota by ensuring colonisation of SCFA producing bacteria, particularly butyrate, which has immunomodulating and anti-inflammatory properties^18.

Probiotics and inflammatory bowel disease

Disturbances to a balanced gastrointestinal microbiota are involved in the pathogenesis of inflammatory bowel disease (IBD) like ulcerative colitis and Chron’s disease and studies indicate that an immune response to the intestinal microbiota may be responsible, along with damage to the intestinal barrier function of the gastric mucosa. Probiotics have been found effective in treating IBD by preventing relapse and inducing remission in active IBD due to modulation of immune cells and by suppression of inflammatory cytokines and induction of anti-inflammatory cytokines ^{6, 19, 20.}

Probiotics and antibiotics

Antibiotics can cause a major alteration in the gut microbiota, by reducing the numbers of probiotic bacteria, leaving harmful microorganisms like Clostridium difficile to take over. This results in antibiotic associated diarrhoea (AAD), which has become a major complication of antibiotic use, and has also increased risk of antibiotic resistance within the individual microbiota. Several studies have demonstrated that probiotics are a safe and effective treatment to help restore balance to gut flora when taking antibiotics^{3, 21, 22;} and may be used for prophylaxis in preventing AAD for high risk patients in both hospital and outpatient settings, particularly for those who have previously had serious episodes of AAD^23,24,25,26.

Probiotics and NSAID-induced enteropathy

Non-steroidal anti-inflammatory drugs (NSAIDs) are commonly used for pain and inflammation but in many cases can cause damage to the gastric mucosa resulting in a range of gastrointestinal symptoms known as NSAID-induced enteropathy. These include abdominal pain, abdominal distension, nausea, indigestion, constipation, and more seriously intestinal bleeding and ulceration. It is thought that NSAID-induced enteropathy is caused by dysbiosis or an imbalance between in the gut microbiota^27. Animal and clinical studies have demonstrated that probiotics are effective in protecting against NSAID-induced enteropathy^{28, 29.}

What is an immunomodulator?

The immune system is the body’s natural defence against invasion by environmental pathogens, like bacteria, viruses and parasites, and is a complex process that involves many cell types that produce an array of chemical mediators like cytokines and interferon; also antibodies. The various components of the immune system work together with the aim of recognising foreign invaders from self and destroying the invader. An immunomodulator is a substance (chemical or herbal) that affects the way the immune system works either by stimulating it (immunostimulant) or suppressing it (Immunosuppressant).

What is CFU?

A colony forming unit (CFU) is an estimate of the number of viable bacterial cells that are alive and can multiply to form colonies under controlled conditions. The number of CFUs is used to quantify how many living bacteria exist in a biological sample.

What are the Ingredients of Go Probiotic 75 Billion?

Each capsule of Go Probiotic 75 Billion contains the following probiotic bacteria.

HOWARU Restore providing 40 billion CFU (Colony Forming Units) comprising:

• Lactobacillus acidophillus ATCC 10 billion cells CFU,
• Lactobacillus paracasei 10 billion cells CFU
• Bifidobacterium lactis (strain Bi-07) 10 billion cells CFU
• Bifidobacterium lactis (strain Bl-04) 10 billion cells CFU

Multi-strain probiotics providing 35 billion CFU (Colony Forming Units) comprising:

• Lactobacillus plantarum 5.5 billion cells CFU
• Lactobacillus salivarius ssp. 11 billion cells CFU
• Lactobacillus casei 5.625 billion cells CFU
• Bifidobacterium breve 1.25 billion cells CFU
• Lactobacillus acidophilus 10 billion cells CFU
• Lactobacillus rhamnosus (HN) 0.250 billion cells CFU
• Lactobacillus bulgaricus 0.125 billion cells CFU
• Bifidobacterium longu 1.25 billion cells CFU

HOWARU Restore

HOWARU Restore in Go Probiotic 75 Billion is a mixture of four strains of probiotics that have been tested for their safety and efficacy in providing health benefits, when used as probiotic supplements. These are Lactobacillus acidophilus NCFM (ATCC SD5221), Lactobacillus paracasei Lpc-37 (ATCC SD5275), Bifidobacterium animalis subsp. lactis Bl-04 (ATCC SD5219) and B. animalis subsp. lactis Bi-07 (ATCC SD5220), blended in a 1:1:1:1 ratio^30. Lactobacillus acidophillus, Lactobacillus paracasei and Bifidobacterium lactis (strains BI-07 and Bl-04) are non-spore forming, species of probiotic bacteria that produce lactic acid but through different metabolic pathways. Lactobacilli are more prevalent in the upper intestines, whereas bifidobacterial are found mainly in the colon. Bifidobacterium lactis is found in faeces of infants indicating that it is present early in life and therefore, makes up an important part of the early microbiota. These strains have been widely used in probiotic supplements and are considered safe for consumption^30. A clinical study demonstrated that use of HOWARU Restore given to hospital patients receiving antibiotic treatment, reduced the incidence of antibiotic associated diarrhoea (AAD) and Clostridium difficile associated diarrhea (CDAD); also the severity of gastrointestinal symptoms^31.

Multi-strain probiotics

Go Probiotic 75 Billion also contains a high strength muliti-strain blend of probiotic bacteria that provides additional probiotic support along with the HOWARU Restore mixture. Many individual probiotic bacteria, when studied as single strain probiotics have beneficial effects in various physiological processes, however, different species and even different strains of the same species can have different effects on the same condition or work through a different mechanism32. Using an in vitro model of the human colon, multi strain versus single strain probiotics were compared in terms of survival and growth, and it was demonstrated that multi-strain probiotics do not have antagonistic effects but can coexist in gut^33. Several studies have indicated that multi strain probiotics confer greater health benefits than single strain probiotics due to additive effects or synergy between strains^34. Using various combinations of multi-strain probiotics, health benefits demonstrated include strengthening the gut barrier function, improving symptoms of food intolerance, reduced antibiotic associated diarrhoea, relieved symptoms of IBS^35. Multi-species probiotic mixtures significantly increased the faecal concentration of most probiotic strains and improved diarrhoea symptom scores in IBS patients^36. Lactobacillus plantarum and Bifidobacterium breve have been shown to have effects on behaviour and cognitive function in animal models^37. In a review of clinical studies using single strain and multi-strain probiotic therapy for Irritable bowel syndrome (IBS), the conclusion was reached that the beneficial effects of reducing symptoms was species specific, and a multi-strain approach provided a more effective treatment due to restoring the microbiota balance^38.   

What are the Contraindications/Interactions of Go Probiotic 75 Billion?

You should always check the ingredients for known allergies and to ensure you do not have any allergies or sensitivities to these ingredients. Stop using if you develop any irritation or allergy while taking Go Probiotic 75 Billion. Always read the label and use as directed or seek advice from your healthcare professional.

Caution

Go Probiotic 75 Billion should be used with caution if immunocompromised.

Side effects

Probiotics are considered safe and any side effects are usually minimal but can include gas and bloating.

What are the Directions for using Go Probiotic 75 Billion?

Take one VegeCapsule of Go Probiotic 75 Billion once daily with food.

Product Sizes

30 & 60 VegeCapsules

References

The following references provide scientific support for the use of this product:

1. FAO/WHO. Guidelines for the evaluation of probiotics in food. Report of a Joint FAO/WHO Working Group on Drafting Guidelines for the Evaluation of Probiotics in Food; Ontario, Canada. April 30 and May 1, 2002.
2. Behnsen J, Deriu E, Sassone-Corsi M, Raffatellu M. Probiotics: properties, examples, and specific applications. Cold Spring Harb Perspect Med. 2013;3:a010074.
3. Clemente JC, Ursell LK, Parfrey LW, Knight R. The Impact of the Gut Microbiota on Human Health: An Integrative View. Cell 2012, 148 issue 6, 1258-70
4. O’Hara AM, Shanahan F. The gut flora as a forgotten organ. EMBO Reports 2006; 7(7) 688-693.
5. Servin AL. Antagonistic activities of lactobacilli and bifidobacteria against microbial pathogens. FEMS Microbiology Reviews 28 (2004) 405–440
6. Orel R, Kamhi Trop T. Intestinal microbiota, probiotics and prebiotics in inflammatory bowel disease. World J Gastroenterol. 2014 Sep 7;20(33):11505-24
7. Cresci GA, Bawden E. Gut Microbiome: What We Do and Don't Know. Nutr Clin Pract 2015 Dec;30(6):734-46. 
8. Hungin APS, C. Mulligan C, Pot B, . Whorwell P, Agreus L, Fracasso P, et al. Systematic review: probiotics in the management of lower gastrointestinal symptoms in clinical practice – an evidence based international guide. Aliment Pharmacol Ther 2013 Oct; 38(8): 864–886.
9. Cader MZ, Kaser A. Recent advances in inflammatory bowel disease: mucosal immune cells in intestinal inflammation. Gut 2013 Nov;62(11):1653-64. 
10. Lei YM, Nair L, Alegre ML. The interplay between the intestinal microbiota and the immune system. Clin Res Hepatol Gastroenterol 2015 Feb;39(1):9-19. 
11. Bischoff C. 'Gut health': a new objective in medicine? BMC Medicine2011; 9:24
12. Oak SJ, Jha R. The effects of probiotics in lactose intolerance: A systematic review. Crit Rev Food Sci Nutr 2018 Feb 9:1-9. How do probiotics work
13. Mathipa MG, Thantsha MS. Probiotic engineering: towards development of robust probiotic strains with enhanced functional properties and for targeted control of enteric pathogens. Gut Pathog (2017) 9:28
14. Vanderpool C, Yan F, Polk DB. Mechanisms of probiotic action: implications for therapeutic applications in inflammatory bowel diseases. Inflamm Bowel Dis. 2008;14:1585–1596.
15. Doron S, Gorbach SL. Probiotics: their role in the treatment and prevention of disease. Expert Rev Anti Infect Ther.2006 Apr;4(2):261-75. 
16. den Besten G., van Eunen K., Groen A. K., Venema K., Reijngoud D.-J., Bakker B. M. (2013). The role of short-chain fatty acids in the interplay between diet, gut microbiota, and host energy metabolism. J. Lipid Res. 54 2325–2340. 10. 
17. Rivière A, Selak M, Lantin D, Leroy F, De Vuyst L. Bifidobacteria and Butyrate-Producing Colon Bacteria: Importance and Strategies for Their Stimulatioan in the Human Gut. Front Microbiol 2016; 7: 979.
18. Moens F, Van den Abbeele P, Basit AW, Dodoo C, Chatterjee R, Smithd B, Gaisford S. A four-strain probiotic exerts positive immunomodulatory effects by enhancing colonic butyrate production in vitro. Int J of Pharm 2018; 555, 1–10. 
19. Derwa Y, Gracie DJ, Hamlin PJ, Ford AC. Systematic review with meta-analysis: the efficacy of probiotics in inflammatory bowel disease. Aliment Pharmacol Ther 2017 Aug;46(4):389-400. 
20. Ganji-Arjenaki M, Rafieian-Kopaei M. Probiotics are a good choice in remission of inflammatory bowel diseases: A meta analysis and systematic review. J Cell Physiol 2018 
21. Cai J, Zhao C, Du Y, Zhang Y, Zhao M, Zhao Q. Comparative efficacy and tolerability of probiotics for antibiotic-associated diarrhea: Systematic review with network meta-analysis. United European Gastroenterol J 2018 Mar;6(2):169-180. 
22. Goldenberg JZ, Yap C, Lytvyn L, Lo CKF, Beardsley J, Mertz D, Johnston BC. Probiotics for the prevention of Clostridium difficile-associated diarrhea in adults and children. Cochrane Database Syst Rev. 2017 Dec 19;12:CD006095. 
23. Issa I, Moucari R. Probiotics for antibiotic-associated diarrhea: Do we have a verdict? World J Gastroenterol.2014 Dec 21;20(47):17788-95.
24. Blaabjerg S, Artzi DM, Rune Aabenhus R. Probiotics for the Prevention of Antibiotic-Associated Diarrhea in Outpatients—A Systematic Review and Meta-Analysis. Antibiotics 2017, 6, 21;
25. Hempel S, Newberry SJ, Maher AR, Wang Z, Miles JN, et al. Probiotics for the Prevention and Treatment of Antibiotic-Associated Diarrhea A Systematic Review and Meta-analysis. JAMA. 2012 May 9;307(18):1959-69. 
26. Johnston BC, Ma SS, Goldenberg JZ, et al. Probiotics for the prevention of Clostridium difficile-associated diarrhea: a systematic review and meta-analysis. Ann Intern Med. 2012;157:878–888. 
27. Rogers MAM, Aronoff DM. The influence of non-steroidal anti-inflammatory drugs on the gut microbiome. Clin Microbiol Infect 2016; 22: 178.e1–178.e9
28. Syer SD, Blackler RW, Martin R, de Palma G, Rossi L, et al. NSAID enteropathy and bacteria: a complicated relationship. J Gastroenterol.2015 Apr;50(4):387-93.
29. Montalto M, Gallo A, Gasbarrini A, Landolfi R. NSAID enteropathy: could probiotics prevent it? J Gastroenterol.2013 Jun;48(6):689-97. 
30. Morovica W, Roper JM, Smith AB, Mukerji P, Stahla B, Rae JC, Ouwehand AC. Safety evaluation of HOWARU® Restore (Lactobacillus acidophilus NCFM, Lactobacillus paracasei Lpc-37, Bifidobacterium animalis subsp. lactis Bl-04 and B. lactis Bi-07) for antibiotic resistance, genomic risk factors, and acute toxicity. Food and Chemical Toxicology 110 (2017) 316–324
31. Ouwehand AC, DongLian C, Weijian X, Stewart M, Ni J, Stewart T, Miller LE. Probiotics reduce symptoms of antibiotic use in a hospital setting: a randomized dose response study. Vaccine.2014 Jan 16;32(4):458-63. 
32. Gareau MG, Sherman PM, Walker WA. Probiotics and the gut microbiota in intestinal health and disease. Nat Rev Gastroenterol Hepatol. 2010 September ; 7(9): 503–514. 
33. Forssten SD, Ouwehand AC. Simulating colonic survival of probiotics in single-strain products compared to multi-strain products. Microb Ecol Health Dis.2017 Oct 17;28(1):1378061.
34. Timmerman H. M., Koning C. J. M., Mulder L., Rombouts F. M., Beynen A. C. (2004). Monostrain, multistrain and multispecies probiotics—a comparison of functionality and efficacy. Int. J. Food Microbiol 2004. 96 219–233 
35. El Hage R, Hernandez-Sanabria E, Van de Wiele T. Emerging Trends in “Smart Probiotics”: Functional Consideration for the Development of Novel Health and Industrial Applications. Front Microbiol 2017; 8: 1889.
36. Yoon H, Park YS, Lee DH, Seo J, Shin CN, Kim N. Effect of administering a multispecies probiotic mixture on the changes in fecal microbiota and symptoms of irritable bowel syndrome: a randomized, double-blind, placebo-controlled trial. J Clin Biochem Nutr2015 Sep; 57(2): 129–134. 
37. Kobayashi Y, Sugahara H, Shimada K, Mitsuyama E, Kuhara T, et al. Therapeutic potential of Bifidobacterium breve strain A1 for preventing cognitive impairment in Alzheimer’s disease. Scientific Reports volume 7, Article number: 13510 (2017). 
38. Korpela R, Niittynen L. Probiotics and irritable bowel syndrome. Microb Ecol Health Dis 2012; 23: 18573.