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Clinicians Sleep Science with Magnesium and ETAS | 30 Vegetable Capsules

Clinicians Sleep Science with Magnesium and ETAS | 30 Vegetable Capsules

$34.74
$34.74
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Clinicians Sleep Science with Magnesium and ETAS™

What is Sleep Science?

Sleep Science is a combination of natural herbal ingredients and minerals that reduce stress and help to calm and relax the body ready for sleep. Sleep Science supports a healthy sleep pattern if you suffer from insomnia or stress, or having problems sleeping due to menopausal hormonal changes. Sleep Science helps you get to sleep and stay asleep so that you have a good night’s sleep and wake refreshed and rested for the day ahead.

Why use Sleep Science?

Sleep is a time when our body restores vital processes and is important to our health and wellbeing and ultimately to our survival. Lack of quality sleep that includes the normal sleep cycle can have serious effects on our ability to function in everyday life, as well as impacting on our health and overall quality of life. Insomnia or some form of disruption to normal sleep patterns is a common problem, and can be due to many factors including stress, anxiety, a health condition, shift work and menopausal hormonal changes. Sleep Science contains a combination of natural herbal ingredients and minerals that supports natural sleep patterns, by reducing stress and promoting calm and relaxation to help you get a good night’s sleep. Sleep Science can provide effective sleep support to overcome sleep problems by helping to fall asleep and stay asleep, so that you wake refreshed and rested for the day ahead.

What are the Key Benefits of Sleep Science?

  • Provides natural sleep support when anxiety or stress is keeping you awake
  • Natural ingredients to calm and relax the body ready for sleep
  • Natural herbal ingredients that protect against the harmful effects of stress that can cause sleep problems, anxiety and depression
  • Natural herbal ingredients that supports cognitive function and promotes clear thinking
  • Gluten and dairy free
  • No added yeast, sugar or artificial colours, sweeteners, flavours or preservatives

What is sleep?

Sleep is not a time of inactivity but is when the brain carries out many restorative processes and manages the nerve pathways that allow us to function. Meanwhile the rest of our body is busy making repairs, clearing away toxins and producing hormones. Quality sleep, and enough of it, is essential to our well-being. Sleep deprivation is associated with memory loss, difficulty concentrating, reduced immune function and increased risk of diseases like cardiovascular disease, diabetes, depression and obesity.

The normal sleep cycle

The normal sleep cycle lasts about 90 minutes and is repeated 4-6 times a night. One cycle consists of the first four stages of non-rapid eye movement sleep (NREM), during which we move from very light sleep gradually into deep sleep, when it is difficult to be awakened. During NREM there is little eye activity, heartbeat and breathing slows, body temperature falls, and brainwave activity gradually become slower. This is when the body is most relaxed and when it undergoes restorative processes like renewing energy supplies, tissue repair, boosting the immune system and secreting hormones that control growth and metabolism. The next stage of sleep is known as rapid eye movement sleep (REM). During REM Sleep, although the eyes are moving, the muscles in our arms and legs are temporarily paralysed. The eyes move rapidly from side to side under the eyelids, heartrate increases, and breathing becomes fast irregular and shallow. This stage is associated with dreaming and if woken during this stage we often remember our dreams. REM is an important stage in the sleep cycle as this is the time when the brain processes and stores information, which is important for learning and memory. The sleep/wake cycle determines when it is time to sleep and when it is time to wake and is controlled by the circadian rhythm, which is the body’s internal clock that controls cyclical changes in the body like sleep, body temperature and hormone secretion over a 24-hour period. Circadian rhythm is set by external cycles of daylight and darkness and involves the secretion of the melatonin, the sleep hormone, which is produced in the pineal gland of the brain. The secretion of melatonin is triggered by darkness so that it is produced at night and regulates the natural sleep/wake cycle1.

What is insomnia?

Insomnia is any disturbance in the normal pattern sleep that leaves you unrefreshed in the morning and affects your ability to function. Insomnia is a sleep disorder that can be short term or long term and is characterised by difficulty falling asleep, staying asleep, waking in the night, waking too early and not being able to go back to sleep, or a combination of all these.

What is an anxiolytic?

An anxiolytic is a substance that can relieve anxiety, aid sleep, or have a calming effect. Anxiety is a factor is sleep disruption and if reduced this can help restore quality sleep patterns.

What is stress?

Stress is the body’s response to any perceived danger and can include environmental, social and psychological factors. Stress is regulated by the autonomic nervous system, the immune system and the endocrine system, resulting in physical responses like increased heart rate and blood pressure, and hormonal responses leading to secretion of cortisol, known as the stress hormone. Once the cause of the stress response is removed, the body returns to normal, which is called homeostasis. However, if the stress response is continually stimulated this can result in chronic stress, which contributes to many health problems including depression and sleep disorders.

What are stress proteins?

Stress proteins, also known as heat shock proteins (HSP) are produced in response to various forms of stress including physical, chemical, biological and psychological stress2. HSP protect the body from many stresses including stress caused by infection, fever, inflammation, ultraviolet radiation, starvation, lack of oxygen (hypoxia) and to exposure to toxins. HSP also reduce blood levels of cortisol, in a negative feedback mechanism through the glucocorticoid receptor, blocking the production of cortisol3.  

What are the Ingredients in Sleep Science?

Each capsule of Sleep Science contains the following active ingredients:
  • ETAS™ (proprietary extract of Asparagus officinalis) 100mg (extract equivalent to dry herb)
  • Chinese date (Zizyphus jujube) 1000mg (extract equivalent to seed)
  • Magnesium aspartate complex 500 mg (equivalent to magnesium 100 mg)
Other Ingredients
  • Magnesium stearate
  • Silica

Key Ingredients:

ETAS™ Asparagus (Asparagus officinalis):

Asparagus is a perennial herb, grown widely throughout Europe and Asia and has been used in traditional medicine for its properties as a diuretic and for its hypolipidemic (lipid lowering) and hypoglycemic (blood sugar lowering) effects. ETAS is an extract of asparagus stalks, prepared using a specific extraction procedure (enzyme treated asparagus extract), that has several beneficial properties including stress relief, sleep control, and improved memory and cognitive function4. ETAS is rich in the active component asfural, which has been shown to induce the production of HSP as well as suppress blood cortisol levels in animal studies5. In a study with healthy volunteers, ETAS induced HSP and reduced blood cortisol levels, and improved sleep efficiency, compared with a placebo group6. The effects of ETAS on stress related markers has been found to exert ant-stress effects in animal and human studies4. The effects of ETAS on stress, including biological markers and psychological stress parameters, was studied in a group of healthy volunteers. The results demonstrated improved stress control and management which included better sleep quality and performance under stress7. Animal studies indicate that ETAS may support also cognitive function by protecting nerve cells8.

Chinese date (Zizyphus jujube)

The Chinese date, also known as jujube, has been used in Chinese herbal medicine for thousands of years to treat anxiety and insomnia. In contemporary herbal medicine, dried jujube seeds are used for cardiovascular and digestive health, regulating the immune system, and for antioxidant, sedative, anxiolytic, sedative and analgesic properties. They are also used in the treatment of insomnia and forgetfulness and to calm the mind and relieve mental tension 9,10  The pharmacologically active compounds that contribute to these medicinal properties of jujube include saponins, flavones and alkaloids. Animal model studies with dried jujube seeds have demonstrated increased sleep time, including more REM sleep and this is thought to be due to interaction with serotonin receptors in the brain11. These studies also demonstrated that the saponin jujubosides, one of the major components of jujube seeds, have a hypnotic effect that involves serotonin and is influenced by circadian rhythm12. 

Magnesium aspartate complex

Magnesium is an essential mineral obtained from the diet and has been used in traditional medicine to promote calm and relaxation. Magnesium is important for many physiological processes, including maintaining normal nerve and muscle function, production of energy, control of blood pressure, normal heartbeat, and regulation of the endocrine (hormone) and immune system. Magnesium deficiency is common and is thought to be related to several health problems including high blood pressure, cardiovascular disease, and mood disorders like anxiety and depression. A review of clinical studies indicates that supplementation with magnesium is associated with reduced stress and anxiety13, and also depression14. Magnesium supplementation has also been found to improve sleep quality in a study of elderly people with insomnia and also increased blood levels of melatonin15. Animal and clinical studies have suggested a role for magnesium in circadian rhythm and sleep regulation and the mechanism is thought to involve stimulation of gamma-aminobutyric acid (GABA), which is the main inhibitory neurotransmitter in the brain. Magnesium also inhibits the activation of the N-methyl-D-aspartate (NMDA) receptor, which regulates a calcium channel in cells involved in the excitatory state, and is its activation is implicated in anxiety and panic disorders. Magnesium is thought to dampen down this excitatory and anxious state to promote relaxation and sleep13, 15. Magnesium aspartate is more bioavailable than some other forms of magnesium like magnesium oxide or sulphate because it is more soluble and better absorbed in the gut.16

What are the Contraindications/Interactions of Sleep Science?

You should always check the ingredients for known allergies and to ensure you do not have any allergies or sensitivities to these ingredients. Stop using if you develop any irritation or allergy while taking Sleep Science. Always read the label and use as directed, if in doubt seek advice from your healthcare professional.

Side effects

Sleep Science is considered well tolerated and no side effects have been reported.

Do not use:

If you are pregnant or are breastfeeding, without consultation with your doctor
Caution:

Use with caution if:

You are taking medicines that may interact with Sleep Science to increase sedative effects, without consultation with your doctor

What are the Directions for using Sleep Science?

Dosage:

Adults:

Take 1-2 capsules of Sleep Science 30 minutes before you are ready to go to sleep.

Adolescents (15 years +):

Take 1 capsule of Sleep Science 30 minutes before you are ready to go to sleep.

Product Size

30 Vegetable Capsules

References

The following references provide scientific support for the use of this product:
  1. Sleep-Wake Cycle: Its Physiology and Impact on Health. National Sleep Foundation. 
  2. Li Z, Srivastava P. Heat-shock proteins. Curr Protoc Immunol. 2004 Feb;Appendix 1:Appendix 1T. 
  3. O'connor TM, O'halloran DJ, F Shanahan F. The stress response and the hypothalamic‐pituitary‐adrenal axis: from molecule to melancholia. Q J Med 2000, 93, 323-333. 
  4. Ito T, Maeda T, Goto K, Miura T, Wakame K, et al. Enzyme-treated asparagus extract promotes expression of heat shock protein and exerts antistress effects. J Food Sci. 2014 (a) Mar;79(3):H413-9. 
  5. Ito T, Sato A, Ono T, Goto K, Maeda T. Isolation, structural elucidation, and biological evaluation of a 5-hydroxymethyl-2-furfural derivative, asfural, from enzyme-treated asparagus extract. J Agric Food Chem.2013 Sep 25;61(38):9155-9. 
  6. Ito T, Goto K, Takanari J, Miura T, Wakame K, et al. Effects of Enzyme-Treated Asparagus Extract on Heat-Shock Protein 70, stress indices, and sleep in healthy adult men. J Nutr Sci Vitaminol. 2014 (b)vol. 60(4), pp. 283-90.
  7. Takanari J, Nakahigashi J, Sato A, Waki H, Miyazaki S, Uebaba K, Hisajima T. Effect of Enzyme-Treated Asparagus Extract (ETAS) on Psychological Stress in Healthy Individuals. J Nutr Sci Vitaminol (Tokyo).2016;62(3):198-205. 
  8. Sakurai T, Ito T, Wakame K, Kitadate K, Arai T, et al. Enzyme-treated Asparagus officinalis extract shows neuroprotective effects and attenuates cognitive impairment in senescence-accelerated mice. Natural Product Communications. 2014 vol. 9(1), pp. 101-106Chinese date
  9. Chen J, Liu X, Li Z, Qi A,1 Ping Yao P, et al. A Review of Dietary Ziziphus jujuba Fruit (Jujube): Developing Health Food Supplements for Brain Protection. Evid Based Complement Alternat Med. 2017:3019568.
  10. Gao Q.-H., Wu C.-S., Wang M. The jujube (Ziziphus jujube Mill.) fruit: a review of current knowledge of fruit composition and health benefits. Journal of Agricultural and Food Chemistry. 2013;61(14):3351–3363. 
  11. Wang LE, Cui XY, Cui SY, Cao JX, Zhang J, et al. Potentiating effect of spinosin, a C-glycoside flavonoid of Semen Ziziphi spinosae, on pentobarbital-induced sleep may be related to postsynaptic 5-HT(1A) receptors. Phytomedicine.2010 May;17(6):404-9. 
  12. Cao JX, Zhang QY, Cui SY, Cui XY, Zhang J, et al. Hypnotic effect of jujubosides from Semen Ziziphi Spinosae. J Ethnopharmacol.2010 Jul 6;130(1):163-6. 
  13. Boyle NB, Lawton C, Dye L. The Effects of Magnesium Supplementation on Subjective Anxiety and Stress—A Systematic Review Nutrients2017 May; 9(5): 429.
  14. Derom ML, Sayón-Orea C, Martínez-Ortega JM, Martínez-González MA Magnesium and depression: a systematic review. Nutr Neurosci.2013 Sep;16(5):191-206. 
  15. Abbasi B, Masud Kimiagar M, Khosro Sadeghniiat K, Shirazi MM, Hedayati M, Rashidkhani B. The effect of magnesium supplementation on primary insomnia in elderly: A double-blind placebo-controlled clinical trial. J Res Med Sci2012. Dec; 17(12): 1161–1169 
  16. National Institute for Health; Magnesium, Fact Sheet for Health Professionals