{"product_id":"artemis-healthy-heart-tea-30g","title":"Artemis Healthy Heart Tea | 30g","description":"\u003ch2\u003eArtemis Healthy Heart Tea\u003c\/h2\u003e\r \u003ch3\u003e\r What is Healthy Heart Tea?\u003c\/h3\u003e\r \u003cp\u003e\r Healthy Heart Tea is a blend of natural herbal ingredients that helps protect the heart from damage and keep it strong, to support you in living a healthy lifestyle, which includes good nutrition and regular exercise.  Healthy Heart Tea promotes a healthy cardiovascular system.  \u003c\/p\u003e\r \u003ch3\u003e\r Why use Healthy Heart Tea?\u003c\/h3\u003e\r \u003cp\u003e\r Maintaining a healthy heart and circulation are key to preventing cardiovascular disease, which includes a range of diseases that can result in heart attack and stroke.  Healthy Heart Tea is a blend of natural herbal ingredients with properties that help protect the heart from damage and keeps the circulation flowing, while helping you feel calm and relaxed.  Healthy Heart Tea can support you in living a healthy lifestyle, which includes good nutrition and regular exercise, to promotes a healthy cardiovascular system. \u003c\/p\u003e\r \u003ch3\u003e\r What are the Key benefits of Healthy Heart Tea?\u003c\/h3\u003e\r \u003cul\u003e\r     \u003cli\u003eTraditional medicinal plant formula \u003c\/li\u003e\r     \u003cli\u003eNatural ingredients that help protect the heart from damage\u003c\/li\u003e\r     \u003cli\u003eBlend of natural ingredients that promote cardiovascular health\u003c\/li\u003e\r     \u003cli\u003eNatural ingredients with calming relaxing properties\u003c\/li\u003e\r     \u003cli\u003eAll ingredients are certified organic, GE free and vegan\u003c\/li\u003e\r     \u003cli\u003eDoes not contain sugar or artificial sweeteners\u003c\/li\u003e\r     \u003cli\u003eDoes not contain added colours, flavours, preservatives, gluten, wheat or dairy\u003c\/li\u003e\r \u003c\/ul\u003e\r \u003ch4\u003e\r What is oxidative stress?\u003c\/h4\u003e\r \u003cp\u003e\r An oxygen free radicle is an oxygen molecule that contains a single electron, which makes it highly reactive as it scavenges to find another unpaired electron, causing damage to lipids, proteins and DNA.  These free radicles, known as reactive oxygen species (ROS) include superoxide and hydrogen peroxide and they are also generated under normal metabolic conditions as they are needed for cellular process.  There are also external factors that increase generation of free radicles including smoking, alcohol and ultraviolet irradiation from the sun.  However, under normal conditions the body’s antioxidant defence system eliminates ROS so that there is a balance between generation and elimination of free radicles.  If more free radicles are generated than eliminated this causes oxidative stress which is damaging to the body and is implicated in the pathogenesis of cardiovascular disease, including congestive heart failure and atherosclerosis (blocked arteries), also hypertension (high blood pressure), which can result in heart attack and stroke.  \u003c\/p\u003e\r \u003ch4\u003e\r What is an antioxidant?\u003c\/h4\u003e\r \u003cp\u003e\r An antioxidant is a substance that that protects the body from damage due oxidative stress, caused by free radicles by preventing harmful oxidising reactions.  Endogenous antioxidants include the enzymes glutathione peroxidase, an intracellular antioxidant found is most tissues that acts as a free radicle scavenger to stabilise ROS by reducing hydrogen peroxide to water.  Superoxide dismutase is another powerful cellular antioxidant that protects against ROS like superoxide.  Nitric oxide is important for maintaining vascular tone and superoxide dismutase also prevents production of ROS molecules from nitric oxide, which causes damage to the vascular endothelial cells that line the blood vessels.  Thioredoxin reductase modulates the balance between oxidation and reduction (or the generation and mopping up of free radicles), since some ROS are also important for normal cellular processes like intracellular signalling mechanisms and destruction of pathogens by immune cells.  There are many antioxidant molecules found in plants that can contribute to the important processes of protecting cells against oxidative stress.  Natural plant antioxidants are mainly polyphenols such as flavonoids, procyanidins (proanthocanidins), lignans and stilbenes; triterpenoid; vitamins such as vitamins C and E, and carotenoids like xanthophylls and carotenes\u003csup\u003e1, 2.   \u003c\/sup\u003e\u003c\/p\u003e\r \u003ch4\u003e\r What is anxiety?\u003c\/h4\u003e\r \u003cp\u003e\r Anxiety is a normal reaction to everyday events such as financial worries, a pending job interview or relationship problems.  Symptoms of anxiety can include gastrointestinal problems, shortness of breath, restlessness, sweating, lethargy, problems sleeping and frequent urination.  Anxiety is usually related to a specific event or a recent trauma, and symptoms should relent once the event has passed or been resolved.  However, if the feeling of anxiety persists, it could be due to a more serious condition and a health professional should be consulted.  \u003c\/p\u003e\r \u003ch4\u003e\r What is an anxiolytic?\u003c\/h4\u003e\r \u003cp\u003e\r An anxiolytic is a substance that can relieve anxiety, aid sleep, or have a calming effect. \u003c\/p\u003e\r \u003ch4\u003e\r What is stress?\u003c\/h4\u003e\r \u003cp\u003e\r Stress is a natural physiological response going back to our caveman days designed to alert the body to danger and respond to it; also known as the “flight or fight response”.  During the stress response, the brain signals the adrenal glands to release the hormones cortisol and adrenaline, and these hormones cause several changes throughout the body such as increased heart rate, rapid breathing and increased blood glucose, which prepare the body for a rapid response.  Stress also affects our emotions, mood, behaviour and many of our body systems, including our cardiovascular, respiratory, gastrointestinal and immune systems.  Normally the stress induced changes will settle back to normal once the cause of the stress has gone.  However, constant or extreme stress can become a chronic condition and lead to serious health problems including anxiety disorder and depression and may aggravate other conditions and compromise cardiovascular health.   \u003c\/p\u003e\r \u003ch4\u003e\r What is a cardiotonic?\u003c\/h4\u003e\r \u003cp\u003e\r A cardiotonic is a substance that increase the efficiency of the heart and improves contraction of the heart muscle, resulting in improved blood flow to all tissues of the body.\u003c\/p\u003e\r \u003ch4\u003e\r What is a cardioprotective?\u003c\/h4\u003e\r \u003cp\u003e\r A cardioprotective is a substance that protects the heart muscle from damage that can lead to heart disease. \u003c\/p\u003e\r \u003ch4\u003e\r What is GABA (gamma-Aminobutyric acid)?\u003c\/h4\u003e\r \u003cp\u003e\r A neurotransmitter is a brain chemical that allows nerve cells to communicate.  Gamma-aminobutyric acid (GABA), is the main inhibitory neurotransmitter in the brain.  Glutamate is the main excitatory neurotransmitter in the brain.  Whereas glutamate has a stimulating effect on the brain, GABA has a sedating and calming effect on the brain.  These neurotransmitters bind to specific receptors and can be regulated by various external chemicals.  For example, alcohol decreases glutamate activity, caffeine increases glutamate and decreases GABA release, tranquilizers and sleeping pills like benzodiazepines increase GABA activity.\u003c\/p\u003e\r \u003ch3\u003e\r What are the Ingredients of Healthy Heart Tea?\u003c\/h3\u003e\r \u003ch4\u003eKey Ingredients:\u003c\/h4\u003e\r \u003ch5\u003eHawthorn\u003cem\u003e (Crataegus spp):\u003c\/em\u003e\n\u003c\/h5\u003e\r \u003cp\u003e\r Hawthorn, also known as Mayflower or Mayblossom is a large genus of shrubs and trees belonging to the Rosaceae family that are found mainly in the northern temperate zones of North America, Asia, and Europe.  Hawthorn has been used for centuries as a traditional medicine for treating heart disease and strengthening the heart.  This use has continued in contemporary medicine and Hawthorn is widely used as a cardiotonic and for its cardioprotective and anti-hypertensive properties; also, for its antioxidant, antimicrobial, anti-inflammatory, and gastroprotective effects.  Hawthorn extract is rich in many important compounds including antioxidants like triterpenes, procyanidins proanthocanidins, flavonoids, tannins, vitamin C, and glycosides.  Animal models and in vitro studies have demonstrated cardioprotective effects due to antioxidant and anti-inflammatory properties of Hawthorn extract and its ability to induce endogenous antioxidants in heart muscle cells, reducing overall oxidative stress.  Other cardioprotective effects of Hawthorn extract in these studies include modulating the balance between vasoconstrictors and vasodilators in endothelial cells improving blood flow, increasing contractile force of heart muscle cells (positive inotropic effect), counteracting arrythmia (irregular heartbeat), inhibition of cardiac hypertrophy, which is over enlargement of the heart due to high blood pressure or cardiovascular disease and lowering of blood lipids\u003csup\u003e3, 4, 5, 6, 7, 8.  \u003c\/sup\u003eSeveral clinical studies, particularly two large trials known as the SPICE trial and the HERB CHF trial, have demonstrated that Hawthorn extract may be beneficial in high risk patients with serious congestive heart failure, in conjunction with regular heart medications, to reduce symptoms and increase cardiac function, quality of life and exercise tolerance, with a good safety record\u003csup\u003e3, 7, 8.   \u003c\/sup\u003e\u003c\/p\u003e\r \u003ch5\u003e\r Lemon Balm \u003cem\u003e(Melissa officinalis):\u003c\/em\u003e\n\u003c\/h5\u003e\r \u003cp\u003e\r Lemon Balm is a flowering plant belonging to the Lamiaceae (mint) family that is native to large areas of Europe and Asia.  As a traditional medicine Lemon Balm has been used for it calming and relaxing properties, as a carminative, sedative, as a tonic and for improving memory\u003csup\u003e9, 10. \u003c\/sup\u003e It is used in contemporary herbal medicine as an herbal supplement for its effect on mood, cognitive function and anxiety, to reduce stress and ease anxiety and to help with sleeping disorders; also, to treat gastrointestinal problems\u003csup\u003e11, 12.  \u003c\/sup\u003eClinical and preclinical studies have demonstrated effective use of lemon balm as an anxiolytic to treat anxiety disorders, relieve stress and help improve sleep disorders\u003csup\u003e10, 13, 14, 15.\u003c\/sup\u003e  Extracts of Lemon Balm contain several bioactive components including citronellal, citronellol, linalool, rosmarinic acid, and several flavonoids.  Laboratory studies have demonstrated that Lemon Balm extract binds to several brain receptors, including the gamma-aminobutyric acid (GABA) receptor, which is the major inhibitory neurotransmitter in the central nervous system and this is thought to contribute to its anxiolytic effect and calming effect \u003csup\u003e14, 17, 18, 19.  \u003c\/sup\u003eLemon balm has also been found to have cardioprotective properties in preclinical studies, which may be due to its antioxidant effects, as demonstrated in an animal study\u003csup\u003e16.  \u003c\/sup\u003eVasorelaxant effects of Lemon Balm in vitro were demonstrated and thought to work by interaction of rosmarinic acid with the nitric oxide pathway in the vascular endothelium\u003csup\u003e17.  \u003c\/sup\u003e\u003c\/p\u003e\r \u003ch5\u003e\r Motherwort\u003cem\u003e (Leonurus cardiaca):\u003c\/em\u003e\n\u003c\/h5\u003e\r \u003cp\u003e\r Motherwort is a perennial herbaceous plant belonging to the Lamiaceae (mint) family, grown throughout Europe as well as other locations worldwide for its use in traditional herbal medicine for heart problems, nervous disorders, women’s health problems and digestive disorders.  Motherwort contains several pharmacologically active compounds including flavonoid and diterpinoids (aromatic essential oils), iridoid glycosides, seterols and tannins, and has several biological properties including antibacterial, antioxidant, anti-inflammatory, neuroprotective, analgesic, sedative and hypotensive (lowering blood pressure)\u003csup\u003e18.  \u003c\/sup\u003eLeonurine is an alkaloid extracted from Motherwort which has several bioactive properties identified in animal models, including antidepressant-like and anxiolytic effects, mild vasodilator and relaxing effect on smooth muscles;\u003csup\u003e19, 20\u003c\/sup\u003e An in vitro study with isolated aortic rings, demonstrated that leonurine in Motherwort extract had vasorelaxation properties, by acting on the calcium channels\u003csup\u003e21.\u003c\/sup\u003e  Also, cardioprotective effects of Motherwort extract due to antioxidant activity were indicated by in vitro studies\u003csup\u003e22.  \u003c\/sup\u003eA review of preclinical and clinical studies indicated that Motherwort extract also has cardiotonic properties\u003csup\u003e23.  \u003c\/sup\u003e\u003c\/p\u003e\r \u003ch5\u003e\r Passionflower \u003cem\u003e(Passiflora incarnata):\u003c\/em\u003e\n\u003c\/h5\u003e\r \u003cp\u003e\r Passionflower is a perennial vine belonging to the Passifloraceae family and its many species are found mainly in Central and South America.  Passionflower has been used as a traditional herbal remedy for anxiety, as a sedative and to help with sleep disturbance.  Several preclinical experiments have demonstrated pharmacological activities of Passionflower extract, and these include anxiolytic and sedative properties, which have been supported in some clinical studies\u003csup\u003e24. \u003c\/sup\u003e A placebo controlled study has demonstrated that a tea containing a low dose of Passionflower improves sleep in healthy adults with mild fluctuations in sleep quality\u003csup\u003e25. \u003c\/sup\u003e A clinical study demonstrated that Passionflower extract was as effective as the prescription drug oxazepam for the management of generalized anxiety disorder\u003csup\u003e26.\u003c\/sup\u003e  In a clinical study with patients suffering from nervous restlessness, passionflower extract improved resistance to stress and quality of life\u003csup\u003e27.\u003c\/sup\u003e  The pharmacological effects of Passionflower were demonstrated in laboratory experiments to be mediated by modulation of the GABA system\u003csup\u003e28.  \u003c\/sup\u003e\u003c\/p\u003e\r \u003ch5\u003e\r St John's Wort\u003cem\u003e (Hypericum perforatum):\u003c\/em\u003e\n\u003c\/h5\u003e\r \u003cp\u003e\r St John’s Wort is a perennial flowering plant with characteristic yellow flowers belonging to the Hypericaceae family.  It is native to parts of Europe, Asia and North Africa, and has been used for centuries to treat nervous conditions.  Clinical studies have supported the use of St John’s Wort as a mood enhancer and have shown that it is an effective antidepressant that works in a similar way to prescription antidepressant medications\u003csup\u003e29, 30. \u003c\/sup\u003e It is known that St John’s Wort can interact with several prescription medications and alter their effectiveness and increase side effects, therefore caution is advised\u003csup\u003e31, 32.\u003c\/sup\u003e  Extracts of St John’s Wort contain several bioactive components including hypericin, hyperforin and flavonoids that contribute to its antidepressant effects\u003csup\u003e33.  \u003c\/sup\u003eThe mechanism of action includes binding to receptors for neurotransmitters involved in regulating mood, including serotonin and dopamine, and increasing levels of serotonin in the brain, in a similar way to conventional SSRI (selective serotonin reuptake inhibitor) antidepressants\u003csup\u003e30, 32, 34.  \u003c\/sup\u003e\u003c\/p\u003e\r \u003ch3\u003e\r What are the Contraindications\/Interactions of Healthy Heart Tea?\u003c\/h3\u003e\r \u003cp\u003e\r There are no documented herb-drug interactions within the recommended dosage.  However, you should always check the ingredients for known allergies and to ensure you do not have any allergies or sensitivities to these ingredients.  Stop using if you develop any irritation or allergy while taking Healthy Heart Tea.  Always read the label and use as directed or seek advice from your healthcare professional.\u003c\/p\u003e\r \u003ch4\u003e\r Caution:\u003c\/h4\u003e\r \u003ch5\u003e\r Healthy Heart Tea should be used with caution if you:\u003c\/h5\u003e\r \u003cul\u003e\r     \u003cli\u003eare pregnant or while breast-feeding as effects of St John Wort in pregnancy are not established and hawthorn can cause uterine stimulation\u003c\/li\u003e\r     \u003cli\u003eare taking prescription medications for depression and other prescription medications without talking to your doctor, as St John’s Wort has the potential to interact with some prescription drugs \u003c\/li\u003e\r     \u003cli\u003eare taking sedative medications as Passionflower and Motherwort can increase sedation\u003c\/li\u003e\r     \u003cli\u003eare taking blood pressure medications as Passionflower can have blood pressure lowering effects\u003c\/li\u003e\r     \u003cli\u003eyou burn easily in the sun as Motherwort can increase sensitivity to the UV light\u003c\/li\u003e\r \u003c\/ul\u003e\r \u003ch3\u003e\r What are the Directions for using Healthy Heart Tea?\u003c\/h3\u003e\r \u003cp\u003e\r Use one level teaspoon (1g) of Healthy Heart Tea powder per cup (150ml) and infuse with boiling water for 5-10 minutes.  \u003c\/p\u003e\r \u003ch4\u003e\r Dosage:\u003c\/h4\u003e\r \u003cp\u003e\r Take 1-3 cups daily depending on the level of support you need.\u003c\/p\u003e\r \u003ch4\u003e\r Special instructions\u003c\/h4\u003e\r \u003ch5\u003e\r For best results:\u003c\/h5\u003e\r \u003cul\u003e\r     \u003cli\u003eShake the can before opening, as the contents may settle. \u003c\/li\u003e\r     \u003cli\u003eDo not microwave. \u003c\/li\u003e\r     \u003cli\u003e To avoid external contamination close can immediately after use. \u003c\/li\u003e\r     \u003cli\u003eStore in the fridge in hot and humid climates and keep away from heat and moisture. \u003c\/li\u003e\r \u003c\/ul\u003e\r \u003ch3\u003eProduct Size\u003c\/h3\u003e\r \u003cp\u003e\r 30g\u003c\/p\u003e\r \u003ch3\u003e\r References\u003c\/h3\u003e\r \u003ch5\u003e\r The following references provide scientific support for the use of this product:\u003c\/h5\u003e\r \u003col\u003e\r     \u003cli\u003eP, Li Y, Meng X, Zhou T, Zhou Y, et al.  Natural Antioxidants in Foods and Medicinal Plants: Extraction, Assessment and Resources Xu D-Int. J. Mol. Sci. 2017, 18, 96;\u003c\/li\u003e\r     \u003cli\u003eKasote DM, Katyare SS, Hegde MV, Hanhong Bae H.  Significance of Antioxidant Potential of Plants and its Relevance to Therapeutic Applications Int. J. Biol. Sci. 2015, Vol. 11\u003c\/li\u003e\r     \u003cli\u003eZorniak M, Szydlo B, Krzeminski TF. Crataegus Special Extract Ws 1442: Up-To-Date Review of Experimental and Clinical Experiences.  J Physiol Pharmacol. 2017 Aug;68(4):521-526.\u003c\/li\u003e\r     \u003cli\u003eCuevas-Durán RE, Medrano-Rodríguez JC, Sánchez-Aguilar M, Soria-Castro E, Rubio-Ruíz ME, et al. Extracts of Crataegus oxyacantha and Rosmarinus officinalis Attenuate Ischemic Myocardial Damage by Decreasing Oxidative Stress and Regulating the Production of Cardiac Vasoactive Agents. Int J Mol Sci.2017 Nov 14;18(11). pii: E2412.\u003c\/li\u003e\r     \u003cli\u003eKallassy H, Fayyad-Kazan M, Makki R, El-Makhour Y, Hamade E, et al.  Chemical Composition, Antioxidant, Anti-Inflammatory, and Antiproliferative Activities of the Plant Lebanese Crataegus Azarolus L.  Med Sci Monit Basic Res.2017 Aug 3;23:270-284. \u003c\/li\u003e\r     \u003cli\u003eRanjbar K, Zarrinkalam E, Salehi I, Komaki A, Fayazi B.  Cardioprotective effect of resistance training and Crataegus oxyacantha extract on ischemia reperfusion-induced oxidative stress in diabetic rats.Biomed Pharmacother.2018 Apr;100:455-460. \u003c\/li\u003e\r     \u003cli\u003eHolubarsch CJF, Colucci WS, Eha J.  Benefit-Risk Assessment of Crataegus Extract WS 1442: An Evidence-Based Review. Am J Cardiovasc Drugs.2018 Feb;18(1):25-36.\u003c\/li\u003e\r     \u003cli\u003eWang J, Xiong X, Feng B. Effect of Crataegus usage in cardiovascular disease prevention: an evidence-based approach. Evid Based Complement Alternat Med. 2013;2013:149363.\u003c\/li\u003e\r     \u003cli\u003eShakeri A, Sahebkar A, Javadi B.  Melissa officinalis L. - A review of its traditional uses, phytochemistry and pharmacology. J Ethnopharmacol 2016 Jul 21;188:204-28. \u003c\/li\u003e\r     \u003cli\u003eScholey A, Gibbs A, Neale C, Perry N, et al. Anti-stress effects of lemon balm-containing foods. Nutrients. 2014 Oct 30;6(11):4805-21\u003c\/li\u003e\r     \u003cli\u003eMoradkhani H, Sargsyan E, Bibak H. 2, Naseri B, Sadat-Hosseini M, Fayazi-Barjin A, Meftahizade H.  Melissa officinalis L., a valuable medicine plant: A review Journal of Medicinal Plants Research Vol. 4(25), pp. 2753-2759, 29 December Special Review, 2010\u003c\/li\u003e\r     \u003cli\u003eAbascal K, Yarnell E.  Nervine Herbs for Treating Anxiety.  Alternative and Complementary Therapies December 2004; 309-315. \u003c\/li\u003e\r     \u003cli\u003eSarris J, McIntyre E, Camfield DA. Plant-based medicines for anxiety disorders, Part 1: a review of preclinical studies. CNS Drugs 2013 Mar;27(3):207-19. \u003c\/li\u003e\r     \u003cli\u003eSarris J, McIntyre E, Camfield DA.  Plant-Based Medicines for Anxiety Disorders, Part 2: A Review of Clinical Studies with Supporting Preclinical Evidence.  CNS Drugs 2013 April;27(3):301-19 \u003c\/li\u003e\r     \u003cli\u003eShi Y, Dong J-W, Zhao J-H, Tang L-N, Zhang J-J.  Herbal Insomnia Medications that Target GABAergic Systems: A Review of the Psychopharmacological Evidence.  Curr Neuropharmacol2014 May; 12(3): 289–302\u003c\/li\u003e\r     \u003cli\u003eJoukar S, AsadipourH, Sheibani M, Najafipour H, Dabiri S.  The effects of Melissa officinalis (lemon balm) pretreatment on the resistance of the heart to myocardial injury. Pharmaceutical Biology, 2016 vol. 54, no. 6, 1005–1013. \u003c\/li\u003e\r     \u003cli\u003eErsoyaI S, Orhan I, Turan NN, Şahan G, Ark M, Tosuna F.  Endothelium-dependent induction of vasorelaxation by Melissa officinalis L. ssp. Officinalis in rat isolated thoracic aorta\u003c\/li\u003e\r     \u003cli\u003eWojtyniak K, Szymański M, Matławska I Leonurus cardiaca L. (motherwort): a review of its phytochemistry and pharmacology. Phytother Res. 2013 Aug;27(8):1115-20. \u003c\/li\u003e\r     \u003cli\u003eRezaei A, Issabeagloo E, Kordlar J. Study of Sedative, Preanaesthetic and Anti-anxiety Effects of Herbal Extract of Motherwort (Leonuruscardiac) in Comparison with Diazepam in rat.  Bull. Env. Pharmacol. Life Sci., Vol 3 (2) January 2014: 67-71\u003c\/li\u003e\r     \u003cli\u003eJia M, Li C, Zheng Y, Ding X, Chen M, et al.  Leonurine Exerts Antidepressant-Like Effects in the Chronic Mild Stress-Induced Depression Model in Mice by Inhibiting Neuroinflammation.  International Journal of Neuropsychopharmacology (2017) 20(11): 886–895\u003c\/li\u003e\r     \u003cli\u003eChen CX, Kwan CY: Endothelium-independent vasorelaxation by leonurine, a plant alkaloid purified from Chinese motherwort, Life Sci 68:953-60, 2001 \u003c\/li\u003e\r     \u003cli\u003eBernatoniene J, Kopustinskiene DM, Jakstas V, Majiene D, Baniene R, et al.  The effect of Leonurus cardiaca herb extract and some of its flavonoids on mitochondrial oxidative phosphorylation in the heart. Planta Med.2014 May;80(7):525-32 \u003c\/li\u003e\r     \u003cli\u003eOrhan IE, Gokbulut A, Senol FS.  Adonis sp., Convallaria sp., Strophanthus sp., Thevetia sp., and Leonurus sp. - Cardiotonic Plants with Known Traditional Use and a Few Preclinical and Clinical Studies.  Curr Pharm Des.2017;23(7):1051-1059 \u003c\/li\u003e\r     \u003cli\u003eMiroddi M, Calapai G, Navarra M, Minciullo PL, Gangemi S. Passiflora incarnata L.: ethnopharmacology, clinical application, safety and evaluation of clinical trials. J Ethnopharmacol 2013 Dec 12;150(3):791-804 \u003c\/li\u003e\r     \u003cli\u003eNgan A, Conduit R. A double-blind, placebo-controlled investigation of the effects of Passiflora incarnata (passionflower) herbal tea on subjective sleep quality. Phytother Res 2011 Aug;25(8):1153-9. \u003c\/li\u003e\r     \u003cli\u003eAkhondzadeh S, Naghavi HR, Vazirian M, Shayeganpour A, Rashidi H, Khani M.  Passionflower in the treatment of generalized anxiety: A pilot double-blind randomized controlled trial with oxazepam. J Clin Pharm Ther 2001;26:363–367. \u003c\/li\u003e\r     \u003cli\u003eGibbert J, Kreimendahl F, Lebert J, Rychlik R, Trompetter I.  Improvement of Stress Resistance and Quality of Life of Adults with Nervous Restlessness after Treatment with a Passion Flower Dry Extract. Complement Med Res.2017;24(2):83-89. \u003c\/li\u003e\r     \u003cli\u003eAppel K, Rose T, Fiebich B, Kammler T, Hoffmann C, Weiss G.  Modulation of the γ-aminobutyric acid (GABA) system by Passiflora incarnata L. Phytother Res. 2011 Jun;25(6):838-43. \u003c\/li\u003e\r     \u003cli\u003eApaydin EA, Maher AR, Shanman R, Booth MS, Miles JN, Sorbero ME, Hempel S. A systematic review of St. John's wort for major depressive disorder. Syst Rev 2016 Sep 2;5(1):148. \u003c\/li\u003e\r     \u003cli\u003eWurglics M, Schubert-Zsilavecz M. Hypericum perforatum: a 'modern' herbal antidepressant: pharmacokinetics of active ingredients. Clin Pharmacokinet 2006;45(5):449-68.\u003c\/li\u003e\r     \u003cli\u003eDugoua JJ, Mills E, Perri D, Koren G. Safety and efficacy of St. John's wort (hypericum) during pregnancy and lactation. Can J Clin Pharmacol 2006 Fall;13(3):e268-76. \u003c\/li\u003e\r     \u003cli\u003eCaccia S. Antidepressant-like components of Hypericum perforatum extracts: an overview of their pharmacokinetics and metabolism. Curr Drug Metab 2005 Dec;6(6):531-43.\u003c\/li\u003e\r     \u003cli\u003eNahrstedt A Butterweck V.  Biologically active and other chemical constituents of the herb of Hypericum perforatum L. Pharmacopsychiatry 1997 Sep;30 Suppl 2:129-34 \u003c\/li\u003e\r     \u003cli\u003eLundstrom K, Pham HT, Dinh LD.  Interaction of Plant Extracts with Central Nervous System Receptors. Medicines (Basel) 2017 Feb 23;4(1).    \u003c\/li\u003e\r \u003c\/ol\u003e\r \u003cp\u003e \u003c\/p\u003e\r \u003cbr\u003e","brand":"Artemis","offers":[{"title":"30g","offer_id":31177900916781,"sku":"00645-30g","price":19.57,"currency_code":"NZD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0268\/9954\/6157\/products\/1120536.jpg?v=1573461812","url":"https:\/\/nz-nutristrong.myshopify.com\/products\/artemis-healthy-heart-tea-30g","provider":"NZ NutriStrong","version":"1.0","type":"link"}