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Artemis Cool and Calm Tea | 30g

Artemis Cool and Calm Tea | 30g

$19.57
$19.57
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Artemis Cool and Calm Tea

What is Cool  and Calm Tea?

Menopause can be a difficult time for women as mood and sleep become affected by fluctuating hormones. Cool and Calm Tea is a blend of natural herbal ingredients that support women through natural hormonal changes by helping to manage irritability and mood swings, regulating temperature imbalances and promoting healthy sleep patterns.

Why use Cool and Tea?

As menopause approaches, hormones levels change as oestrogen and progesterone, the hormones that regulate the cycle of ovulation and menstruation fall, and the regular menstrual cycle ceases. A lack of oestrogen causes a range of symptoms associated with menopause, including hot flushes, night sweats, sleep problems, vaginal dryness, headaches, mood swings, lack of concentration and loss of energy, as well as changes such as loss of bone mass. Cool and Calm Tea is a blend of natural herbal ingredients that support women through the natural hormonal changes of menopause by helping to manage irritability and mood swings, regulating temperature imbalances and promoting healthy sleep patterns.

What are the Key Benefits of Cool and Calm Tea?

  • Traditional medicinal plant formula 
  • Helps manage menopausal symptoms
  • Provides natural phytoestrogens to supplement loss of oestrogen
  • Provides natural support to help manage stress and mood swings
  • Natural ingredients that reduce stress and anxiety during menopausal transitional changes
  • Natural ingredients that promote relaxation and sleep
  • Suitable for women in perimenopause and menopause
  • Does not contain sugar or artificial sweeteners
  • Does not contain added colours, flavours, preservatives, gluten, wheat or dairy

What is menopause?

Menopause is a natural stage in a woman’s life, also known as climacteric, that usually begins around the age of 50, when oestrogen levels fall and menstruation stops. Menopause is defined as having been one year since the last menstrual bleed. Symptoms of menopause are caused by lack of oestrogen and include hot flushes, sweating, sleep disturbances, vaginal dryness, headaches, mood swings, lack of concentration and loss of energy, as well as changes such as loss of bone mass.

What causes hot flushes?

Hot flushes are the sudden and overwhelming feelings of warmth that are a common symptom of menopause and are usually accompanied by sweating and blotchy redness of the skin. These vasomotor symptoms of menopause are caused by falling levels of oestrogen and increasing levels of follicle stimulating hormone (FSH). This influences the temperature regulatory centres in the hypothalamus of the brain, by increasing sensitivity to small changes in body temperature, resulting in dilation of blood vessels in the skin, which increases blood flow and body temperature.

What are phytoestrogens?

A Phytoestrogen is a plant derived compound that is similar in structure to endogenous (naturally occurring) oestradiol also known as 17-β-oestradiol or E2. Phytoestrogens can bind to the oestrogen receptor on cells that are responsive to oestrogen and can mimic some of the activities of endogenous oestrogen, although theirs effect are much weaker. These include effects on bone, ovarian, vascular and endometrial tissue, which may help improve menopausal symptoms due to low levels of natural oestrogen1, 2.

What is an anxiolytic?

An anxiolytic is a substance that can relieve anxiety, aid sleep, or have a calming effect.

What are the Ingredients of Cool and Calm Tea?

Key Ingredients:

Hops (Humulus lupulus):

Hops are a flowering plant belonging to the hemp family (Cannabaceae), and are native to Europe, western Asia and North America. Hops have been used in traditional medicine for many ailments including insomnia, anxiety, digestive complaints, infections and muscle spasms, due to their many properties including sedative, calming, anti-inflammatory, antibacterial, stomachic (assisting digestion), and spasmolytic properties3. The sedative characteristics hops in combination with valerian have been demonstrated in clinical studies where sleep quality and sleep onset were improved4,5,6. Several active ingredients have been identified that are responsible for the neuropharmacological effects of hops, including flavonoids and volatile oils3. Animal studies have indicated that the mechanism of action includes binding to receptors in the CNS for melatonin and serotonin that are neurotransmitters related to circadian rhythm and sleep regulation7. A specific compound called 8-Prenylnaringenin (8-PN) has been identified in hop extract belonging to a group of prenylated flavonoids and found to have potent phytoestrogen activity, with strong binding to the oestrogen receptor8, 9. When tested in animal studies and clinical trials, 8-PN was found to be effective in relieving menopausal symptoms including hot flushes10.

Lavender (Lavandula angustifolia):

Lavendula, commonly known as English Lavender, is an aromatic shrub belonging to the family Lamiaceae that is native to Mediterranean regions and grown the world over for its fragrant purple flowers. Lavender has been used for its medicinal properties for centuries including as a cleansing and purifying herb by the Romans, in traditional herbal medicine for inducing relaxation, treating parasitic infections, healing burns, soothing insect bites, and the oil is used to help with depression, sleep problems and mood swings11. The main pharmacologically active compound identified in lavender essential oil is linalool, a monoterpene that has a calming sedative effect in animal models12. Lavender also has anxiolytic effects as demonstrated in animal models and clinical studies. Several mechanisms of action for lavender in reducing anxiety have been suggested including blocking the binding of gamma-aminobutyric acid (GABA), which is the main inhibitory neurotransmitter in the brain, stimulation of the cholinergic system to increase acetylcholine levels in the brain, binding to N-methyl-D-aspartate (NMDA) receptors in the brain, which regulates the action of the excitatory neurotransmitter glutamate and regulating serotonin levels in the brain11, 12, 13, 14, 15.

Licorice root (Glycyrrhiza glabra):

Licorice is derived from the root of the herbaceous perennial plant Glycyrrhiza glabra belonging to the Legume family. It is native to parts of Europe and Asia and the dried roots of the Licorice plant have been used in traditional medicine in several ancient cultures16. It was used in traditional oriental medicine to replenish and invigorate and in other cultures to treat several ailments including peptic ulcers, liver diseases like hepatitis C, lung diseases and skin conditions. Licorice has several active ingredients, the main one being glycyrrhizin, a triterpenoid saponin, which has many medicinal properties including anti-inflammatory, anti-viral, antimicrobial, immunomodulatory antioxidative, cancer and liver protecting effects; also, protecting the stomach from irritation and spasm and relieving indigestion17, 18, 19. has also been found to have neuropharmacological properties such as neuroprotective, antidepressant, and anxiolytic effects, which are thought to be mediated by interacting with receptors in the brain, particularly of the GABA and dopamine system20. Liquiritigenin is another major pharmacologically active component in Licorice extract, which is a flavone with oestrogenic activity that binds to oestrogen receptors, as demonstrated in vitro and in animal models21, 22.

Motherwort (Leonurus cardiaca):

Motherwort is a perennial herbaceous plant belonging to the Lamiaceae family, grown throughout Europe as well as other locations worldwide for its use in traditional herbal medicine for heart problems, nervous disorders, women’s health problems and digestive disorders. Motherwort contains several pharmacologically active compounds including flavonoid and diterpinoids (aromatic essential oils), iridoids, seterols and tannins, and has several biological properties including antibacterial, antioxidant, anti-inflammatory, neuroprotective, analgesic, sedative and hypotensive (lowering blood pressure)23. Leonurine is an alkaloid extracted from Motherwort which has several bioactive properties identified in animal models, including antidepressant-like and anxiolytic effects, mild vasodilator and relaxing effect on smooth muscles;24, 25 also, analgesic properties26. A clinical study with Motherwort extract demonstrated an improvement in symptoms of depression and anxiety in patients with arterial hypertension, supporting its previously reported anxiolytic properties27.

Sage (Salvia officinalis):

Sage is a perennial shrub belonging to the Lamiaceae family that is native to the Mediterranean region and grown the world over for use as a cooking herb and for its medicinal properties for treating many disorders including seizure, ulcers, gout, rheumatism, inflammation, dizziness, tremor, paralysis, diarrhoea, and hyperglycaemia28, 29. A range of pharmacologically active compounds have been identified in sage extracts including coumarins, flavonoids, tannins, terpenes and alkaloids. Clinical and experimental studies have demonstrated a range of properties due to these bioactive compounds including antitumour, antioxidant, anti-inflammatory, antiseptic, memory enhancing, and metabolic effects such as lipid and blood sugar lowering effects28. In traditional and herbal medicine sage has been used for women’s health relating to hormonal fluctuations, including to help relieve hot flushes associated with menopause, and is thought to be due to the presence of estrogenic flavonoids in sage extracts30. This was supported by the findings of a clinical study in which menopausal flushing symptoms were reduced by sage31.

St John's Wort (Hypericum perforatum):

St John’s Wort is a perennial flowering plant with yellow flowers, native to parts of Europe, Asia and North Africa, and has been used for centuries to treat nervous conditions. Extracts of St John’s Wort contain several bioactive components that are thought to contribute to its pharmacological effects32, including hypericin, hyperforin and flavonoids that contribute to the antidepressant effects of St John's Wort. The mechanism of action includes binding to receptors for neurotransmitters involved in regulating mood, including serotonin and dopamine, and increasing levels of serotonin in the brain, in a similar way to conventional SSRI (selective serotonin reuptake inhibitor) antidepressants33, 34, 35. Clinical studies have supported the use of St John’s Wort as a mood enhancer and have shown that it is an effective antidepressant that works in a similar way to prescription antidepressant medications34, 36. Clinical studies investigating the effects of St John’s Wort extract on improving symptoms of menopause, reported some relief from symptoms and an improved quality of life in menopausal women37, 38, 39. St John’s Wort was also found to reduce the frequency, duration, and severity of hot flushes in menopausal women40.

Yarrow (Achillea millefolium):

Yarrow is a perennial flowering plant in the family Asteracea that grows in Europe, Asia, North Africa and North America, and is one of the most ancient known medicinal herbs. Extract of Yarrow has been found to contain many bioactive compounds, which are thought to contribute to the traditional uses for Yarrow that include diuretic, antiinflammatory and emmenagogic properties (promoting blood flow in the pelvic area), treating heart problems, gynecological disorders, wound healing and to prevent bleeding41, 42, 43. Certain compounds in Yarrow extract, particularly luteolin and apigenin, were found to have oestrogenic activity in in vitro, by binding to oestrogen receptors44.

What are the Contraindications/Interactions of Cool and Calm Tea?

There are no documented herb-drug interactions within the recommended dosage. However, you should always check the ingredients for known allergies and to ensure you do not have any allergies or sensitivities to these ingredients. Stop using if you develop any irritation or allergy while taking Cool and Calm Tea. Always read the label and use as directed or seek advice from your healthcare professional.

Caution:

If you are taking prescription medicines you should check your doctor before using Cool and Calm Tea, as St John’s Wort interacts with several prescription medication and can alter their effectiveness or increase side effects. These include antidepressants, HIV medications, immunosuppressant drugs for transplant, anticoagulants like warfarin, some heart medications, some anticonvulsants for epilepsy, and migraine treatments45.

Do not use:

Do not use if you are pregnant as motherwort can cause uterine contraction.

What are the Directions for using Cool and Calm Tea?

Use one level teaspoon (1g) of Cool and Calm Tea powder per cup (150ml) and infuse with boiling water for 5-10 minutes.

Dosage:

Take 2-3 cups per day until your new hormone regime has become established, which can take up to 3 months.

For best results:

Shake the can before opening, as the contents may settle.

Special instructions:
  • Do not microwave. 
  • Close can immediately after use to avoid external contamination. 
  • Store in the fridge in hot and humid climates and keep away from heat and moisture. 

References

The following references provide scientific support for the use of this product:
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  2. Usui T. Pharmaceutical prospects of phytoestrogens. Endocr J.2006 Feb;53(1):7-20.
  3. Zanoli P, Zavatti M. Pharmacognostic and pharmacological profile of Humulus lupulus L. J Ethnopharmacol 2008 Mar 28;116(3):383-96. 
  4. Morin CM, Koetter U, Bastien C, Ware JC, Wooten V. Valerian-hops combination and diphenhydramine for treating insomnia: a randomized placebo-controlled clinical trial. Sleep 2005 Nov;28(11):1465-71 
  5. Palmieri G, Contaldi P, Fogliame G. Evaluation of effectiveness and safety of a herbal compound in primary insomnia symptoms and sleep disturbances not related to medical or psychiatric causes. Nat Sci Sleep 2017 May 26;9:163-169. 
  6. Schiller H, Forster A, Vonhoff C, Hegger M, Biller A, Winterhoff H. Sedating effects of Humulus lupulus L. extracts. Phytomedicine.2006 Sep;13(8):535-41. 
  7. Abourashed EA, Koetter U, Brattström A. In vitro binding experiments with a valerian, hops and their fixed combination extract (ze91019) to selected central nervous system receptors. Phytomedicine. 2004;11(7–8):633–638. 
  8. Milligan SR, Kalita JC, A Heyerick A, Rong H, De Cooman L, De Keukeleire D. Identification of a Potent Phytoestrogen in Hops (Humulus lupulus L.) and Beer. The Journal of Clinical Endocrinology & Metabolism. Vol. 83, No. 6 1999.
  9. Milligan SR, Kalita JC, Pocock V, Van de Kauter V, Stevens JF, et al. The Endocrine Activities of 8-Prenylnaringenin and Related Hop (Humulus lupulus L.) Flavonoids. The Journal of Clinical Endocrinology & Metabolism. Vol. 85, No. 12 2000.
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  11. Koulivand PH, Ghadiri MK, Gorji A. Lavender and the Nervous System. Evid Based Complement Alternat Med 2013; 2013:681304
  12. Fismer KL, Pilkington K. Lavender and sleep: A systematic review of the evidence. European Journal of Integrative Medicine 4 (2012) e436–e447
  13. Schuwald AM, Noldner M, Wilmes T, Klugbauer N, Leuner K, Muller WE. Lavender Oil-Potent Anxiolytic Properties via Modulating Voltage Dependent Calcium Channels. s. PLoS ONE 2013 8(4): e59998. 
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  17. Asl MN, Hosseinzadeh H. Review of pharmacological effects of Glycyrrhiza sp. and its bioactive compounds. Phytother Res 2008 Jun;22(6):709-24. 
  18. Shamsa F, Ohtsuki K, Hasanzadeh E, Rezazadeh S. The Anti-inflammatory and Anti-viral Effects of an Ethnic Medicine: Glycyrrhizin. J Medicinal Plants Volume 9, Supplement No. 6, 2010
  19. Schröfelbauer B, Raffetseder J, Hauner M, Wolkerstorfer A, Ernst W, Szolar OH. Glycyrrhizin, the main active compound in liquorice, attenuates pro-inflammatory responses by interfering with membrane-dependent receptor signalling. Biochem J. 2009 Jul 15;421(3):473-82. 
  20. Zhao ZL, Kim SC, Liu HF, Wu YY, Li LB et al. Blockade of nicotine sensitization by methanol extracts of Glycyrrhizae radix mediated via antagonism of accumbal oxidative stress. BMC Complement Altern Med 2017 Nov 16;17(1):493. 
  21. Hajirahimkhan A, Simmler C, Yuan Y, Anderson JR, Chen SN. Evaluation of Estrogenic Activity of Licorice Species in Comparison with Hops Used in Botanicals for Menopausal Symptoms. PLoS One.2013 Jul 12;8(7):e67947
  22. Mersereau JE, Levy N, Staub RE, Baggett S, Zogovic T, et al. Liquiritigenin is a plant-derived highly selective estrogen receptor beta agonist. Mol Cell Endocrinol (2008)283: 49–57.
  23. Wojtyniak K, Szymański M, Matławska I Leonurus cardiaca L. (motherwort): a review of its phytochemistry and pharmacology. Phytother Res. 2013 Aug;27(8):1115-20. 
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  25. Jia M, Li C, Zheng Y, Ding X, Chen M, et al. Leonurine Exerts Antidepressant-Like Effects in the Chronic Mild Stress-Induced Depression Model in Mice by Inhibiting Neuroinflammation. International Journal of Neuropsychopharmacology (2017) 20(11): 886–895
  26. Rezaee-Asl M, Sabour M, Nikoui V, Ostadhadi S, Bakhtiarian A. The Study of Analgesic Effects of Leonurus cardiaca L. in Mice by Formalin, Tail Flick and Hot Plate Tests Int Sch Res Notices. 2014 Sep 1;2014:687697.
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