{"product_id":"artemis-arthro-ease-oral-liquid-200ml","title":"Artemis Arthro Ease Oral Liquid | 200ml","description":"\u003ch2\u003eArtemis Arthro Ease Oral Liquid\u003c\/h2\u003e\r \u003ch3\u003e\r What is Arthro Ease Oral Liquid?\u003c\/h3\u003e\r \u003cp\u003e\r Arthro Ease Oral Liquid is a traditional herbal medicine that provides natural support for painful joint. The combination of natural ingredients in Arthro Ease Oral Liquid work together to reduce chronic inflammation in conditions like arthritis, and helps relieve symptoms of inflammation in arthritic joint diseases.\r \u003c\/p\u003e\r \u003ch3\u003e\r Why use Arthro Ease Oral Liquid?\u003c\/h3\u003e\r \u003cp\u003e\r Swollen joints, reduced mobility and above all pain are all symptoms of arthritis, including rheumatoid arthritis, osteoarthritis and gout, another form of arthritis.  Arthro Ease Oral Liquid is a traditional herbal medicine that provides natural support for painful joints, as well as providing a holistic approach to relieving chronic joint pain and stiffness, by helping to prevent further joint destruction and reducing pain and inflammation characteristic of joint disorders.  Arthro Ease Oral Liquid is a pleasant tasting tonic that is gentle on the stomach and can be used for long-term relief.\r \u003c\/p\u003e\r \u003ch3\u003e\r What are the Key Benefits of Arthro Ease Oral Liquid?\u003c\/h3\u003e\r \u003cul\u003e\r     \u003cli\u003eTraditional medicinal plant formula \u003c\/li\u003e\r     \u003cli\u003eProvides natural support for joint health to help reduce joint destruction\u003c\/li\u003e\r     \u003cli\u003eProvides natural support for healthy kidney function to reduce build-up of uric acid\u003c\/li\u003e\r     \u003cli\u003eContains herbal ingredients with natural anti-inflammatory and analgesic properties\u003c\/li\u003e\r     \u003cli\u003eA pleasant tasting tonic with the natural flavouring of peppermint and ginger\u003c\/li\u003e\r     \u003cli\u003eAll ingredients are, GE free and vegan\u003c\/li\u003e\r     \u003cli\u003eDoes not contain sugar or artificial sweeteners\u003c\/li\u003e\r     \u003cli\u003eDoes not contain added colours, flavours, preservatives, gluten, wheat or dairy\u003c\/li\u003e\r \u003c\/ul\u003e\r \u003ch4\u003e\r What is arthritis?\u003c\/h4\u003e\r \u003cp\u003e\r Arthritis is a chronic (long-term) inflammatory disease of the joints that results in pain, swelling, stiffness and reduced joint mobility.  There are different forms of arthritis, which are determined by the cause.  Osteoarthritis or “wear and tear” of the joints is a common aging problem and is caused by disintegration of the cartilage that normally protects the ends of our joints.  Rheumatoid arthritis, also known as rheumatism, is an autoimmune disease (where the immune system attacks self) and is characterised by cartilage destruction and by inflammation of synovial tissue that lines our joints.  Several inflammatory mediators like cytokines and prostaglandins are increased in the joint tissues and are responsible for many of the destructive effects seen in arthritic joints.\r \u003c\/p\u003e\r \u003ch4\u003e\r What is gout?\u003c\/h4\u003e\r \u003cp\u003e\r Gout is a form of arthritis and is caused by high concentration of uric acid in the blood, which becomes deposited in small joints, most commonly the big toe.  Uric acid is produced from purines as a result of protein metabolism and is a waste product that is normally excreted by the kidneys, as the major component of urine.  A diet high in protein may contribute to gout, therefore, a low purine diet is recommended to help reduce risk of gout.\r \u003c\/p\u003e\r \u003ch4\u003e\r What is inflammation?\u003c\/h4\u003e\r \u003cp\u003e\r Inflammation is a complex mechanism for protecting the body from harmful pathogens or chemicals; also for cleaning up after tissue injury to start the healing process.  The inflammatory response involves several different blood cells of the immune system and the production of a range of inflammatory mediators (prostaglandins and cytokines), each with a specific role in the inflammatory process, including fighting pathogens, tissue destruction, altering blood vessel permeability, chemotaxis (attracting other cells) and vasodilation (widening blood vessels).  Symptoms of inflammation are effectively side effects of the body’s natural processes and include redness, swelling, pain and fever.  Inflammation is a symptom of many chronic disorders like arthritis, and if inflammation becomes chronic it thought to trigger many other diseases.\r \u003c\/p\u003e\r \u003ch4\u003e\r What is a diuretic?\u003c\/h4\u003e\r \u003cp\u003e\r A diuretic is a substance that promotes the removal of water and salts from the body and increases urine production.\r \u003c\/p\u003e\r \u003ch3\u003e\r What are the Ingredients of Arthro Ease Oral Liquid?\u003c\/h3\u003e\r \u003ch4\u003eKey Ingredients:\u003c\/h4\u003e\r \u003ch4\u003e\u003c\/h4\u003e\r \u003ch5\u003eBirch Leaf \u003cem\u003e(Betula pendula):\u003c\/em\u003e\n\u003c\/h5\u003e\r \u003cp\u003e\r Silver birch is a tree native to Europe and Asia and Birch Leaf has long been used in traditional\r medicine of Eastern Europe for its diuretic and anti-inflammatory properties, particularly for cystitis.  Recent studies have shown that extract of Birch Leaf inhibits the activity of the enzyme xanthine oxidase, which is responsible for causing a build-up of crystals of uric acid in the blood and can lead to gout and kidney stones.  Endopeptidase is an enzyme found in extract of Birch Leaf that breaks down proteins and also influences blood pressure and kidney function and is thought to contribute to the diuretic properties of Birch Leaf\u003csup\u003e1, 2.\u003c\/sup\u003e  Birch Leaf also contain high levels of phenolic compounds which are thought to contribute to its antioxidant properties and is also rich in minerals and other nutrients\u003csup\u003e3, 4.  \u003c\/sup\u003e\u003c\/p\u003e\r \u003ch5\u003e\r Dandelion root\u003cem\u003e (Taraxacum officinale): \u003c\/em\u003e\n\u003c\/h5\u003e\r \u003cp\u003e\r Dandelion is a flowering plant belonging to the Asteraceae or Compositae (Sunflower) family that is native to Europe but now grows ubiquitously as a wild flower.  The Dandelion plant was used in traditional medicine in several ancient cultures for digestive and liver disorders as a bitter digestive stimulant and as a diuretic.  It is now used to treat several ailments including dyspepsia and liver complaints\u003csup\u003e5,6.\u003c\/sup\u003e  Dandelion root contains several bioactive compounds including vitamins, minerals, and sesquiterpene lactones, which gives Dandelion its bitter taste; also flavonoids, which are potent antioxidants, and may contribute to its biological activities7.  Clinical and pre-clinical studies support the use of Dandelion extract as a diuretic to increase urine output\u003csup\u003e6, 7.\r \u003c\/sup\u003e\u003c\/p\u003e\r \u003ch5\u003e\r Meadowsweet \u003cem\u003e(Filipendula ulmaria):\u003c\/em\u003e\n\u003c\/h5\u003e\r \u003cp\u003e\r Meadowsweet is a perennial herb belonging to the Rosaceae (Rose) family and grows in damp meadows throughout Europe and Asia.  In traditional herbal medicine Meadowsweet was used to treat gout, urinary stones, rheumatism, liver disorders, flatulence and bad breath, due to its antirheumatic, antipyretic, diuretic properties.  In contemporary herbal medicine, Meadowsweet is used as a remedy for indigestion and peptic ulcers, and to relieve joint pain in rheumatoid and osteoarthritis.  Animal studies and studies in vitro have supported its anti-inflammatory and gastroprotective properties and the combination of salicylic acid, heparin, tannins and polyphenol in extracts of Meadowsweet are thought to contribute to its bioactive properties\u003csup\u003e8, 9, 10.  \u003c\/sup\u003e\u003c\/p\u003e\r \u003ch5\u003e\r Nettle\u003cem\u003e (Urtica dioica):\u003c\/em\u003e\n\u003c\/h5\u003e\r \u003cp\u003e\r Nettle, also known as the stinging nettle, is a perennial flowering plant belonging to the Urticaceae family.  It has been used in traditional medicine to treat many ailments including rheumatism, gout and kidney stones and is considered an important cleansing herb.  The leaves are rich in vitamins, minerals and other nutrients; also many bioactive compounds and they also have healing and antioxidant properties11, 12. Animal studies have demonstrated that extract of Nettle has diuretic properties and increases the excretion of sodium by the kidneys\u003csup\u003e13. \u003c\/sup\u003e There is some in vitro evidence to suggest that extract of nettle may be protective of cartilage degradation and may be an effective remedy for arthritis\u003csup\u003e14, 15, 16, \u003c\/sup\u003e\u003c\/p\u003e\r \u003ch5\u003e\r Willow bark \u003cem\u003e(Salix sp):\u003c\/em\u003e\n\u003c\/h5\u003e\r \u003cp\u003e\r The Willow tree belongs to the (Salicaceae) family and traditionally, and willow bark has been used as a natural anti-inflammatory, analgesic and antipyretic (fever reducing) for many thousands of years and in many ancient civilisations throughout our history, as far back as the Egyptians and in ancient Greece.  In 1763 Willow bark was first used as an effective treatment for fever and then in 1826 salicin was first identified in a Willow bark extract as the active ingredient that gave willow bark its anti-inflammatory, analgesic and antipyretic properties.  Further studies on the extraction, purification and processing of salicin led to the development of one of the most widely used drugs of our era; salicylic acid or aspirin.  Decades of experimental studies and clinical trials led to an understanding of the biochemistry and medical implications of aspirin as an inhibitor of the cyclooxygenase enzyme, that initiates a cascade for the production of inflammatory mediators, and it is now also widely used to reduce risk of cardiovascular disease due to its anti-platelet properties\u003csup\u003e17, 18.\u003c\/sup\u003e  Although salicin is the main active ingredient in Willow Bark other ingredients in extracts of Willow Bark may contribute to its therapeutic properties such as polyphenols and flavonoids, which may be helpful for reducing pain and improving mobility in arthritis and back pain\u003csup\u003e19.\u003c\/sup\u003e  Clinical studies in patients with osteoarthritis and rheumatoid arthritis suggested that Willow bark extract was moderately effective in reducing pain and was well tolerated\u003csup\u003e20, 21, 23, 23.  \u003c\/sup\u003e\u003c\/p\u003e\r \u003ch4\u003e\r Other ingredients\u003c\/h4\u003e\r \u003cp\u003e\r Herbal extracts are in a natural vegetable glycerin base that contains ethanol, peppermint and ginger.\r \u003c\/p\u003e\r \u003ch3\u003e\r What are the Contraindications\/Interactions of Arthro Ease Oral Liquid?\u003c\/h3\u003e\r \u003ch4\u003e\u003cstrong\u003e\r \u003ch5\u003e\r Use with caution if you: \u003c\/h5\u003e\r \u003c\/strong\u003e\u003c\/h4\u003e\r \u003cul\u003e\r     \u003cli\u003eare pregnant, without discussion with your doctor\u003c\/li\u003e\r     \u003cli\u003eare asthmatic as willow bark and meadowsweet can make your asthma worse\u003c\/li\u003e\r     \u003cli\u003eare allergic to aspirin as willow bark and meadowsweet contain aspirin-like chemicals\u003c\/li\u003e\r     \u003cli\u003ehave a bleeding disorder as willow bark and meadowsweet contain natural chemicals that can increase bleeding \u003c\/li\u003e\r     \u003cli\u003eare taking blood thinning medications or medication for diabetes, heart conditions, as nettle may case interact with these medications\u003c\/li\u003e\r     \u003cli\u003eare taking aspirin as this may increase risk of bleeding \u003c\/li\u003e\r \u003c\/ul\u003e\r \u003cp\u003e\r There are no documented herb-drug interactions within the recommended dosage.  However, you should always check the ingredients for known allergies and to ensure you do not have any allergies or sensitivities to these ingredients.  Stop using if you develop any irritation or allergy while taking Arthro Ease Oral Liquid.  Always read the label and use as directed or seek advice from your healthcare professional.\r \u003c\/p\u003e\r \u003ch3\u003e\r What are the Directions for using Arthro Ease Oral Liquid?\u003c\/h3\u003e\r \u003ch4\u003e\r Dosage:\u003c\/h4\u003e\r \u003ch4\u003e\u003cstrong\u003e\r \u003ch5\u003e\r For acute (short-term) use:\u003c\/h5\u003e\r \u003c\/strong\u003e\u003c\/h4\u003e\r \u003cp\u003e\r Use up to four times daily for one to two weeks.\r \u003c\/p\u003e\r \u003cul\u003e\r     \u003cli\u003eAdults: Take 10mls\u003c\/li\u003e\r     \u003cli\u003eChildren (6-12 years): Take 5mls\u003c\/li\u003e\r     \u003cli\u003eChildren  (2-5 years): Take 2.5mls\u003c\/li\u003e\r \u003c\/ul\u003e\r \u003ch4\u003e\u003cstrong\u003e\r \u003ch5\u003e\r For long-term use for prevention and upkeep:\u003c\/h5\u003e\r \u003c\/strong\u003e\u003c\/h4\u003e\r \u003cp\u003e\r Use once daily\r \u003c\/p\u003e\r \u003cul\u003e\r     \u003cli\u003eAdults: Take 5mls\u003c\/li\u003e\r     \u003cli\u003eChildren (6-12 years): Take 2.5mls\u003c\/li\u003e\r     \u003cli\u003eChildren (2-5 years): Take 1.5mls\u003c\/li\u003e\r \u003c\/ul\u003e\r \u003ch4\u003e\u003cstrong\u003e\r \u003ch5\u003e\r For best results:\u003c\/h5\u003e\r \u003c\/strong\u003e\u003c\/h4\u003e\r \u003cp\u003e\r Take the recommended dose for a minimum of 6 weeks and support with a low purine diet.\r \u003c\/p\u003e\r \u003ch4\u003e\r Special instructions\u003c\/h4\u003e\r \u003cp\u003e\r Shake well before use.\r Store out of direct sunlight and in a cool place.\r \u003c\/p\u003e\r \u003ch3\u003e\r Product Size:\u003c\/h3\u003e\r \u003cp\u003e\r 200ml\u003c\/p\u003e\r \u003ch3\u003e\r References\u003c\/h3\u003e\r \u003ch5\u003e\r The following references provide scientific support for the use of this product:\r \u003c\/h5\u003e\r \u003col\u003e\r     \u003cli\u003eHavlik J, Gonzalez de la Huebra R, Hejtmankova K, Fernandez J, Simonova J, Melich M, Rada V. Xanthine oxidase inhibitory properties of Czech medicinal plants.  Journal of Ethnopharmacology, vol. 132, no. 2, pp. 461–465, 2010.\u003c\/li\u003e\r     \u003cli\u003eGründemann C, Gruber CW, Hertrampf A, Zehl M, Kopp B, Huber R.  An aqueous birch leaf extract of Betula pendula inhibits the growth and cell division of inflammatory Lymphocytes.  Journal of Ethnopharmacology, vol. 136, no. 3, pp. 444-451, 2011.\u003c\/li\u003e\r     \u003cli\u003eBljaji K,  Šoštari N, Petlevski R, Vuji L,  Brajkov iA et al. Effect of Betula pendula Leaf Extract on 𝛼-Glucosidase and Glutathione Level in Glucose-Induced Oxidative Stress. Evidence-Based Complementary and Alternative Medicine 2016, Article ID 8429398, 8 pages. \u003c\/li\u003e\r     \u003cli\u003eRaudonė L, Raudonis R, Janulis V, Viškelis P.  Quality evaluation of different preparations of dry extracts of birch (Betula pendula Roth) leaves. Nat Prod Res. 2014;28(19):1645-8.\u003c\/li\u003e\r     \u003cli\u003eMir MA Sawhney SS, Jassal MMS. Qualitative and quantitative analysis of phytochemicals of Taraxacum officinale.  Wudpecker Journal of Pharmacy and Pharmocology Vol. 2(1), pp. 001 - 005, January 2013 \u003c\/li\u003e\r     \u003cli\u003eSchütz K, Carle R, Schieber A. Taraxacum--a review on its phytochemical and pharmacological profile. J Ethnopharmacol 2006 Oct 11;107(3):313-23.\u003c\/li\u003e\r     \u003cli\u003eGonzález-Castejón M, Visioli F, Rodriguez-Casado A. Diverse biological activities of dandelion. Nutr Rev. 2012 Sep;70(9):534-47. Clare BA, Conroy RS, Spelman K.  The diuretic effect in human subjects of an extract of Taraxacum officinale folium over a single day. J Altern Complement Med 2009 Aug;15(8):929-34. \u003c\/li\u003e\r     \u003cli\u003eSamardžić S, Arsenijević J, Božić D, Milenković M, Tešević V, Maksimović Z.  Antioxidant, anti-inflammatory and gastroprotective activity of Filipendula ulmaria (L.) Maxim. And Filipendula vulgaris Moench. J Ethnopharmacol. 2018 Mar 1;213:132-137. \u003c\/li\u003e\r     \u003cli\u003eKatanić J, Boroja T, Mihailović V, Nikles S, Pan SP, et al. In vitro and in vivo assessment of meadowsweet (Filipendula ulmaria) as anti-inflammatory agent. J Ethnopharmacol.2016 Dec 4;193:627-636. \u003c\/li\u003e\r     \u003cli\u003eDrummond EM, Harbourne N, Marete E, Martyn D, Jacquier J, O'Riordan D, Gibney ER.  Inhibition of proinflammatory biomarkers in THP1 macrophages by polyphenols derived from chamomile, meadowsweet and willow bark. Phytother Res.2013 Apr;27(4):588-94. \u003c\/li\u003e\r     \u003cli\u003eUpton R Stinging nettles leaf (Urtica dioica L): Extraordinary vegetable medicine.  Journal of Herbal Medicine 2013; 3, 1, 9-38 \u003c\/li\u003e\r     \u003cli\u003eJoshi BC, Mukhija M, Kalia AN. Pharmacognostical review of Urtica dioica L.  International Journal of Green Pharmacy. October 2014.\u003c\/li\u003e\r     \u003cli\u003eTahri A, Yamani S, Legssyer A, Aziz M, Mekhfi H, Bnouham M, Ziyyat A.  Acute diuretic, natriuretic and hypotensive effects of a continuous perfusion of aqueous extract of Urtica dioica in the rat. J Ethnopharmacol 2000 Nov;73(1-2):95-100. \u003c\/li\u003e\r     \u003cli\u003eSchulze-Tanzil G, de SP, Behnke B, Klingelhoefer S, Scheid A, Shakibaei M.  Effects of the antirheumatic remedy hox alpha--a new stinging nettle leaf extract--on matrix metalloproteinases in human chondrocytes in vitro. Histol Histopathol. 2002 Apr;17(2):477-85. \u003c\/li\u003e\r     \u003cli\u003eRiehemann K, Behnkec B, Schulze-Ostho¡a K, Plant extracts from stinging nettle (Urtica dioica), an antirheumatic remedy, inhibit the proin£ammatory transcription factor NF-UB. FEBS Letters 442 (1999) 89^94\u003c\/li\u003e\r     \u003cli\u003eShakibaei M, Allaway D, Nebrich S, Mobasheri A.Botanical Extracts from Rosehip (Rosa canina), Willow Bark (Salix alba), and Nettle Leaf (Urtica dioica) Suppress IL-1β-Induced NF-κB Activation in Canine Articular Chondrocytes Mehdi. Evidence-Based Complementary and Alternative Medicine Volume 2012, Article ID 509383, 16 pages\u003c\/li\u003e\r     \u003cli\u003eDesborough MJR, Keeling DM. The aspirin story – from willow to wonder drug.  British Journal of Haematology, 2017, 177, 674–683\u003c\/li\u003e\r     \u003cli\u003eWood JN.  From plant extract to molecular panacea: a commentary on Stone (1763) 'An account of the success of the bark of the willow in the cure of the agues'. Philos Trans R Soc Lond B Biol Sci 2015 Apr 19;370(1666). \u003c\/li\u003e\r     \u003cli\u003eShara M, Stohs SJ.  Efficacy and Safety of White Willow Bark (Salix alba) Extracts. Phytother Res.2015 Aug;29(8):1112-6. \u003c\/li\u003e\r     \u003cli\u003eNieman DC, Shanely RA, Luo B, Dew D, Mary Pat Meaney MP, Sha W. A commercialized dietary supplement alleviates joint pain in community adults: a double-blind, placebo-controlled community trial Nutr J 2013; 12: 154.\u003c\/li\u003e\r     \u003cli\u003eBeer AM, Wegener T. Willow bark extract (Salicis cortex) for gonarthrosis and coxarthrosis--results of a cohort study with a control group. Phytomedicine 2008 Nov;15(11):907-13.\u003c\/li\u003e\r     \u003cli\u003eSchmid B, Ludtke R, Selbmann HK, Kotter I, Tschirdewahn B, Schaffner W et al. Efficacy and tolerability of a standardized willow bark extract in participants with osteoarthritis: randomised placebo-controlled, double blind clinical trial. Phytotherapy Research 2001; 15(4):344–50. \u003c\/li\u003e\r     \u003cli\u003eBiegert C, Wagner I, Ludtke R, Kotter I, Lohmuller C, Gunaydin I et al. Efficacy and safety of willow bark extract in the treatment of osteoarthritis and rheumatoid arthritis: results of 2 randomised double-blind controlled trials. Journal of Rheumatology 2004; 31(11):2121–30. \u003c\/li\u003e\r \u003c\/ol\u003e","brand":"Artemis","offers":[{"title":"200ml","offer_id":31177949380653,"sku":"00161-200ml","price":39.04,"currency_code":"NZD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0268\/9954\/6157\/products\/1800002.jpg?v=1573461959","url":"https:\/\/nz-nutristrong.myshopify.com\/products\/artemis-arthro-ease-oral-liquid-200ml","provider":"NZ NutriStrong","version":"1.0","type":"link"}