Artemis Deep Sleep Tea | 30g

Artemis Deep Sleep Tea 

What is Deep Sleep Tea?

Insomnia or some form of disruption to normal sleep patterns affects the everyday life for many people. Deep Sleep Tea contains a range of natural herbal ingredients with relaxing calming properties that offers effective sleep support to help those who suffer from insomnia to overcome sleep problems and wake refreshed and recharged for the day ahead.

Why use  Deep Sleep Tea?

Sleep is as important as food and water to our health and well-being and ultimately to our survival; it is a time when our body restores vital processes and lack of quality sleep can have serious effects on our ability to function in everyday life, as well as impacting on our health and overall quality of life. Insomnia or some form of disruption to normal sleep patterns affects the everyday life for many people. Deep Sleep Tea contains a range of natural herbal ingredients, some of which have been used in traditional medicine for thousands of years, with relaxing calming properties that. The combination of herbal ingredients in Deep Sleep Tea helps you get a good night’s sleep and can provide effective sleep support to help those who suffer from insomnia, to overcome sleep problems and wake refreshed and recharged for the day ahead.

What are the Key Benefits of Deep Sleep Tea?

• Traditional medicinal plant formula 
• Provides natural sleep support
• Helps induce a feeling of calm and relaxation while reducing anxiety 
• All ingredients are certified organic, GE free and vegan
• Does not contain sugar or artificial sweeteners
• Does not contain added colours, flavours, preservatives, gluten, wheat or dairy

What is insomnia?

A sleep disorder is any disturbance in your normal pattern sleep that leaves you unrefreshed in the morning and affects your ability to function. Insomnia is a sleep disorder that can be short term or long term and is characterised by difficulty falling asleep, staying asleep, waking in the night, waking too early and not being able to go back to sleep, or a combination of all these.

What is an anxiolytic?

An anxiolytic is a substance that can relieve anxiety, aid sleep, or have a calming effect. Anxiety is a factor is sleep disruption and if reduced this can help restore quality sleep patterns.

What are the ingredients of Deep Sleep Tea?

Herbal mixtures have traditionally been used to aid sleep and reduce anxiety for thousands of years in many cultures around the world. The most commonly used plants for sleep include hops, lemon balm, valerian and passionflower. As the understanding about how they work has grown, the use of these herbs as nutritional support for metabolic pathways involved in sleep regulation is also increasing. Common mechanisms of action have been found for several of the plants studied and many involve the gamma-aminobutyric acid (GABA) pathway, which is the major inhibitory neurotransmitter in the central nervous system^1.

Key Ingredients:

Hops (Humulus lupulus):

Humulus lupulus is a flowering plant belonging to the Cannabaceae family, found throughout Europe and western Asia. Hops are known for their soothing, calming and sedative properties and have long been used in traditional medicine to help with sleep disturbances. These properties have been supported by clinical studies, particularly when combined with other herbs like Valerian^{2, 3, 4.} Several active ingredients have been identified that are responsible for the neuropharmacological effects of hops, including flavonoids and volatile oils5. Studies indicate that hop extract contains chemicals that bind to specific receptors for melatonin and serotonin that are involved in circadian rhythm and sleep regulation.

Valerian (Valeriana officinalis):

Valeriana officinalis is a flowering plant native to Europe and Asia. The roots of the Valerian plant have long been used in traditional medicine for relaxation and as a sedative. Valerian is used today to help with sleep problems and its usefulness is supported by clinical studies^7, particularly when combined with Hops^{2, 3.} Laboratory studies have suggested that Valerian is an anxiolytic and that valerenic acid, which is the active ingredient in Valerian extract, works by binding to a specific receptor in the brain for GABA^{8. I}n a study comparing the efficacy of a polyherbal combination of Valerian, Hops (see above) and Passiflora (see below) with zolpidem a sedative drug, found the herbal extract to be an effective alternative to medication for insomnia^9. A study using a Valerian and Hops combination compared with diphenhydramine, an antihistamine that is used for insomnia, also supported the possible use of this herbal combination for improving sleep^10.

Lemon Balm (Melissa officinalis):

Melissa officinalis is a flowering plant belonging to the mint family that is native to large areas of Europe and Asia and used in traditional medicine for it calming and relaxing properties. It is used today as a herbal supplement for insomnia and for its effect on mood, cognitive function and anxiety^{11, 12}. A study in volunteers with mild-to-moderate anxiety disorders and sleep disturbances demonstrated a significant improvement in symptoms with an extract of lemon balm by reducing worry and stress that can disrupt normal sleep and it is suggested that this may be an alternative to prescription medication^13. A study in healthy volunteers found a combination extract of Lemon balm and Valerian reduced laboratory induced stress^14. Extracts of Lemon Balm contain several bioactive components and laboratory studies have demonstrated that it binds to several brain receptors, including the GABA receptor. It is thought that the anxiolytic effect and calming effect of Lemon Balm is based on binding to one or more of these receptors that modulate mood^{11, 12.}

Licorice (Glycyrrhiza glabra):

Glycyrrhiza glabra is a perennial plant belonging to the legume family (pea and bean) and is native to Southern Europe and India. Its roots contain the sweet flavour known as licorice that has been used as a botanical drug in several ancient cultures^15. It was used in traditional oriental medicine to replenish and invigorate and in other cultures to treat several ailments including peptic ulcers, liver diseases like hepatitis C, lung diseases and skin conditions. Licorice has several active ingredient, the main one being glycyrrhizin, a triterpenoid saponin. The pharmacological effects of glycyrrhizin have been extensively studied and include anti-inflammatory, anti-viral, antimicrobial, immunomodulatory antioxidative as well as cancer and liver protecting effects^{16, 17.} Licorice has also been found to have neuropharmacological properties such as neuroprotective, antidepressant, and anxiolytic effects, which are thought to be mediated by interacting with receptors in the brain, particularly of the GABA and dopamine system. Glycyrrhizin is an adaptogen, which is a plant that helps the body cope better with stress, and works by modulating the production of the stress hormone cortisol. Glycyrrhizin inhibits 11 beta-hydroxysteroid dehydrogenase, the enzyme responsible for inactivating cortisol^{19, 20;} reducing stress levels helps with sleep problems.

Passionflower (Passiflora incarnata):

Passiflora incarnate is a perennial vine and its many species are found mainly in Central and South America. The flower has been used as a traditional herbal sedative anxiolytic and to help with sleep disturbance. Several preclinical experiments demonstrated pharmacological activities of Passionflower extract, and these include anxiolytic and sedative properties, which have been supported in some clinical studies²¹. A placebo controlled study has demonstrated that a tea containing a low dose of Passiflora incarnate improves sleep in for healthy adults with mild fluctuations in sleep quality^22. The pharmacological effects of Passionflower were demonstrated in laboratory experiments to be mediated by modulation of the GABA system^23.

Woodruff (Galium odoratum):

Galium odoratum, a flowering plant belonging to the Rubiaceae family, commonly known as sweet woodruff, is found in Northern and Central Europe, Siberia, Northern Africa and Iran. Due to its aromatic fragrance Woodruff is used as a room freshener and for flavouring. The leaves were used in herbal medicine during the Middle Ages for wound healing and an infusion is used today as a relaxation tea and to help with insomnia and nervous tension. There are several active ingredients that contribute to its bioactive properties of Woodruff including coumarin an anticoagulant and antioxidants^24.

What are the Contraindications/Interactions of Deep Sleep Tea?

There are no documented herb-drug interactions within the recommended dosage. However, you should always check the ingredients for known allergies and to ensure you do not have any allergies or sensitivities to these ingredients. Stop using if you develop any irritation or allergy while taking Deep Sleep Tea. Always read the label and use as directed or seek advice from your healthcare professional.

Caution:

Deep Sleep Tea should be used with caution when:

• taking sedative medications as several ingredients also have sedative properties
• taking therapy for thyroid problems as Lemon balm may interfere with thyroid therapy
• taking blood pressure lowering medications as Passion flower may lower blood pressure
• if pregnant or while breast-feeding

What is the Dosage Recommendation for Deep Sleep Tea?

Adults:

150ml  1-2x at night

Children (6-12 years):

60-100ml, 1-2x at night

Children (1-6 years):

20-60ml, 1-2x at night

Infants (6-12 mths): 

10ml, 1-2x at night 

Babies (0-6mths):

5ml, 1-2x when needed

For best results:

Shake the can before opening, as the contents may settle.

Special instructions

• For children, make the full adult dose (1g/cup) and then measure the required volume.
• Do not microwave. 
• Close can immediately after use to avoid external contamination. 
• Store in the fridge in hot and humid climates and keep away from heat and moisture. 

Product Size:

30g

References

The following references provide scientific support for the use of this product:

1. Sarris J, McIntyre E, Camfield DA. Plant-based medicines for anxiety disorders, Part 1: a review of preclinical studies. CNS Drugs 2013 Mar;27(3):207-19.
2. Salter S, Brownie S. Treating primary insomnia - the efficacy of valerian and hops. Aust Fam Physician 2010 Jun;39(6):433-7.
3. Palmieri G, Contaldi P, Fogliame G. Evaluation of effectiveness and safety of a herbal compound in primary insomnia symptoms and sleep disturbances not related to medical or psychiatric causes. Nature and Science of Sleep 2017 9 163–169.
4. Schiller H, Forster A, Vonhoff C, Hegger M, Biller A, Winterhoff H. Sedating effects of Humulus lupulus L. extracts. Phytomedicine.2006 Sep;13(8):535-41. 
5. Zanoli P, Zavatti M. Pharmacognostic and pharmacological profile of Humulus lupulus L. J Ethnopharmacol 2008 Mar 28;116(3):383-96. 
6. Abourashed EA, Koetter U, Brattström A. In vitro binding experiments with a valerian, hops and their fixed combination extract (ze91019) to selected central nervous system receptors. Phytomedicine. 2004;11(7–8):633–638.
7. Fernández-San-Martín MI, Masa-Font R, Palacios-Soler L, Sancho-Gómez P, Calbó-Caldentey C, Flores-Mateo G. Effectiveness of Valerian on insomnia: a meta-analysis of randomized placebo-controlled trials. Sleep Med 2010 Jun;11(6):505-11. 
8. Becker A, Felgentreff F, Schröder H, Meier B, Brattström A. The anxiolytic effects of a Valerian extract is based on Valerenic acid. BMC Complementary and Alternative Medicine 2014, 14:267
9. Maroo N, Hazra A, Das T. Efficacy and safety of a polyherbal sedative-hypnotic formulation NSF-3 in primary insomnia in comparison to zolpidem: a randomized controlled trial. Indian J Pharmacol 2013 Jan-Feb;45(1):34-9. 
10. Morin CM, Koetter U, Bastien C, Ware JC, Wooten V. Valerian-hops combination and diphenhydramine for treating insomnia: a randomized placebo-controlled clinical trial. Sleep. 2005;28(11):1465–1471.
11. Scholey A, Gibbs A, Neale C, Perry N, et al. Anti-stress effects of lemon balm-containing foods. Nutrients. 2014 Oct 30;6(11):4805-21. 
12. Shakeri A, Sahebkar A, Javadi B. Melissa officinalis L. - A review of its traditional uses, phytochemistry and pharmacology. J Ethnopharmacol 2016 Jul 21;188:204-28. 
13. Cases J, Ibarra A, Feuillère N, Roller M, Sukkar SG. Pilot trial of Melissa officinalis L. leaf extract in the treatment of volunteers suffering from mild-to-moderate anxiety disorders and sleep disturbances. Med J Nutrition Metab 2011 Dec;4(3):211-218. 
14. Kennedy DO, Little W, Haskell CF, Scholey AB. Anxiolytic effects of a combination of Melissa officinalis and Valeriana officinalis during laboratory induced stress. Phytother Res 2006 Feb;20(2):96-102.
15. Fiore C, Eisenhut M, Ragazzi E, Zanchin G, Armanini D. A history of the therapeutic use of liquorice in Europe. J Ethnopharmacol. 2005 Jul 14;99(3):317-24.
16. Asl MN, Hosseinzadeh H. Review of pharmacological effects of Glycyrrhiza sp. and its bioactive compounds. Phytother Res 2008 Jun;22(6):709-24. 
17. Shamsa F, Ohtsuki K, Hasanzadeh E, Rezazadeh S. The Anti-inflammatory and Anti-viral Effects of an Ethnic Medicine: Glycyrrhizin. J Medicinal Plants Volume 9, Supplement No. 6, 2010
18. Zhao ZL, Kim SC, Liu HF, Wu YY, Li LB et al. Blockade of nicotine sensitization by methanol extracts of Glycyrrhizae radix mediated via antagonism of accumbal oxidative stress. BMC Complement Altern Med 2017 Nov 16;17(1):493. 
19. Isbrucker RA, Burdock GA. Risk and safety assessment on the consumption of Licorice root (Glycyrrhiza sp.), its extract and powder as a food ingredient, with emphasis on the pharmacology and toxicology of glycyrrhizin. Regul Toxicol Pharmacol 2006 Dec;46(3):167-92. 
20. Al-Dujaili EA, Kenyon CJ, Nicol MR, Mason JI. Liquorice and glycyrrhetinic acid increase DHEA and deoxycorticosterone levels in vivo and in vitro by inhibiting adrenal SULT2A1 activity. Mol Cell Endocrinol 2011 Apr 10;336(1-2):102-9. 
21. Miroddi M, Calapai G, Navarra M, Minciullo PL, Gangemi S. Passiflora incarnata L.: ethnopharmacology, clinical application, safety and evaluation of clinical trials. J Ethnopharmacol 2013 Dec 12;150(3):791-804. 
22. Ngan A, Conduit R. A double-blind, placebo-controlled investigation of the effects of Passiflora incarnata (passionflower) herbal tea on subjective sleep quality. Phytother Res 2011 Aug;25(8):1153-9. 
23. Appel K, Rose T, Fiebich B, Kammler T, Hoffmann C, Weiss G. Modulation of the γ-aminobutyric acid (GABA) system by Passiflora incarnata L. Phytother Res. 2011 Jun;25(6):838-43. 
24. Kahkeshani N, Farahanikia B, Mahdaviani P, Abdolghaffari A, Hassanzadeh G, Abdollahi M, Khanavi M. Antioxidant and burn healing potential of Galium odoratum extracts. Res Pharm Sci. 2013 Jul;8(3):197-203.