Go Healthy Go Turmeric Sport Active | 30 VegeCapsules

Go Healthy Go Turmeric Sport Active

What is Go Turmeric Sport Active?

Go Turmeric Sport Active is a combination of high strength turmeric, and a selected blend of natural herbs and nutrients, with properties that promote joint health and mobility, support heart health and also support energy and recovery for those who are active.

Why use Go Turmeric Sport Active?

Activity and strenuous exercise can cause depletion of energy stores and vital nutrients and can even stress and damage body tissues if taken to excess. Go Turmeric Sport Active is a combination of high strength turmeric, and a selected blend of natural herbs and nutrients with properties that work in synergy to promote joint health and mobility, support heart health and also promote energy levels and muscle recovery for those who are active.

What are the Key Benefits of Go Turmeric Sport Active?

• Traditional medicinal plant formula 
• Supports joint health and mobility 
• Supports heart health
• Supports energy levels for intense activity
• Supports muscle relaxation and recovery 
• Fast acting formula with natural absorption enhancer
• VegeCapsules are all plant based
• Does not contain sugar or artificial sweeteners
• Does not contain added colours, flavours, preservatives, gluten, wheat or dairy

What are inflammatory mediators?

Inflammatory mediators are substances that promote inflammation by various mechanisms and are the target of anti-inflammatory herbs and medications.

Prostaglandins and leukotrienes

Prostaglandins and leukotrienes are eicosanoids that are synthesised from arachidonic acid, released from the cell membrane by the action of a phospholipase enzyme. Arachidonic acid then enters one of two biochemical pathways. Prostaglandins are produced by the action of the cyclooxygenase enzyme (COX), which exists in two forms. COX-1 is constitutively expressed by most cell types, which means it is always active and produces prostaglandins that carry out essential tasks like protecting gastric mucosa cells. COX-2 is an inducible enzyme, which means it is only produced during the inflammatory process and produces only inflammatory prostaglandins. The COX enzymes are the target of non-steroidal anti-inflammatory drugs (NSAIDs) and the more specific NSAIDs that are used for arthritis, target COX-2. Leukotrienes are inflammatory mediators produced by cells of the immune system. The arachidonic acid cleaved from the cell membrane enters a different pathway and is metabolised by the enzyme 5-lipoxygenase (5-LO) into leukotrienes.

Cytokines

Cytokines are small proteins produced by various cells including chondrocytes (cartilage cells) and synovial cells, which are cells of joint tissue; also cells immune system, and have specific effects including promoting the inflammatory process. They include the interleukins, particularly Interleukin-1 (IL-1) and Interleukin-6 (IL-6) and Tumour Necrosis Factor α (TNF α). These cytokines have destructive effects on joint tissues by increasing production of degradative enzymes such as metalloproteinases and collagenases. Inflammatory cytokines are induced during the inflammatory process by activation of inflammatory nuclear factor (NF-kB), a transcription factor that controls the expression of proinflammatory cytokine genes.

How is cellular energy generated?

Energy is derived from nutrients taken into the body as carbohydrates, fats and proteins, which store energy in their chemical bonds. These nutrients are broken into smaller components, such as fatty acids, amino acids and short chain carbohydrates and sugars, which are converted to energy by a process of oxidation, known as cellular respiration, that takes place in the mitochondria within cells of the body. This catabolic process creates the energy-rich but unstable molecule adenosine triphosphate (ATP), which releases energy when needed for anabolic reactions and for supplying energy to muscles. Metabolism is a sum of anabolic and catabolic processes. Another important molecule in energy generation is nicotinamide adenosine dinucleotide (NADH), which generates more ATP by glycolysis, oxidative phosphorylation and the citric acid cycle. Coenzyme Q10 is a naturally occurring compound found in the mitochondria that receives electrons from NADH, and this is an important stage of the electron transfer process of the oxidative respiratory chain in the generation of ATP.

What is oxidative stress and its relevance to exercise?

An antioxidant is a substance that that protects the body from damage due oxidative stress, caused by free radicles, which are oxygen molecules containing a single electron, making them highly reactive as they scavenge to find another unpaired electron. Free radicles are generated during normal metabolic and physiological process but also by external factors like smoking, alcohol and ultraviolet irradiation from the sun. Extreme prolonged and intense exercise can also generate free radicles in skeletal muscle, causing oxidative stress and resulting in muscle damage and fatigue, which may have a negative impact on muscle performance. Under normal conditions there is a balance between generation and elimination of free radicles due to the body’s antioxidant defence system, however, if more are generated than eliminated this causes oxidative stress which is damaging to the body^1.

What is bioavailability?

Bioavailability is an indication of the amount of a substance taken orally into the body that is absorbed, reaches the blood circulation and is distributed to the target tissue unchanged and in active form. Many drugs are metabolised by enzymes in the liver and intestinal wall and this reduces their bioavailability. Some herbal medicines like curcumin in Turmeric and boswellic acids in Boswellia, have low bioavailability as they are lipophilic (fat but not water soluble) and highly metabolised before reaching their targets. However, their bioavailability can be increased, for example by using delivery mechanisms like liposomes, taking together with a high fat meal, adding phosphatidylcholine (lecithin), which is a lipid and the main component of cell membranes, and including natural ingredients like piperine (see below).

What is synergy?

The concept of synergy applied to drugs or phytochemicals (natural plant compounds) is that two or more compounds have an effect that is greater than the effect of one of those compounds alone. Many phytochemicals have synergistic interactions due to complementary and overlapping mechanisms of actions and these can influence the effectiveness or bioavailability of the phytochemical^{2, 3, 4.} For example, boswellic acid found in Boswellia and curcumin found in turmeric have synergistic effects in reducing pain related symptoms of osteoarthritis^5. Combination of turmeric and Boswellia also reduces oxidative stress induced by intense exercise, in a synergistic manner, due to different mechanisms of action^6.

What is an adaptogen?

An adaptogen is a plant-derived substance that helps the body manage the physiological effects of stress and adapt to the changes experienced, without unwanted or toxic side effects.

What are the Ingredients of Go Turmeric Sport Active?

Go Turmeric Sport Active is a synergistic blend of selected herbal extracts, some of which have been used in traditional medicine for thousands of years, to support general health and wellbeing.

Each capsule of Go Turmeric Sport Active contains the following ingredients:

• Turmeric (Curcuma longa) 14,000mg 
• Boswellia (Boswellia sacra) 66.7mg
• Coenzyme Q10 30mg
• Magnesium amino acid chelate 400mg
• Arctic Root (Rhodiola rosea) 266mg
• Grape Seed (Vitis vinifera) 1000mg
• Black Pepper / BioPerine® 3mg (equivalent to 60mg black pepper fruit (Piper nigrum) and Piperine 2.85mg)

Turmeric (Curcuma longa):

Turmeric is a flowering plant belonging to the ginger family (Zingiberaceae) that is native to India and Southeast Asia. In traditional Indian (Ayurvedic) and Chinese medicine turmeric has been used for centuries for treating infections, dysentery, arthritis, fevers and digestive diseases. Turmeric has many biological effects including antioxidant, antimicrobial, anti-inflammatory, anticancer, wound healing and gastroprotective, and is used for treating and preventing various conditions including liver disease, diabetes, cardiovascular diseases, arthritis, urinary and gastrointestinal tract infections and gastric ulcers. The main pharmacologically active component in extract of turmeric rhizomes (horizontal underground stem) is the polyphenol curcumin that is also used as a spice and yellow pigment ^{7, 8, 9, 10.} Curcumin is known to be unstable, with poor absorption and low bioavailability and is rapidly metabolised. Since Curcumin has many well documented medicinal properties, several options for improving bioavailability have been investigated including the use of phytosomes, which is a complex of a natural ingredient like curcumin with a phospholipid usually phosphatidylcholine (lecithin)¹¹. Piperine, the major pharmacologically active component in both black and long pepper, has been shown to significantly increase bioavailability of curcumin^{12, 13.} The anti-inflammatory activity of curcumin has been studied in several experimental models and the mechanisms involved include inhibition of the COX enzyme, specifically COX-2 that is induced during the inflammatory response and produces inflammatory prostaglandins; Inhibition of production of the proinflammatory cytokines IL-1, IL-6 and TNF α from specific immune cells; and inhibiting the activation of inflammatory nuclear factor (NF-kB), a transcription factor that controls the expression of proinflammatory cytokine genes10, 14, 15. Curcumin extract was also found to inhibit joint destructive enzymes like collagenase and metalloproteinase in rheumatoid arthritis10, Acute muscle injury following intense exercise and sporting activity is the result of triggering the inflammatory response and generation of free radicles. Clinical studies have indicated that extract of turmeric reduces inflammation and oxidative stress in skeletal muscle and is effective in relieving musculoskeletal pain due to traumatic injury or physical overload, which may help reduce delayed onset muscle soreness and help promote muscle recovery following intense exercise or sporting activity^{15. 16, 17.} Clinical studies have demonstrated that various turmeric/curcumin extracts are effective in relieving symptoms of arthritis and are as effective as other supplements like chondroitin and glucosamine; also, traditional non-steroidal anti-inflammatory medications in reducing pain and inflammation, as well as improving joint mobility. Turmeric was also found to be safe, well tolerated and non-toxic, ^{14, 18, 19.} There is also clinical and preclinical evidence that turmeric has analgesic properties that can reduce the pain level in the osteoarthritic joints^20.

Coenzyme Q10

Coenzyme Q10 (also known as ubiquinone and ubidecarenone), is a naturally-occurring lipid-soluble coenzyme. It is synthesised in the liver and found in most cells of the body in the mitochondrial membranes, which is where energy is generated in the form of adenosine triphosphate (ATP), and is found in highest concentrations in tissues with high energy turnover such as the heart, brain, liver and kidney. Coenzyme Q10 works by acting as an electron and proton carrier in aerobic (oxidative) cellular respiration and is required for synthesis of ATP for generation of biological energy needed for normal cell function^21. It is also a powerful antioxidant and works by scavenging free radicals and protecting cell membranes from oxidative damage21. Oxidative stress and inflammation play a central role in the pathogenesis of several chronic diseases, which are also associated with a deficiency in Coenzyme Q10. These include cardiovascular disease, diabetes and some neurodegenerative disorders; also with male infertility. A deficiency in Coenzyme Q10 is also associated with the aging process, and some medications like statins for high cholesterol can also reduce levels of Coenzyme Q10. Review of many clinical studies has indicated that supplementation with Coenzyme Q10 may have health benefits including reducing cardiovascular events, improving symptoms of congestive heart failure, reducing high cholesterol, and enhancing health during aging^{21,22,23,24,25.} Coenzyme Q10 depletion has been demonstrated following intense exercise, which can be minimised by Coenzyme Q10 supplementation. Improved cellular bioenergetics (generation and use of energy for biological processes) and enhanced cellular and circulating antioxidants levels have also been demonstrated following Coenzyme Q10 supplementation. In some studies, Coenzyme Q10 supplementation was found to improve performance, extend the time to exhaustion and reduce fatigue in healthy volunteers and athletes^{26, 27, 28.}

Magnesium amino acid chelate

Magnesium is an essential mineral obtained from the diet and is involved in more than 300 metabolic reactions, which is why it is so important for many physiological processes, including maintaining normal nerve and muscle function, production of energy, control of blood pressure, normal heartbeat, maintenance of blood glucose levels, bone structure and strength (60% of total body magnesium stores are found in bone), DNA and RNA synthesis and the synthesis of the antioxidant glutathione^{29, 30.} Magnesium deficiency is common and related to several chronic and inflammatory diseases including high blood pressure, cardiovascular disease, type-2 diabetes, and mood disorders like anxiety and depression. Early symptoms of magnesium deficiency include loss of appetite, nausea, vomiting, fatigue, and weakness. Magnesium is involved in ion transport across cell membranes, which is vital for nerve transmission and muscle contraction. Magnesium also plays an important role in energy production and storage (generation of ATP by glycolysis and oxidative phosphorylation). Studies have indicated that many athletes do not consume adequate amounts of magnesium in their diets and that maintaining the recommended daily intake of dietary magnesium is important for physical activity and performance^31. Strenuous exercise can cause loss of magnesium due to increased excretion in sweat and urine, which may result in magnesium deficiency and could impact on exercise performance, as magnesium is essential for normal muscle function and glucose mobilisation as an energy source32. There is some clinical evidence that magnesium supplementation may improve exercise performance and promote muscle recovery^{33, 34.} As a supplement, magnesium is available in several forms, which vary in the rates of absorption. Magnesium amino acid chelate is an organic form of magnesium that is more easily absorbed and therefore, has greater bioavailability.

Arctic Root (Rhodiola rosea):

Arctic Root is a perennial flowering plant in the family Crassulaceae. It grows naturally in wild Arctic regions of Europe, Asia, and North America, and has long been used in traditional herbal medicine for reducing fatigue, stress and depression, stimulating the nervous system and enhancing work performance. Several preclinical and clinical studies have indicated that Artic root is an adaptogen with neuroprotective, cardioprotective, anti-fatigue, antidepressive and anxiolytic properties and can increase mental performance^35. Arctic Root extract contains several pharmacologically active components including rosavin a phenolic glycoside and salidroside a phenolic glucoside, both thought to be responsible for its biological activity, by stimulating several brain neurotransmitters and acting as a free radicle scavenger^{35, 36, 37, 38.} Some clinical evidence indicates that Arctic Root can help relieve muscle and joint paint due to intense exercise, although it is not clear whether Arctic Root is an ergogenic aid (performance enhancer) for physical and mental performance^{37, 39.}

Boswellia (Boswellia serrata):

Boswellia, also known as Indian frankincense, is a resin extracted from the bark of the Boswellia serrata tree belonging to the Burseraceae family that is native to India. In traditional Indian Ayurvedic medicine, Boswellia gum was used to treat several inflammatory diseases including inflammation of the skin, eye, gums, gastrointestinal tract and joints, as well as respiratory inflammatory disorders such as asthma. It is still used to treat chronic inflammatory diseases such as chronic ulcerative colitis, rheumatoid arthritis, Crohn's disease, and bronchial asthma^40. Boswellia resin has potent anti-inflammatory activity, as well as anti-arthritic and analgesic activity, due to the presence of boswellic acids, which are pentacyclic triterpenes, and the most active boswellic acid in terms of anti-inflammatory activity has been identified as acetyl-11-keto-beta-boswellic acid (AKBA)^{41, 42.} However, the boswellic acids have low bioavailability due to poor absorption from the intestines, which can be increased by various strategies, such as using a lecithin delivery system, formulating with phospholipids and taking with a high fat meal^{43, 44.} Based on in vitro and animal studies, the mechanism of action for the anti-inflammatory activity is thought to be primarily by blocking the production of proinflammatory leukotrienes by inhibition of 5-lipoxygenase (5-LO), the enzyme regulating leukotriene synthesis by specific cells of the immune system. Another anti-inflammatory mechanism identified is inhibition of the COX enzyme that produces inflammatory prostaglandins^40. Outcomes of several clinical studies have demonstrated that various extracts of Boswellia can improve pain, inflammation and joint mobility in osteoarthritis of the knee^{45, 46, 47, 48.} Boswellia also has powerful antioxidant and immunomodulatory properties that have been demonstrated in preclinical and clinical studies^{49, 50.} A combination of Boswellia with turmeric was found to have a beneficial effect in reducing oxidative stress in chronically exercising master athletes^6.

Grape Seed (Vitis vinifera):

The common Grape Vine is grown in many temperate regions and the fruit is eaten fresh or used to make wine. The seeds are rich in proanthocyanins, a flavonoid and one of the most potent natural antioxidants for removing free radicles that cause oxidative damage to cells. Proanthocyanins have many health benefits due to anti-inflammatory, antioxidant and anti-cancer properties, and a possible role in protecting against prostate cancer and cardiovascular diseases^{51, 52, 53.} Grape seed extract has also been found to provide protection from sun damage, improve joint flexibility and improve circulation^54.

Black pepper (Piper nigrum):

Black pepper is a flowering vine belonging to the Piperaceae family that is native to Southern India and grown for its fruit. The peppercorn is the dried fruit of the black pepper and is used as a spice in cooking and also in traditional herbal medicine particularly Ayurvedic (traditional Indian herbal medicine) for reducing inflammation, improving digestion, relieving pain and treating asthma. The major pharmacologically active component in black pepper is piperine, an alkaloid that gives pepper its pungent properties and has many bioactive properties including anti-inflammatory, by inhibiting production of inflammatory cytokines, antioxidant by acting as a free radicle scavenger, promoting digestion by stimulating pancreatic digestive enzymes and reducing the time food remains in the intestines, and inhibiting enzymes that metabolise drugs in the liver. Piperine also has anti-cancer and anti-ulcer properties^{55, 56, 57, 58.} Piperine is an effective bioavailability enhancer and is used to improve the bioavailability of several prescription drugs and phytochemicals^{59, 60.} Piperine has several mechanisms of action that enhance bioavailability. These include improving absorption from the intestines by stimulating transporter proteins and inhibiting elimination of the drug/phytochemical from cells, so that it is active for longer. Piperine also inhibits specific enzymes in the intestines and liver that metabolise drugs, particularly UDP-glucuronyl transferase and arylhydrocarbon hydroxylase; also, cytochrome P-450 isoforms, that are responsible for metabolism of drugs when they pass through the liver after absorption (first pass metabolism). This first pass metabolism results in loss of bioavailability of many drugs^{55, 57, 60.} Curcumin in Go Turmeric Sport Active has low bioavailability due to poor absorption from the intestines and metabolism in the liver. Piperine significantly increased the bioavailability of curcumin when given to rats and healthy human volunteers together with curcumin^{12, 13.}

What are the Contraindications/Interactions of Go Turmeric Sport Active?

You should always check the ingredients for known allergies and to ensure you do not have any allergies or sensitivities to these ingredients. Stop using if you develop any irritation or allergy while taking Go Turmeric Sport Active. Always read the label and use as directed or seek advice from your healthcare professional.

Caution:

If you are taking prescription medicines you should check with your doctor before using Go Turmeric Sport Active.

Do not use if:

• you are pregnant or while breast-feeding
• you are taking anticoagulants like warfarin or anti-platelet medication like clopidogrel or aspirin (blood-thinning medications) as turmeric can prolong bleeding

Side effects:

Coenzyme Q10 can cause mild gastrointestinal effects such as dyspepsia (indigestion), loose stool, diarrhoea nausea, vomiting. Turmeric can cause diarrhoea, nausea and flatulence.

What are the Directions for using Go Turmeric Sport Active?

Adults:

Take one VegeCapsule of Go Turmeric Sport Active once daily with food. The dose may be increased to two VegeCapsules daily for high intensity training, or as required.

References

The following references provide scientific support for the use of this product:

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53. Garavaglia J, Markoski MM, Aline Oliveira A, Marcadenti A. Grape Seed Oil Compounds: Biological and Chemical Actions for Health. Nutr Metab Insights2016; 9: 59–64.
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56. Hazra AK, Chakraborty B, Mitra A, Sur TK. A rapid HPTLC method to estimate piperine in Ayurvedic formulations containing plant ingredients of Piperaceae family. J Ayurveda Integr Med.2018 Oct 11. pii: S0975-9476(17)30214-0. 
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59. Mhaske DB , Sreedharan S, Mahadik KR. Role of piperine as a bioavailability enhancer. Pharm Anal Acta 2018, 9:7.
60. Han HK. The effects of black pepper on the intestinal absorption and hepatic metabolism of drugs. Expert Opin Drug Metab Toxicol.2011 Jun;7(6):721-9.