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Go Healthy Go Turmeric Digestion Eze

Go Healthy Go Turmeric Digestion Eze

$30.00
$30.00
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Go Healthy Go Turmeric Digestion Eze

What is Go Turmeric Digestion Eze?

Go Healthy Go Turmeric Digestion Eze 1-A-Day is a comprehensive formulation of Turmeric and Aloe Vera blended with key natural herbs, spices and nutrients with properties that support overall digestive function, liver health and wellness.

Why use Go Turmeric Digestion Eze?

A healthy digestive system and liver function are essential for general health and wellbeing. Indigestion and digestive discomfort after eating is an indication that all is not well. Go Turmeric Digestion Eze is a combination of natural herbs and spices to help settle, soothe and support digestion with properties that support digestive health and promote healthy liver function for overall health and wellness.

What are the Key Benefits of Go Turmeric Digestion Eze?

  • Traditional medicinal plant formula 
  • Promotes all round health and wellbeing
  • Supports digestive health
  • Helps relieve digestive discomfort after eating
  • VegeCapsules are all plant based
  • Does not contain sugar or artificial sweeteners
  • Does not contain added colours, flavours, preservatives, gluten, wheat or dairy

What is an antioxidant?

An antioxidant is a substance that that protects the body from damage due to oxidative stress, caused by free radicles, which are oxygen molecules containing a single electron, making them highly reactive as they scavenge to find another unpaired electron.

What is gastroprotective?

A gastroprotective substance, which includes many herbal medicines, is one that protects the gastric mucosa against damage caused by many factors, including toxins, alcohol consumption, use of non-steroidal anti-inflammatory drugs (NSAIDs), the presence of enteric (gut) pathogens, or an imbalance in the gut microbiota (bacteria that play an important role in gut health and digestion). Damage to the gastric mucosa can lead to gastrointestinal problems such as inflammatory bowel disease and ulcers1.

What is hepatoprotective?

A hepatoprotective substance, which includes plant based phytochemicals, is one that protects the liver against damage that may compromise its important functions including detoxifying harmful substance like medicinal drugs, alcohol and environmental toxins, secreting bile for digestion, synthesising cholesterol needed for many physiological processes, and regulating metabolism by storing and releasing glucose. Damage to the liver can result in diseases such as hepatitis (inflammation of the liver) and cirrhosis (damage to liver cells)2.

What is bioavailability?

Bioavailability is an indication of the amount of a substance taken orally into the body that reaches the blood circulation unchanged and in active form. Many drugs are metabolised by enzymes in the liver and intestinal wall and this reduces their bioavailability.

What are the Ingredients of Go Turmeric Digestion Eze?

Go Turmeric Digestion Eze blends a selection of herbal extracts, some of which have been used in traditional medicine for thousands of years to support general health and wellbeing.

Each capsule of Go Turmeric Digestion Eze contains the following ingredients:
  • Turmuric (Curcuma longa) 19,000mg 
  • Aloe vera (Aloe barbadensis) 10,000mg 
  • Chamomile (Matricaria chamomilla) 400mg 
  • Peppermint (Metha piperita) 200mg 
  • Bromelain 30mg 
  • Black Pepper / BioPerine® 6mg  (equivalent to 120mg black pepper fruit (Piper nigrum) and Piperine 5.7mg)
  • Long pepper (Piper longum) 120mg
  • Ginger (Zingiber officinale) 120mg
Turmeric (Curcuma longa):

Turmeric is a flowering plant belonging to the ginger family (Zingiberaceae) that is native to India and Southeast Asia. In traditional Indian (Ayurvedic) and Chinese medicine turmeric has been used for centuries for treating infections, dysentery, arthritis, fevers and digestive diseases. Turmeric has many biological effects including antioxidant, antimicrobial, anti-inflammatory, anticancer, wound healing and gastroprotective, and is used for treating and preventing various conditions including liver disease, diabetes, cardiovascular diseases, arthritis, urinary and gastrointestinal tract infections and gastric ulcers. The main pharmacologically active component in extract of Turmuric rhizomes (horizontal underground stem) is the polyphenol curcumin that is also used as a spice and yellow pigment3, 4, 5, 6. Curcumin has gastroprotective and antiulcerogenic effects, as demonstrated in animal and in vitro studies. Several possible mechanism of action for curcumin have been identified, including antioxidant activity, anti-inflammatory action and ability to inhibit gastric acid secretion; also antimicrobial activity against Helicobacter pylori, a bacteria linked to the pathogenesis of gastric ulcers, and to specific anti-inflammatory action, by blocking the production of anti-inflammatory mediators, including the specific enzyme (cyclooxygenase COX-2) that produces inflammatory prostaglandins without effecting the production of protective prostaglandins6, 7, 8. Animal and clinical studies have indicated that curcumin protects the gastric mucosa and helps protect and maintain the gut microbiota9. Experimental models of colitis have demonstrated the anti-inflammatory activity of curcumin in colonic tissue10, and clinical study of colitis have indicated that curcumin supplement prevents relapse from remission in patients with quiescent ulcerative colitis11. The cytoprotective effect of curcumin due to inhibition of inflammatory mediators and reducing oxidation stress causing cell damage, has been demonstrated in vitro and in animal and clinical studies12. Curcumin is known to be unstable, with poor absorption and low bioavailability and is rapidly metabolised. Since Curcumin has many well documented medicinal properties, several options for improving bioavailablitiy have been investigated including the use of natural compounds. Piperine, the major pharmacologically active component in both black and long pepper, has been shown to significantly increase bioavailability of curcumin13, 14.

Aloe Vera (Aloe barbadensis):

Aloe Vera is a succulent evergreen perennial plant belonging to the Asphodelaceae/Liliaceae family, native to Northern Africa, Southern Europe and the Canary Islands, but grown in many tropical and subtropical regions. Aloe Vera has been used in traditional medicine for thousands of years and as far back as ancient Egypt. Aloe Vera gel is rich in vitamins, minerals, natural sugars and bioactive compounds like acemannan polysaccharide and anthraquinones that contribute to its many properties and medicinal uses15. The gel extracted from the leaves of Aloe Vera has antibacterial, anti-inflammatory, antioxidant, wound healing, and immunomodulating properties and is used as a topical medication for treating skin conditions like acne, healing burns and minor cuts, and protecting skin from radiation damage. It is also used for digestive problems and as a laxative. Preclinical and clinical studies of the effect of Aloe Vera gel on inflammatory bowel disorders like ulcerative colitis, have indicated that Aloe Vera gel has potential as an alternative and complimentary treatment to relieve symptoms of these disorders due to its anti-inflammatory and immunomodulatory properties. The mechanism of action was found to be inhibition of inflammatory mediators and blocking recruitment of specific immune cells to the site of inflammation10, 16, 17. animal studies have indicated a protective role for Aloe Vera on the gastric mucosa, which helps prevent gastric ulcers, due to its anti-inflammatory, wound healing, cytoprotective and mucus stimulatory effects18, 19, 20. This gastroprotective effect is supported by clinical studies where Aloe vera extract was found to reduce symptoms of gastric reflux21 and promote healing of gastric ulcers22.

Chamomile (Matricaria chamomilla):

Chamomile is a flowering plant that belongs to the Asteraceae family and grows the world over. It has been used in traditional medicine by many cultures since ancient times for its calming and anti-inflammatory properties and to treat digestive ailments. Studies have identified many bioactive compounds in extracts of Chamomile including terpenoids, flavonoids and apigenin and Chamomile tea is used for its many medicinal properties, including mild sedation, helping with sleep problems, antispasmodic and digestive relaxant and wound healing. Chamomile tea is used to treat various gastrointestinal disorders and complaints including irritable bowel, inflammatory bowel, flatulence and heartburn; also colic and croup in children23, 24. The antiulcerogenic and antioxidative properties of Chamomile extract were demonstrated in animal models of induced ulcers and found to reduce lesions of the gastric mucosa due to gastric ulcers25. Hepatoprotective effects of Chamomile extract were demonstrated in animal models of induced liver damage and liver failure, as measured by several parameters including liver function enzymes, oxidative stress markers in the liver and histopathological features of liver cells2, 26.

Peppermint (Metha piperita):

Peppermint is a flowering plant native to Europe and the Middle East has been used in traditional herbal medicine for centuries for treating gastrointestinal ailments. It is well known for its soothing effect on the intestines to relieve digestive problems like gas, bloating, nausea and stomach cramps. Clinical and preclinical studies have demonstrated antispasmodic and relaxation effects on the intestine mediated by blocking calcium channels, as well as anti-inflammatory effects by inhibiting inflammatory mediators, and analgesic and anaesthetic effects by interacting with specific sensory receptors in the gut27, 28. Clinical studies have indicated that Peppermint oil is be effective in relieving symptoms of functional dyspepsia (indigestion)29, and irritable bowel syndrome30, 31, 32.

Bromelain:

Bromelain is a mixture of proteolytic enzymes derived from the pineapple plant (Ananas comosus) belonging to the Bromeliaceae family that is native to South America and has long been used in traditional medicine. Bromelain has several bioactive properties including inhibiting tumour growth, antithrombotic (inhibiting platelet aggregation and clot formation), fibrinolytic for skin debridement, promotion of wound healing, and anti-inflammatory. Medicinal uses for bromelain based on clinical studies includes treating cardiovascular disease, relieving symptoms of osteoarthritis, treating bacterial diarrhoea, limiting tumour growth, and debridement of burns. Bromelain is readily absorbed into the intestines without loss of bioactivity and is considered a useful dietary supplement as an oral enzyme33, 34, 35. Clinical and animal studies indicate that the anti-inflammatory properties of bromelain may help heal mucosal ulcers in inflammatory bowel disease, by inhibiting inflammatory mediators36. Colon biopsies from inflamed tissue of patients with ulcerative colitis, had decreased secretion of inflammatory cytokines37.

Trikatu blend

Trikatu is an ancient Sanskrit word meaning three spices or three peppers. Trikatu blend is based on an Ayurvedic (traditional Indian herbal medicine) formula of equal parts of the fruits of Black Pepper (Piper nigrum), Long Pepper (Piper longum) and the rhizomes of Ginger (Zingiber officinale). In traditional and contemporary herbal medicine, it is used to treat many ailments including cough and cold, respiratory infections, fever, gastrointestinal disorders, arthritis, liver diseases and diabetes38, 39.

Black pepper (Piper nigrum) and Long pepper (Piper longum):

Trikatu blend in Go Turmeric Digestion Eze contains BioPerine® which is a patented extract of black pepper standardised to 95% piperine, the major pharmacologically active component in both black and long pepper. Piperine is an alkaloid that gives pepper its pungent properties and has many bioactive properties including anti-inflammatory, by inhibiting production of inflammatory cytokines, antioxidant by acting as a free radicle scavenger, promoting digestion by stimulating pancreatic digestive enzymes and reducing the time food remains in the intestines, and inhibiting enzymes that metabolise drugs in the liver. Piperine also has anti-cancer and anti-ulcer properties39, 40, 41, 42. Piperine is used as a bioavailability enhancer, as it interacts with specific enzymes in the liver and intestinal wall that metabolise drugs and other bioactive compounds in preparation for their excretion, which means that they lose their bioavailability40, 43. Curcumin has low bioavailability as it undergoes rapid metabolism in the liver. Piperine significantly increased the bioavailability of curcumin when given to rats and healthy human volunteers together with curcumin13, 14.

Ginger (Zingiber officinale):

Ginger is a flowering plant belonging to the Zingiberaceae family that originated from in India and Southern Asia. The root of the ginger plant is used as a spice in cooking and for its medicinal properties and has been used in traditional medicine for digestive problems to calm upset stomachs and promotes digestive juices, for treating arthritis, and aches and pains among many others. Preclinical studies have indicated that ginger helps relieve symptoms of digestive problems including dyspepsia, flatulence, nausea and abdominal pain, and prevents gastric ulcers in animal models. Ginger also has antiemetic and gastroprotective properties44. Clinical studies have demonstrated that Ginger enhances gastrointestinal motility and stimulates gastric emptying in healthy volunteers and patients with functional dyspepsia45, 46.

What are the Contraindications/Interactions of Go Turmeric Digestion Eze?

There are no documented herb-drug interactions within the recommended dosage. However, you should always check the ingredients for known allergies and to ensure you do not have any allergies or sensitivities to these ingredients. Stop using if you develop any irritation or allergy while taking Go Turmeric Digestion Eze. Always read the label and use as directed or seek advice from your healthcare professional.

Caution:

If you are taking prescription medicines you should check with your doctor before using Go Turmeric Digestion Eze. Aloe vera and bromelain in Go Turmeric Digestion Eze may affect absorption of some medications.

Do not use if:
  • you are pregnant or while breast-feeding
  • you are taking anticoagulants like warfarin or anti-platelet medication like clopidogrel or aspirin (blood-thinning medications) 
  • you are allergic to pineapple, as bromelain is derived from pineapples

Side effects:

Aloe Vera can cause abdominal cramps and diarrhoea if you have Crohn’s disease or ulcerative colitis.

What are the Directions for using Go Turmeric Digestion Eze?

Take one vegeCapsule of Go Turmeric Digestion Eze once daily with food.

References

The following references provide scientific support for the use of this product:
  1. Asnaashari S, Siavash Dastmalchi S, Javadzadeh Y Gastroprotective effects of herbal medicines (roots). International J Food Properties 2018, Vol. 21, No. 1, 901–919
  2. Madrigal-Santillán E, Madrigal-Bujaidar E, Álvarez-González I, Sumaya-Martínez MT, Gutiérrez-Salinas J, et al. Review of natural products with hepatoprotective effects. World J Gastroenterol 2014 October 28; 20(40): 14787-14804
  3. Amalraj A, Pius A, Gopi S, Gopi S. Biological activities of curcuminoids, other biomolecules from turmeric and their derivatives—a review. J Tradit Complement Med. 2017;7:205-233.
  4. Mantzorou M, Pavlidou E, Vasios G, Tsagalioti E, Giaginis C. Effects of curcumin consumption on human chronic diseases: a narrative review of the most recent clinical data. Phytother Res. 2018;32:957-975. 
  5. Gupta SC, Patchva S, Aggarwal BB. Therapeutic roles of curcumin: lessons learned from clinical trials. AAPS J.2013 Jan;15(1):195-218. 
  6. He 1 Y, Yue Y, Zheng X, Zhang K, Chen S, Du Z. Curcumin, Inflammation, and Chronic Diseases: How Are They Linked? Molecules 2015, 20, 9183-9213
  7. Yadav SK, Sah AK, Sah RK, Sah JP, Shah DK. Turmeric (curcumin) remedies gastroprotective action. Pharmacogn Rev 2013 Jan-Jun; 7(13): 42–46. 
  8. Kim DC, Kim SH, Choi BH, Baek NI, Kim D, Kim MJ, et al. Curcuma longa extract protects against gastric ulcers by blocking H2 histamine receptors. Biol Pharm Bull. 2005;28:2220–4
  9. Peterson CT, Vaughn AR, Sharma V, Chopra D, Paul J. Mills PJ, Scott N. Peterson SN, Sivamani RK. Effects of Turmeric and Curcumin Dietary Supplementation on Human Gut Microbiota: A Double-Blind, Randomized, Placebo-Controlled Pilot Study. Journal of Evidence-Based Integrative Medicine Volume 23: 1-8
  10. Algieri F, Rodriguez-Nogales A, Rodriguez-Cabezas ME, Risco S, Ocete MA, Galvez J. Botanical Drugs as an Emerging Strategy in Inflammatory Bowel Disease: A Review. Mediators Inflamm. 2015;2015:179616. 
  11. Hanai H, Takayuki I, T, Takeuchi K, Watanabe F, Maruyama Y, et al. Curcumin maintenance therapy for ulcerative colitis: randomized, multicenter, double-blind, placebo-controlled trial. Clin Gastroenterol Hepatol 2006;4:1502- 1506.
  12. Mehta J, Rayalam S, Wang X. Cytoprotective Effects of Natural Compounds against Oxidative Stress. Antioxidants (Basel).2018 Oct 20;7(10). pii: E147. 
  13. Shoba G, Joy D, Joseph T, Majeed M, Rajendran R, Srinivas PS. Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med.1998 May;64(4):353-6. 
  14. Prasad S, Tyagi AM, Aggarwal BB. Recent Developments in Delivery, Bioavailability, Absorption and Metabolism of Curcumin: the Golden Pigment from Golden Spice Cancer Res Treat 2014 Jan; 46(1): 2–18.
  15. Sahu PK, Giri DD, Singh R, Pandey P, Gupta S, et al. Therapeutic and Medicinal Uses of Aloe vera: A Review. Pharmacology & Pharmacy, 2013, 4, 599-610
  16. Langmead L, Makins R, Rampton D. (2004). Anti-inflammatory effects of aloe vera gel in human colorectal mucosa in vitro. Aliment. Pharmacol. Ther. 2004; 19, 521–527. 
  17. Langmead L, Feakins RM, Goldthorpe S, Holt H, Tsironi E, et al. Randomized, double-blind, placebo-controlled trial of oral aloe vera gel for active ulcerative colitis. Aliment Pharmacol Ther 2004; 19: 739–747. 
  18. Triantafyllidi A, Xanthos T, Papalois A, Triantafillidis JK. Herbal and plant therapy in patients with inflammatory bowel disease. Ann Gastroenterol.2015 Apr-Jun;28(2):210-220.
  19. Akpan UP, Nna VU, Ekpenyong CE, Antai AB, Osim EE. Protective role of crude Aloe vera gel against gastric ulcers in alloxan - Induced diabetic rats. Res J Pharm Biol Chem Sci 2014; 5(2): 129-138.
  20. Eamlamnam K, Patumraj S, Visedopas N, Thong-Ngam D. Effects of aloe vera and sucralfate on gastric microcirculatory changes, cytokine levels and gastric ulcer healing in rats. World J Gastroenterol 2006; 12(13): 2034-2039.
  21. Panahi Y, Khedmat H, Valizadegan G, Mohtashami R, Sahebkar A. Efficacy and safety of Aloe vera syrup for the treatment of gastroesophageal reflux disease: a pilot randomized positive-controlled trial. J Tradit Chin Med.2015 Dec;35(6):632-6.
  22. Avijgan M, Kamran A, Abedini A. Effectiveness of Aloe Vera Gel in Chronic Ulcers in Comparison with Conventional Treatments. Iran J Med Sci.2016 May;41(3 Suppl):S30.
  23. Srivastava JK, Eswar Shankar E Gupta S. Chamomile: A herbal medicine of the past with bright future. Mol Med Report. 2010 Nov 1; 3(6): 895–901
  24. McKay DL, Blumberg JB. A review of the bioactivity and potential health benefits of chamomile tea (Matricaria recutita L.). Phytother Res 2006 Jul;20(7):519-30. 
  25. Cemek M, Yilmaz E, Büyükokuroğlu ME. Protective effect of Matricaria chamomilla on ethanol-induced acute gastric mucosal injury in rats. Pharmaceutical Biology, 2010; 48(7): 757–763
  26. Ebada ME. Essential oils of green cumin and chamomile partially protect against acute acetaminophen hepatotoxicity in rats An Acad Bras Cienc.2018 Aug;90(2 suppl 1):2347-2358. 
  27. McKay DL, Blumberg JB. A review of the bioactivity and potential health benefits of peppermint tea (Mentha piperita L.). Phytother Res. 2006 Aug;20(8):619-33. 
  28. Chumpitazi BP, Kearns GL, Shulman RJ. Review article: the physiological effects and safety of peppermint oil and its efficacy in irritable bowel syndrome and other functional disorders. Aliment Pharmacol Ther. 2018;47:738–752.
  29. Madisch A, Holtmann G, Mayr G, Vinson B, Hotz J.Treatment of functional dyspepsia with a herbal preparation. A double-blind, randomized, placebo-controlled, multicenter trial.Digestion.2004;69(1):45-52. Epub 2004 Jan 30. 2008;337:a2313
  30. Grigoleit HG, Grigoleit P. Peppermint oil in irritable bowel syndrome. Phytomedicine 2005 Aug;12(8):601-6. 
  31. Ford AC, Talley NJ, Spiegel BM, et al. Effect of fibre, antispasmodics, and peppermint oil in the treatment of irritable bowel syndrome: systematic review and meta-analysis. BMJ 2008; 337: a2313. 
  32. Merat S, Khalili S, Mostajabi P, Ghorbani A, Ansari R, Malekzadeh R. The effect of enteric-coated, delayed-release peppermint oil on irritable bowel syndrome. Dig Dis Sci.2010 May;55(5):1385-90. 
  33. Maurer HR. Bromelain: biochemistry, pharmacology and medical use. Cell Mol Life Sci.2001 Aug;58(9):1234-45. 
  34. Rathnavelu V, Alitheen NB, Sohila S, Samikannu KanagesanS, Ramesh R. Potential role of bromelain in clinical and therapeutic applications (Review). Biomed Rep. 2016 Sep; 5(3): 283–288.
  35. Pavan R, Jain S, Shraddha, Kumar A. Properties and therapeutic application of bromelain: a review. Biotechnol Res Int.2012;2012:976203. 
  36. Zhou Z, Wang L, Feng P, Yin L, Wang C. Inhibition of Epithelial TNF-α Receptors by Purified Fruit Bromelain Ameliorates Intestinal Inflammation and Barrier Dysfunction in Colitis. Front Immunol.2017 Nov 10;8:1468.
  37. Onken JE, Greer PK, Calingaert B, Haleb LP. Bromelain treatment decreases secretion of pro-inflammatory cytokines and chemokines by colon biopsies in vitro. Clin Immunol 2008; 126, 345-352. 
  38. Johri RK, Zutshi U. An Ayurvedic formulation 'Trikatu' and its constituents. J Ethnopharmacol.1992 Sep;37(2):85-91. 
  39. Hazra AK, Chakraborty B, Mitra A, Sur TK. A rapid HPTLC method to estimate piperine in Ayurvedic formulations containing plant ingredients of Piperaceae family. J Ayurveda Integr Med.2018 Oct 11. pii: S0975-9476(17)30214-0. 
  40. Singh A, Duggal S. Piperine: review of advances in pharmacology. Int J Pharm Sci Nanotech 2009;2:615e20.
  41. Srinivasan K. Black pepper and its pungent principle-piperine: a review of diverse physiological effects. Crit Rev Food Sci Nutr.2007;47(8):735-48.
  42. Meghwal M, Goswami TK. Piper nigrum and piperine: an update. Phytother Res.2013 Aug;27(8):1121-30. 
  43. Han HK. The effects of black pepper on the intestinal absorption and hepatic metabolism of drugs. Expert Opin Drug Metab Toxicol.2011 Jun;7(6):721-9. 
  44. Haniadka R, Saldanha E, Sunita V, Palatty PL, Fayad R, Baliga MS. A review of the gastroprotective effects of ginger (Zingiber officinale Roscoe). Food Funct.2013 Jun;4(6):845-55. 
  45. Fifi AC, Axelrod CH, Chakraborty P, Saps M. Herbs and Spices in the Treatment of Functional Gastrointestinal Disorders: A Review of Clinical Trials. Nutrients 2018, 10, 1715;
  46. Hu, M.-L.; Rayner, C.K.;Wu, K.-L.; Chuah, S.-K.; Tai,W.-C.; Chou, Y.-P.; Chiu, Y.-C.; Chiu,W.-K.; Hu, T.-H. Effect of ginger on gastric motility and symptoms of functional dyspepsia. World. J. Gastroenterol. 2011, 17, 105–110.