Go Healthy Go Milk Thistle 50,000 | 30 Vegetable Capsules

Go Healthy Go Milk Thistle 50,000 

What is Go Milk Thistle 50,000?

The liver is a complex and important organ that regulates the many processes involved in the metabolism and detoxification functions of the body. Go Milk Thistle 50,000 contains high strength Milk Thistle in each capsule, a natural herbal ingredient that supports healthy liver function and helps protect the liver from damage whilst it carries out its important functions.

Why use Go Milk Thistle 50,000?

Go Milk Thistle 50,000 contains high strength Milk Thistle in each capsule, a natural herb that supports healthy liver function. The liver is an important organ that pays a vital role in the metabolism of nutrients from our food, metabolism of any toxins we put into our body, including drugs, medications and alcohol, as well as the detoxification and elimination of waste products and chemicals from the body. The liver is easily damaged by many environmental factors, including drugs, alcohol and viral infection. This results in oxidative stress caused by the production of free radicles, which can cause diseases like hepatitis (inflammation of the liver) and cirrhosis (damage to liver cells). However, the liver has its own finely tuned processes to deal with this and produces several enzyme antioxidants to help combat potential damage, such as superoxide dismutase and glutathione peroxidase. Herbal remedies have long been used in many forms of traditional medicine to protect the liver^1. Go Milk Thistle is a natural herbal ingredient with known properties that supports healthy liver function and helps protect the liver from damage whilst it carries out its important functions.

What are the Key Benefits of Go Milk Thistle 50,000?

• Traditional medicinal plant formula
• Provides natural support for healthy liver function
• Protects the liver against damage from harmful substances
• Promotes liver regeneration
• Supports overall health and wellbeing
• Provides potent single daily dosing in vegecaps

What is hepatoprotective?

A hepatoprotective is a substance that has the ability to prevent damage to the liver. What is oxidative stress?A free radicle is an oxygen molecule that contains a single electron, which makes it highly reactive as it scavenges to find another unpaired electron, causing damage to lipids, proteins and DNA. Free radicles or reactive oxygen species (ROS) like superoxide and hydrogen peroxide and are also produced during normal metabolic and physiological process, such as apoptosis (programmed cell death) and cell proliferation; also, during carcinogenesis (cancer cell formation). There are also external factors that increase generation of free radicles including smoking, alcohol and ultraviolet irradiation from the sun. The body has its own antioxidant defence system that eliminates free radicles, to ensure a balance between generation and elimination of free radicles. If more free radicles are generated than eliminated, this causes oxidative stress which is damaging to the body.

What is an antioxidant?

An antioxidant substance that that protects the body from damage due oxidative stress, by inhibiting oxidation.

What are the Ingredients of Go Milk Thistle 50,000?

Each capsule of Go Milk Thistle contains the following ingredients:

• Milk Thistle 50,000mg (equivalent to dry fruit extract)

Milk Thistle (Silybum marianum):

Milk Thistle also known as St Mary’s Thistle is member of the Asteraceae/Compositae family that is native to Mediterranean regions but now grows ubiquitously. Milk Thistle has been used for centuries as a natural remedy for diseases of the liver and biliary tract and is now widely used to protect the liver against toxins and to control acute and chronic liver diseases^2. Extract of Milk Thistle contains several active hepatoprotective compounds collectively known as silymarin, which is a combination composed of flavonoids and lignin structures, known as flavolignins. Silybin which comprises 50-70% of the flavolignin component of Milk Thistle extract is the major bioactive component^{3, 4, 5.} Animal studies have demonstrated that hepatoprotective properties of silymarin are due to its antioxidant activity by inhibiting free radicle formation produced by toxins such as ethanol, acetaminophen, and carbon tetrachloride; also, by increasing glutathione and superoxide dismutase activity of liver cells (hepatocyte) and inhibiting lipid peroxidation, the enzyme that creates free radicles from cell membranes. Silymarin also prevents toxins entering liver cells, enhances hepatocyte protein synthesis and promotes hepatocyte regeneration^{3, 4, 6.} In addition to its hepatoprotective properties silymarin has been found to have anti-inflammatory and anti-cancer activity^{5, 7.} Animal studies have also demonstrated that silymarin inhibits the process of fibrosis and cirrhosis that lead to liver damage7. Preclinical and clinical studies have indicated that silymarin may be helpful in the treatment of viral hepatitis, alcoholic liver disease and liver disease caused by toxins^{7, 8, 9, 10, 11, 12.}

What are the Contraindications/Interactions of Go Milk Thistle 50,000?

You should always check the ingredients for known allergies and to ensure you do not have any allergies or sensitivities to these ingredients. Stop using if you develop any irritation or allergy while taking Go Milk Thistle. Always read the label and use as directed or seek advice from your healthcare professional. If you are taking any prescription medication seek advice from your doctor before you start taking Go Milk Thistle.

Do not use:

If you are pregnant or breastfeeding

Caution:

Go Milk Thistle should be used with caution if you:

• have diabetes as Milk Thistle may affect blood sugar levels
• are taking prescribed medication as Milk Thistle may affect the blood levels of several medications, such as warfarin, amitriptyline and verapamil
• have an oestrogen dependent or sensitive cancer, as St Mary’s Thistle may worsen your condition
• are taking oestrogen containing hormone medication, such as a hormone replacement, without discussion with your doctor

What are the Directions for using Go Milk Thistle 50,000?

Take one vegecapsule of Go Milk Thistle once daily, with or without food. Go Milk Thistle can be taken at any time.

Product Size

30 Vegetable Capsules

References

Hepatoprotective plants

1. Saleem TSM, Chetty CM, Ramkanth S, Rajan VST, Kumar KM, Gauthaman K. Hepatoprotective Herbs – A Review. Int. J. Res. Pharm. Sci. Vol-1, Issue-1, 1-5, 2010.
2. Flora K, Hahn M, Rosen H, Benner K. Milk thistle (Silybum marianum) for the therapy of liver disease. Am J Gastroenterol.1998 Feb;93(2):139-43.
3. Vargas-Mendoza N, Madrigal-Santillán E, Morales-González A, Esquivel-Soto J, Esquivel-Chirino C, et al. Hepatoprotective effect of silymarin. World J Hepatol 2014 March 27; 6(3): 144-149.
4. Madrigal-Santillán E, Madrigal-Bujaidar E, Madrigal-BujaidarIsela E, Álvarez-González I, Sumaya-Martínez MT, José Gutiérrez-Salinas J, et al. Review of natural products with hepatoprotective effects. World J Gastroenterol 2014 October 28; 20(40): 14787-14804
5. Bijak M. Silybin, a Major Bioactive Component of Milk Thistle (Silybum marianum L. Gaernt.)-Chemistry, Bioavailability, and Metabolism. Molecules.2017 Nov 10;22(11). pii: E1942.
6. Surai PF. Silymarin as a Natural Antioxidant: An Overview of the Current Evidence and Perspectives. Antioxidants (Basel).2015 Mar 20;4(1):204-47.
7. Federico A, Dallio M, Loguercio C. Silymarin/Silybin and Chronic Liver Disease: A Marriage of Many Years. Molecules 2017, 22, 191.
8. Abenavoli L, Capasso R, Milic N, Capasso F.Milk thistle in liver diseases: past, present, future. Phytother Res. 2010 Oct;24(10):1423-32.
9. Tamayo C, Diamond S. Review of Clinical Trials Evaluating Safety and Efficacy of Milk Thistle (Silybum marianum [L.] Gaertn.). Integrative Cancer Therapies 6(2); 2007 pp. 146-157.
10. Saller R, Brignoli R, Melzer J, Meier R. An updated systematic review with meta-analysis for the clinical evidence of silymarin. Forsch Komplementmed.2008 Feb;15(1):9-20.
11. Loguercio C, Festi D. Silybin and the liver: From basic research to clinical practice. World J Gastroenterol 2011 May 14; 17(18): 2288-2301
12. Hellerbrand C, Jörn M. Schattenberg JM, Philipp Peterburs P, Lechner A, Brignoli R. The potential of silymarin for the treatment of hepatic disorders. Clinical Phytoscience (2016) 2:7.