Go Healthy Go Meno-Free Menopause & Hot Flush Support | 30 VegeCapsules

Go Healthy Go Meno-Free Menopause & Hot Flush Support

What is Go Meno-Free Menopause & Hot Flush Support?

Menopause can be a difficult time for women as many aspects of her life become affected by hormonal changes. Go Meno-Free is a blend of natural herbal ingredients that support women through the changes that are triggered by hormonal fluctuations at menopause, by helping to manage irritability and mood swings, regulating temperature imbalances and promoting healthy sleep patterns.

Why use Go Meno-Free Menopause & Hot Flush Support?

Menopause is a time of change for women as fluctuating hormones levels affect mood, cognitive function, sleep patterns, loss of temperature regulation and also leads to physical changes. Levels of oestrogen and progesterone fall, and since these are the hormones that regulate the cycle of ovulation and menstruation, the regular menstrual cycle ceases. A lack of oestrogen causes a range of symptoms associated with menopause, including hot flushes, night sweats, sleep problems, vaginal dryness, headaches, mood swings, lack of concentration and loss of energy, as well as other metabolic changes such as redistribution of body fat and loss of bone mass. Go Meno-Free is a blend of natural herbal ingredients that support women through the natural hormonal changes of menopause by helping to manage irritability and mood swings, regulating temperature imbalances and promoting healthy sleep patterns.

What are the Key Benefits of Go Meno-Free Menopause & Hot Flush Support?

• Traditional medicinal plant formula 
• Natural ingredients that support balanced mood and temperature control
• Natural ingredients that support hormonal changes 
• Convenient once a day dosing
• Soy free formula
• Capsules are vegan and gluten and dairy free 
• Suitable for vegetarians and dairy or gluten intolerances  

What is menopause?

Menopause is a natural stage in a woman’s life, also known as climacteric, that usually begins around the age of 50, when oestrogen levels fall and menstruation stops. Menopause is defined as having been one year since the last menstrual bleed. Symptoms of menopause are caused by lack of oestrogen and include hot flushes, sweating, sleep disturbances, vaginal dryness, headaches, mood swings, lack of concentration and loss of energy, as well as metabolic changes such as redistribution of body fat and loss of bone mass.

What causes hot flushes?

Hot flushes are the sudden and overwhelming feelings of warmth that are a common symptom of menopause and are usually accompanied by sweating and blotchy redness of the skin. These vasomotor symptoms of menopause are caused by falling levels of oestrogen and increasing levels of follicle stimulating hormone (FSH). This influences the temperature regulatory centres in the hypothalamus of the brain, by increasing sensitivity to small changes in body temperature, resulting in dilation of blood vessels in the skin, which increases blood flow and body temperature.

What is the Menopause Rating Scale (MRS)?

The Menopause Rating Scale (MRS) is used as a measure of the impact of menopausal symptoms on health-related quality of life. It is a standardised self-administered scale used to assess menopausal symptoms, to evaluate the severity of symptoms over time, and measure changes due to treatment for menopausal symptoms^1.

What is an adaptogen?

An adaptogen is a plant-derived substance that helps the body manage the physiological effects of stress and adapt to the changes experienced, without unwanted or toxic side effects.

What is an anxiolytic?

An anxiolytic is a substance that can relieve anxiety, aid sleep, or have a calming effect.

What are the Ingredients of Go Meno-Free Menopause & Hot Flush Support?

Each capsule of Go Meno-Free contains the following ingredients:

• Black Cohosh (Actaea racemosa) 1,000mg (extract equivalent)
• Dong quai (Angelica sinensis) 1,200mg (extract equivalent)
• Kudzu (Pueraria lobata) 250mg (extract equivalent)
• Motherwort (Leonurus cardiaca) 250mg (extract equivalent)
• Red clover (Trifolium pratense) 1,000mg (extract equivalent)
• Chinese Foxglove (Rehmannia glutinosa) 1,200mg (extract equivalent)
• Sage (Salvia officinalis) 3,200mg (extract equivalent)
• Shatavari (Asparagus racemosus) 1,200mg (extract equivalent)
• Withania (Withania somnifera) 2,200mg (extract equivalent)
• Zizyphus (Zizyphus spp)

Black Cohosh (Actaea racemosa/Cimicifuga racemosa):

Black Cohosh is a flowering plant belonging to the Ranunculaceae (Buttercup) family that is native to North America. The roots and rhizome (underground stem) of Black Cohosh have been used by Native Americans for centuries as a traditional medicine for women’s health problems and to treat fever, cough and rheumatic pain. More recently Black Cohosh has been used as an alternative to hormone replacement therapy to relieve symptoms of menopause. There is some evidence from clinical studies to suggest that Black Cohosh is effective in relieving the vasomotor symptoms of menopause such as hot flushes and night sweats^{2, 3, 4.} clinical study indicated that Black Cohosh was also effective in improving sleep in postmenopausal women^5. Extract of the root of Black Cohosh contains several triterpene glycosides, flavonoids, aromatic acids like fukinolic acids and a resinoid substance called cimicifugin. The triterpene glycosides are thought to contribute to its pharmacological activity in relieving vasomotor menopausal symptoms. Black Cohosh does not appear to have estrogenic activity and it is thought to work by stimulating certain neurotransmitters, particularly serotonin and dopamine, to act on the hypothalamus, where temperature control is regulated^{3, 6, 7.}

Dong quai (Angelica sinensis):

Dong quai, also known as female ginseng, is an herb belonging to the Apiaceae family and native to the cool high areas of China. It has been used in traditional Chinese medicine for centuries for women’s health issues, including menstrual problems and infertility; also, for to promote blood circulation, and relieving pain. Dong quai extract has been used in contemporary herbal medicine for its anti-inflammatory, antioxidant, hypotensive (blood pressure lowering) and antithrombotic (inhibits blood blot formation) properties. Dong quai extract contains several bioactive chemicals including phthalides, ferulic acid, and coniferyl ferulate that contribute to its biological properties^8. The phthalide fraction in Dong quai extract contains compound called Z-ligustilide, which may have estrogenic activity, however, this compound is very unstable so that it has been difficult to confirm^9. A herbal combination containing Dong quai extract was found to improve menopausal symptoms, based on the validated Menopause Rating Scale (MRS) that measures the impact of menopausal symptoms on health-related quality of life. It was not clear whether this was due to oestrogenic effects or to interaction with the serotonin system^10.

Kudzu (Pueraria lobata)

Kudzu also known as Japanese arrowroot, is a climbing vine belonging to the Fabaceae (pea) family that is native to parts of Asia and some Pacific Islands. Extracts of the rood (radix) of Kudzu has been used in traditional medicine to treat diarrhoea, muscle stiffness, thirst, and diabetes. In contemporary herbal medicine Kudzu root extract is used as a vasodilator to treat heart conditions like angina and to prevent heart attack11. Kudzu root extract is rich in isoflavonoids such as formononetin, biochanin A, genistein, daidzein, and puerarin. Genistein and daidzein have been shown to bind to the oestrogen receptor in laboratory studies indicating oestrogenic activity. Puerarin the most abundant isoflavone in kudzu root is metabolized to daidzein by intestinal bacteria and may have beneficial effects on glucose and lipid metabolism in animal models^{11, 12, 13, 14.} Kudzu root extract may also have serotonergic activity (interacts with nerve cells that produce serotonin) that is involved in temperature regulation, as demonstrated in animal models^12.

Motherwort (Leonurus cardiaca):

Motherwort is a perennial herbaceous plant belonging to the Lamiaceae family, grown throughout Europe as well as other locations worldwide for its use in traditional herbal medicine for heart problems, nervous disorders, women’s health problems and digestive disorders. Motherwort contains several pharmacologically active compounds including flavonoids, diterpinoids, iridoids, seterols and tannins, and has several biological properties including antibacterial, antioxidant, anti-inflammatory, neuroprotective, analgesic, sedative and hypotensive (lowering blood pressure)^15. Leonurine is an alkaloid extracted from Motherwort which has several bioactive properties identified in animal models, including antidepressant-like and anxiolytic effects, mild vasodilator and relaxing effect on smooth muscles;^{16, 17} A clinical study with Motherwort extract demonstrated an improvement in symptoms of depression and anxiety in patients with arterial hypertension, supporting its previously reported anxiolytic properties^18. Animal studies indicate that Motherwort may support lipid regulation and may help combat weight gain in menopausal women^19.

Red clover (Trifolium pratense):

Red clover is a flowering plant belonging to the Fabaceae (pea) family that is native to Europe, Western Asia and Northern Africa, but grows the world over in open grassy places. In traditional herbal medicine extract of Red Clover was used as an anti-spasmodic, anti-inflammatory and for anti-cancer treatment, and in contemporary herbal medicine, it is primarily used as a supplement to relieve menopausal hot flushes. Red Clover extract contains isoflavone phytoestrogens including genistein and daidzein, which exist in Red Clover in an inactive form (formononetin and biochanin A) and are metabolised to the active form by the P-450 enzyme system in the intestine and the liver^{9, 12.} Oestrogenic activity of Red Clover extract has been demonstrated in vitro and in animal studies12, 20. Clinical studies have indicated that Red Clover extract may be effective in reducing the severity of menopausal symptoms using the validated Menopause Rating Scale (MRS) that measure the impact of menopausal symptoms on health-related quality of life^21. Clinical trials have also indicated that Red Clover extract, particularly phytoestrogens like genistein, may have benefits in relieving menopausal symptoms like hot flushes and night sweats^{22, 23.}

Chinese Foxglove (Rehmannia glutinosa):

Chinese Foxglove is a perennial herb belonging to the Scrophulariaceae family (but now provisionally assigned to the Orobanchaceae family) that is native to China and its root has been used in traditional Chinese medicine for arthritis, allergy and for women’s health problems; also, as an adrenal tonic. In contemporary herbal medicine, Chinese Foxglove root (radix) is used to treat allergic and inflammatory disorders involving the immune system, including arthritis and autoimmune diseases. Extract of Chinese Foxglove contains many bioactive compounds including iridoid glycosides like catalpol that is thought to be responsible for its biological and medicinal properties including antioxidant, anti-inflammatory, immunomodulatory and has pharmacological actions on the immune, endocrine system, cardiovascular and the nervous system^{24, 25.} Animal studies combining Chinese Foxglove with Kudzu indicated a possible role in regulating lipid metabolism, which may have relevance in postmenopausal obesity^26. There is also some clinical evidence to indicate that Chinese Foxglove may be helpful in managing postmenopausal osteoporosis^27.

Sage (Salvia officinalis):

Sage is a perennial shrub belonging to the Lamiaceae family that is native to the Mediterranean region and grown the world over for use as a cooking herb and for its medicinal properties for treating many disorders including seizure, ulcers, gout, rheumatism, inflammation, dizziness, tremor, paralysis, diarrhoea, and hyperglycaemia^{28, 29.} A range of pharmacologically active compounds have been identified in sage extracts including coumarins, flavonoids, tannins, terpenes and alkaloids. Clinical and experimental studies have demonstrated a range of properties due to these bioactive compounds including antitumour, antioxidant, anti-inflammatory, antiseptic, memory enhancing, and metabolic effects such as lipid and blood sugar lowering^28. In traditional and herbal medicine sage has been used for women’s health relating to hormonal fluctuations, including to help relieve hot flushes associated with menopause, and this property is thought to be due to the presence of oestrogenic flavonoids in sage extracts^30. This was supported by clinical studies in which the Menopause Rating Scale (MRS) was used to demonstrate that the severity, frequency and duration of menopausal flushing and night sweats were reduced by sage^{31, 32.}

Shatavari (Asparagus racemosus):

Shatavari is a species of asparagus belonging to the Asparagaceae family that grows throughout India, Nepal and Sri Lanka. The root has been used for centuries in traditional Indian Ayurvedic medicine for its many medicinal properties particularly women’s health issues, as a galactagogue to increase milk production, and for other health issues, including disorders of the nervous system, gastrointestinal system and cancer^33. Shatavari extract contains several pharmacologically active phytochemicals including steroidal saponins, also known as Shatavarins (which are phytoestrogens due to their ability to mimic human oestrogen), alkaloids (which have several medicinal properties) and flavonoids, which are powerful antioxidants with anti-inflammatory and immunosupportive properties. ^{33, 34} Due to its phytoestrogen component, Shatavari may be helpful in managing symptoms of menopause due to loss of oestroge^34.

Withania (Withania somnifera):

Withania also known as Ashwaganda, Indian Ginseng and Winter Cherry is a small shrub belonging to the Solanaceae (Nightshade) family that grows in hot dry climates. Withania root has been used in traditional Ayurvedic medicine for centuries as a tonic, for improving stamina and libido, for treating many ailments including inflammatory conditions like asthma and arthritis, and improving sleep. Withania has been identified as an adaptogen and reduces the stress response in animal models^{35, 36.} Withania extract contains many pharmacologically active compounds including alkaloids (isopelletierine, anaferine), steroidal lactones (withanolides, withaferins), saponins (sitoindoside), and withanolides (sitoindoside) that contribute to its biological properties including including antioxidant, anti-inflammatory, immunomodulatory, anti-tumour and anti-stress^{35, 36, 37.} Animal studies have indicated that Withania extract may have antidepressant and anti-anxiety activity, that is thought to be work through Gamma-aminobutyric acid (GABA), which is the main inhibitory neurotransmitter in the brain^37.

Zizyphus (Zizyphus spp):

Zizyphus, commonly known as Jujube, is a group of small shrubs belonging to the Rhamnaceae (Buckthorn) family that grow in many areas including the Mediterranean region, South West Asia, Western Africa, India and Brazil. The fruit of the Zizyphus bush has been used in traditional Chinese medicine for its mild sedative and calming properties, to relieve irritability and aid sleep. A clinical study demonstrated that when Zizyphus was included in a combined herbal formula, sleep quality was improved^38. Zizyphus fruit extract contains many bioactive compounds, including vitamin C, phenolics, flavonoids, triterpenes (jujubosides), saponins and polysaccharides, that contribute to its many properties such as anticancer, anti-inflammatory, anti-obesity, immunostimulant, antioxidant, hepatoprotective, and gastrointestinal protective^{39, 40.} In an animal study the sedative properties of Zizyphus fruit extract was found to be mainly due to the saponin component^41. Flavonoids extracted from Zizyphus leaves are associated with the antioxidant properties of Zizyphus^42.

What are the Contraindications/Interactions of Go Meno-Free Menopause & Hot Flush Support?

You should always check the ingredients for known allergies and to ensure you do not have any allergies or sensitivities to these ingredients. Stop using if you develop any irritation or allergy while taking Go Meno-Free. Always read the label and use as directed or seek advice from your healthcare professional.

Do not use if you:

• are pregnant or breastfeeding
• are taking blood thinning medication like warfarin as Dong quai may interact with warfarin to increase bleeding 
• have an oestrogen dependent or sensitive cancer, as the phytoestrogens in Go Meno-Free may worsen your condition
• are taking any hormone medication, such as a hormone replacement therapy for menopausal symptoms, without discussion with your doctor

Caution

If you are taking any prescription medication seek advice from your doctor before you start using Go Meno-Free.
Black Cohosh may cause mild gastrointestinal upset.

What are the Directions for using Go Meno-Free  Menopause & Hot Flush Support?

Take one VegeCapsule of Go Meno-Free once daily with food.

Product Size

30 VegeCapsules

References

The following references provide scientific support for the use of this product:

Nonhormonal Therapies for Hot Flashes in Menopause

1. Heinemann K, Ruebig A, Potthoff P, Hermann PG, Schneider HP, et al. The Menopause Rating Scale (MRS) scale: A methodological review. Health Qual Life Outcome 2004, 2:45
2. Leach MJ, Moore V. Black cohosh Cimicifuga spp.) for menopausal symptoms. Cochrane Database Syst Rev. 2012 Sep 12;(9):CD007244. 
3. Mehrpooya M, Rabiee S, Larki-Harchegani A, Fallahian AM, Moradi A et al. A comparative study on the effect of “black cohosh” and “evening primrose oil” on menopausal hot flashes. J Educ Health Promot2018; 7: 36.
4. Shahnazi M, Nahaee J, Mohammad-Alizadeh-Charandabi S, Bayatipayan S. Effect of black cohosh (cimicifuga racemosa) on vasomotor symptoms in postmenopausal women: a randomized clinical trial. J Caring Sci.2013 Jun 1;2(2):105-13. 
5. Jiang K, Jin Y, Huang L, Feng S, Hou X, et al. Black cohosh improves objective sleep in postmenopausal women with sleep disturbance. Climacteric. 2015;18(4):559-67. 
6. Guo Y, Yin T, Wang X, Zhang F, Pan G,et al. Traditional uses, phytochemistry, pharmacology and toxicology of the genus Cimicifuga: A review. J Ethnopharmacol.2017 Sep 14;209:264-282. 
7. Wuttke W, Jarry H, Haunschild J, Stecher G, Schuh M, Seidlova-Wuttke D. The non-estrogenic alternative for the treatment of climacteric complaints: Black cohosh (Cimicifuga or Actaea racemosa). J Steroid Biochem Mol Biol. 2014 Jan;139:302-10 
8. Wei WL, Zeng R, Gu CM, Qu Y, Huang LF, et al. Angelica sinensis in China-A review of botanical profile, ethnopharmacology, phytochemistry and chemical analysis. J Ethnopharmacol.2016 Aug 22;190:116-41. 
9. Dietz BM, Hajirahimkhan A, Dunlap TL, Bolton JL. Botanicals and Their Bioactive Phytochemicals for Women's Health. Pharmacol Rev.2016 Oct;68(4):1026-1073.
10. Trimarco V, Rozza FIzzo R, De Leo V, Cappelli V, et al. Effects of a new combination of nutraceuticals on postmenopausal symptoms and metabolic profile: a crossover, randomized, double-blind trial. Int J Womens Health.2016 Oct 11;8:581-587. 
11. Zhang Z, Lam TN, Zuo Z. . Radix Puerariae: an overview of its chemistry, pharmacology, pharmacokinetics, and clinical use. J Clin Pharmacol.2013 Aug;53(8):787-811
12. Hajirahimkhan A, Dietz BM, Bolton JL Botanical modulation of menopausal symptoms: mechanisms of action? Planta Med.2013 May;79(7):538-53. 
13. Zhou YX, Zhang H, Peng C. Puerarin: a review of pharmacological effects. Phytother Res.2014 Jul;28(7):961-75. 
14. Prasain J.K., Peng N., Rajbhandari R., Wyss J.M. The Chinese Pueraria root extract (Pueraria lobata) ameliorates impaired glucose and lipid metabolism in obese mice. Phytomed. Int. J. Phytother. Phytopharmacol. 2012;20:17–23
15. Wojtyniak K, Szymański M, Matławska I Leonurus cardiaca L. (motherwort): a review of its phytochemistry and pharmacology. Phytother Res. 2013 Aug;27(8):1115-20. 
16. Rezaei A, Issabeagloo E, Kordlar J. Study of Sedative, Preanaesthetic and Anti-anxiety Effects of Herbal Extract of Motherwort (Leonuruscardiac) in Comparison with Diazepam in rat. Bull. Env. Pharmacol. Life Sci., Vol 3 (2) January 2014: 67-71
17. Jia M, Li C, Zheng Y, Ding X, Chen M, et al. Leonurine Exerts Antidepressant-Like Effects in the Chronic Mild Stress-Induced Depression Model in Mice by Inhibiting Neuroinflammation. International Journal of Neuropsychopharmacology (2017) 20(11): 886–895
18. Shikov AN, Pozharitskaya, ON,Makarov V, GDemchenko DV, Shikh EV. Effect of Leonurus cardiaca oil extract in patients with arterial hypertension accompanied by anxiety and sleep disorders. Phytother Res.2011 Apr;25(4):540-3. 
19. Kim J, Kim MH, Choi YY, Hong J, Yang WM. Inhibitory effects of Leonurus sibiricus on weight gain after menopause in ovariectomized and high-fat diet-fed mice. Journal of Natural Medicines July 2016, Volume 70, Issue 3, pp 522–530
20. Overk CR, Yao P, Chadwick LR, Nikolic D, Sun Y, Cuendet MA, Deng Y, Hedayat AS, Pauli GF, Farnsworth NR, van Breemen RB, Bolton JL. Comparison of the in vitro estrogenic activities of compounds from hops (Humulus lupulus) and red clover (Trifolium pratense). J Agric Food Chem. 2005;53:6246–6253
21. Shakeri F, Taavoni S, Goushegir A, and Haghani H. Effectiveness of red clover in alleviating menopausal symptoms: a 12-week randomized, controlled trial. Climacteric 201518:568–573.
22. Lethaby A, Marjoribanks J, Kronenberg F, Roberts H, Eden J, and Brown J. Phytoestrogens for menopausal vasomotor symptoms. Cochrane Database Syst Rev 201312:CD001395.
23. Ghazanfarpour M, Sadeghi R, Roudsari RL, Khorsand I, Khadivzadeh T, Muoio B. Red clover for treatment of hot flashes and menopausal symptoms: A systematic review and meta-analysis. J Obstet Gynaecol. 2016 36 (3): 301–11. 
24. Zhang RX, Li MX, Jia ZP. Rehmannia glutinosa: review of botany, chemistry and pharmacology. J Ethnopharmacol.2008 May 8;117(2):199-214. 
25. Kim SH, Yook TH, Kim JU. Rehmanniae Radix, an Effective Treatment for Patients with Various Inflammatory and Metabolic Diseases: Results from a Review of Korean Publications. J Pharmacopuncture.2017 Jun;20(2):81-88.
26. Lee YH, Jin B, Lee S, Oh JY, Song J, et al. Evid Based Complement Alternat Med.2017;2017:8641535. A Herbal Formula HT051, a Combination of Pueraria lobate and Rehmannia glutinosa, Prevents Postmenopausal Obesity in Ovariectomized Rats.
27. Liu C, Ma R, Wang L, Zhu R, Liu H, et al. Rehmanniae Radix in osteoporosis: A review of traditional Chinese medicinal uses, phytochemistry, pharmacokinetics and pharmacology. J Ethnopharmacol.2017 Feb 23;198:351-362. 
28. Ghorbani A, Esmaeilizadeh M. Pharmacological properties of Salvia officinalis and its components. Journal of Traditional and Complementary Medicine 7 (2017) 433 440
29. Garcia C.S.C., Menti C., Lambert A.P.F. Pharmacological perspectives from Brazilian Salvia officinalis (Lamiaceae): antioxidant, and antitumor in mammalian cells. An Acad Bras Ciênc. 2016;88:281–292.
30. Rahte S, Evans R, Eugster PJ, Marcourt L, Wolfender JL, Kortenkamp A, Tasdemir D. Salvia officinalis for hot flushes: towards determination of mechanism of activity and active principles. Planta Med.2013 Jun;79(9):753-60. 
31. Bommer S, Klein P, Suter A. First time proof of sage's tolerability and efficacy in menopausal women with hot flushes. Adv Ther.2011 Jun;28(6):490-500. 
32. Rad S, Sedighe F, Dehaghani AS, Vafaei H, Sayadi M, Asadi M. The effect of salvia officinalis tablet on hot flashes, night sweating, and estradiol hormone in postmenopausal women. International Journal of Medical Research & Health Sciences, 2016, 5, 8:257-263. 
33. Alok S, Jain SK, Verma A, Kumar M, Mahor A, Sabharwal M. Plant profile, phytochemistry and pharmacology of Asparagus racemosus (Shatavari): A review. Asian Pac J Trop Dis. 2013 Jun; 3(3): 242–251.
34. Bopana N, Saxena S. Asparagus racemosus--ethnopharmacological evaluation and conservation needs. J Ethnopharmacol. 2007 Mar 1;110(1):1-15. 
35. Bhattacharya SK, Muruganandam AV. Adaptogenic activity of Withania somnifera: an experimental study using a rat model of chronic stress. Pharmacol Biochem Behav.2003 Jun;75(3):547-55.
36. Mishra LC, Singh BB, Dagenais S. Scientific basis for the therapeutic use of Withania somnifera (ashwagandha): a review. Altern Med Rev.2000 Aug;5(4):334-46.
37. Singh G, Sharma PK, Dudhe R, Singh S. Biological activities of Withania somnifera. Annals of Biological Research, 2010, 1 (3):56-63
38. Scholey A, Benson S, Gibbs A, Perry N, Sarris J, Murray G. Exploring the Effect of Lactium™ and Zizyphus Complex on Sleep Quality: A Double-Blind, Randomized Placebo-Controlled Trial. Nutrients.2017 Feb 17;9(2). pii: E154.
39. Gao QH, Wu CS, Wang M. The jujube (Ziziphus jujuba Mill.) fruit: a review of current knowledge of fruit composition and health benefits. J Agric Food Chem.2013 Apr 10;61(14):3351-63. 
40. Mahajan RT, Chopda MZ. Phyto-Pharmacology of Ziziphus jujube Mill- A plant review Pharmacognosy Reviews 2009; 3(6):320-329. 
41. Jiang J.G., Huang X.J., Chen J., Lin Q.S. Comparison of the Sedative and Hypnotic Effects of Flavonoids, Saponins, and Polysaccharides Extracted From Semen Ziziphus Jujube. Nat. Prod. Res. 2007;21:310–320.
42. Zhang L, Liu P, Li L, Huang Y, Pu Y, Hou X, Song L. Identification and Antioxidant Activity of Flavonoids Extracted from Xinjiang Jujube (Ziziphus jujube Mill.) Leaves with Ultra-High Pressure Extraction Technology. Molecules.2018 Dec 30;24(1). pii: E122.