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Go Healthy Go Man Plus Libido Support | 30 VegeCapsules

Go Healthy Go Man Plus Libido Support | 30 VegeCapsules

$38.22
$38.22
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Go Healthy Go Man Plus Libido Support 

What is Go Man Plus?

Go Man Plus is a blend of natural herbal extracts, and other ingredients designed to promote healthy sexual function in men by supporting healthy libido, enhancing sexual energy and improving stamina and energy.

Why use Go Man Plus?

As men age particularly after the age of 40, libido or sex drive (desire and interest in sex) may fall and can become a cause for concern. This is usually due to low or reduced levels of testosterone, the male hormone that promotes male characteristics, as well as regulating libido. Go Man Plus is a blend of natural herbal extracts, minerals and other ingredients that work together to promote healthy sexual function in men by supporting healthy libido, enhancing sexual energy and improving stamina and energy, as well as supporting healthy testosterone levels.

What are the Key Benefits of Go Man Plus?

  • Natural Aphrodisiac
  • Natural herbal ingredients
  • Supports healthy testosterone production
  • Enhances sexual health
  • Promotes healthy sexual function
  • Improves libido
  • Boosts circulation
  • Helps to treat conditions like impotence (erectile dysfunction or ED)
  • Normalizes cortisol levels
  • May help to increase lean muscle mass
  • May help to prevent bone loss
  • Once daily vegetable based capsule

What is testosterone and dihydrotestosterone (DHT)?

Testosterone is the male hormone that is responsible for normal growth and development of the testes and prostate gland, as well as stimulating male characteristics, such as body hair, increased muscle and bone mass and a deeper voice. It also regulates libido, maintains fertility by supporting sperm production, and supports the production of red blood cells. Testosterone is produced in the testes and a small proportion (around 10%) is converted to its potent metabolite dihydrotestosterone (DHT) by the action of the enzyme 5α-reductase. DHT is the androgen that is primarily responsible for development and growth of the prostate gland and is also thought to be involved in the uncontrolled growth of prostate cells leading to benign prostatic hyperplasia (BPH) and prostate cancer.

What is erectile dysfunction?

Erectile dysfunction, commonly known as impotence, is the inability to achieve or maintain a hard erect penis suitable for sexual activity, due to insufficient blood flow into the penis.
During sexual stimulation nitric oxide (NO) is released from the sensory neurones and the endothelial cells (cells lining blood capillaries) into the spongy erectile tissue of the penis, the corpora cavernosa, which activates the enzyme guanylate cyclase. This enzyme increases levels of a chemical called cyclic guanosine monophosphate (cGMP), which relaxes the blood vessels in the penis and allows blood to fill the corpora cavernosa, to cause an erection. Another enzyme called phosphodiesterase type 5 (PDE5) breaks down cGMP preventing blood flow into the penis, which causes loss of an erection. Inhibition of PDE5 is the basis of PDE5 inhibitors used for treatment of erectile dysfunction.

What causes loss of libido?

Loss of libido or the desire for sex is usually associated with falling testosterone levels, but can be related to other factors, such as depression, chronic illness, stress and side effects of some medications.

What is an aphrodisiac?

In popular culture, an aphrodisiac is a substance that can increase libido. It is not the same as a medical solution for a physical condition such as erectile dysfunction, that can be treated with medication.

What is an adaptogen?

An adaptogen is a plant-derived substance that helps the body manage the physiological effects of stress and adapt to the changes experienced, without unwanted or toxic side effects.

What are the Ingredients of Go Man Plus?

Go Man Plus blends a selection of herbal extracts, some of which have been used in traditional medicine for thousands of years to support general and sexual health and well-being.

Each capsule of Go Man Plus contains the following ingredients:

  • Saw Palmetto (Serenoa repens) 100mg (extract equivalent to dry fruit) 
  • Korean Ginseng (Panax ginseng) 500mg (extract equivalent to dry root) 
  • Tribulus terrestris 7000 (extract equivalent to dry fruit) 
  • Damiana (Turnera diffusa) 400mg (extract equivalent to dry herb) 
  • Muira Puama 2000mg (extract equivalent to dry herb) 
  • Horny Goat Weed (Epimedium) 15,000 (extract equivalent to dry herb) 
  • Ginkgo Biloba 1000mg (extract equivalent to dry leaf) 
  • Deer Velvet 100mg L-Arginine 100mg

Key Ingredients:

Saw Palmetto (Serenoa Repens):

Saw Palmetto extract is made from berries of Serenoa Repens commonly known as Saw Palmetto, a small palm tree found in Florida and the South Eastern states of the USA. Saw palmetto was used in traditional medicine by native Americans for urinogenital health problems. The extract is rich in fatty acids and phytosterols and has anti-androgen activity, meaning that it inhibits the conversion of the male hormone testosterone to its more potent metabolite dihydrotestosterone (DHT) by the enzyme 5α-reductase1. Saw Palmetto extract has also been found to have other properties, including anti-inflammatory and anti-proliferative, which in combination with its antiandrogenic properties are thought to support healthy prostate function, by helping to protect against benign prostatic hyperplasia (BPH)2. Animal studies have suggested that Saw Palmetto extract may be helpful in the treatment of erectile dysfunction3. In a study of elderly men with enlarged prostate and BHP, Saw Palmetto extract improved symptoms of sexual dysfunction indicating a possible role in treatment of erectile dysfunction4.

Panax Ginseng: 

Panax Ginseng, also known as Korean, Chinese or Red Ginseng, is a perennial plant that grows in the mountains of Eastern Asia. The root of Panax Ginseng has been used as a traditional medicine for thousands of years to enhance and restore health and well-being, improve energy levels, and to enhance sexual performance. In contemporary herbal medicine extract of Panax ginseng root is used to enhance physical performance, promote vitality, improve resistance to stress and support a healthy immune system5, 6, 7. Panax ginseng has been described as an adaptogen due to these many medicinal properties and the main pharmacologically active component in Panax ginseng extract that contributes to its properties is the triterpenoid saponin component known as ginsenoside5. Panax Ginseng extract is also used as an alternative treatment for erectile dysfunction6, 8, and is supported by a review of clinical studies that have indicated that Panax Ginseng extract is effective in the treatment of erectile dysfunction7. The mechanism by which Panax Ginseng extract is thought to work is by relaxation of the smooth muscle of the corpus cavernosum (erectile tissue in the penis) by increasing release of nitric oxide, which improves blood flow to the penis, rather than by increasing levels of testosterone7.

Tribulus terrestris:

Tribulus terrestris is a flowering plant in the family Zygophyllaceae and is also known by several common names, including puncture vine and devils weed. It is native to warm temperate and tropical regions and has been used as a traditional herbal remedy for thousands of years in Greece, China and India to treat several conditions, including cardiovascular disease, urinary tract infections and inflammation. It is also used as an aphrodisiac to improve sexual function, particularly for its male libido enhancing properties9, 10, 11. The main pharmacologically active components of Tribulus terrestris are flavonoids and saponins. Protodioscin, a steroidal saponin that is thought to contribute to the aphrodisiac and pro-erectile properties of the Tribulus terrestris. Animal studies found that Tribulus terrestris extract increased testosterone levels12. Other saponins in Tribulus terrestris extract, like tribulosin may have cardiovascular benefits and these effects are thought to be related to vasodilator and smooth muscle relaxation properties of Tribulus terrestris saponins10. Outcomes of a review of animal and human studies indicated that Tribulus terrestris has a role to play in treating erectile dysfunction and improving libido, and the mechanism is more likely to be by stimulating release of nitric oxide, which improves blood flow to the penis, rather than by increasing levels of testosterone13.

Damiana (Turnera diffusa/aphrodisiaca):

Damiana is a shrub that grows in hot humid climates and is native to central America. As a traditional herb Damiana was used as a tonic to help with sexual problems and as an aphrodisiac, since it was thought to mimic the actions of testosterone. It was also used as a relaxant and anxiolytic, to relieve stress and anxiety. Animal studies have demonstrated a stimulating effect of Damiana on sexual behaviour and this is thought to be due to apigenin, the major pharmacologically active component14, 15.

Muira Puama:

Muira Puama is a flowering plant native to the Amazon rainforest and is known locally as “Potency wood”. It has been used in South American herbal medicine for its many properties including as an aphrodisiac and to help with loss of libido. In an animal study a combination of herbal extracts including Muira Puama improved age related erectile dysfunction by stimulating the nitric oxide effect on increasing blood flow to the pelvic area, which helps maintain and enhance an erection16.

Horny Goat Weed (Epimedium):

Horny Goat Weed, also known as Epimedium barrenwort is a flowering plant found mainly in China and used in traditional Chinese medicine to increase fertility and improve sexual performance. Horny Goat Weed contains the flavonoid icaritin thought to be a natural aphrodisiac with pro-erectile properties17. In vitro and animal studies have demonstrated that isolated icaritin inhibits the enzyme phosphodiesterase type 5 (PDE5), indicating that it may be helpful for erectile dysfunction17, 18, 19. In an animal model, icaritin also demonstrated testosterone mimetic properties (has testosterone-like activity), which may be helpful in boosting testosterone levels20.

Ginkgo biloba:

Ginkgo Biloba, also known as maidenhair tree, is the oldest living tree and has long been used as a traditional medicine for treating blood disorders and improving memory. Ginkgo leaves contain flavonoids and terpenoids, both of which are antioxidants, and Ginkgo Biloba leaf extract is thought to have cardioprotective and cerebrovascular protective properties. Animal studies have demonstrated that Ginkgo Biloba leaf extract has vasodilator properties and causes relaxation of blood vessels to improve blood flow through the microcirculation due to increased nitric oxide production21, and this property is thought to help with erectile dysfunction22.

Deer Velvet:

Deer velvet is the name given to deer antlers during their rapidly growing stage, when they are soft and covered in fine hair that gives them the feel of velvet. In traditional Chinese medicine deer velvet has been used as a restorative tonic for body strengthening, blood cell production, the immune system, cardiovascular health and function and as an aphrodisiac. Current research supports many health benefits, particularly in regenerative medicine23. Deer velvet is rich in growth factors including insulin-like growth factor (IGF), epidermal growth factor (EGF) and transforming growth factor-β (TGF-β) that have a variety of effects on many cells type, and play a role in cell growth and regeneration, which are important for wound healing24, 25. Biologically active peptides have also been isolated from deer velvet, including Velvet Antler Polypeptide (VAP) that was found to improve sexual function and enhance testosterone synthesis in an animal model26.

L-Arginine:

L-arginine is an amino acid (protein building block) and is also a precursor of nitric oxide, a cellular messenger molecule that is important for maintaining normal blood flow by regulating vasodilation (relaxation of vascular smooth muscle) and causing dilation (widening) of blood vessels. This is an important mechanism involved in the process of obtaining and maintaining an erection. There is some clinical evidence that low levels of L-arginine are associated with erectile dysfunction27, and supplementation with L-arginine may improve sexual function22. The outcome of a review of studies into the role of diet and lifestyle on sexual function indicated that a diet rich in L-arginine, such as the Mediterranean diet, as part of a healthy lifestyle, may support healthy sexual function and reduce risk of erectile dysfunction28.

What are the Contraindications/Interactions of Go Man Plus?

You should consult your doctor if you have any concerns about taking Go Man Plus and discuss any prescription medication you are taking, before you begin taking Go Man Plus. Always check the ingredients for known allergies and to ensure you do not have any allergies or sensitivities to these ingredients. Stop using if you do develop any irritation or allergy while taking Go Man Plus.

Caution:

If you are taking any prescription medicines or you have a medical condition you should consult your doctor or healthcare professional before taking Go Man Plus.

Do not use if you:
  • have epilepsy and are taking anticonvulsants like carbamazepine as ginkgo in Go Man Plus may cause seizures 
  • have a bleeding condition or are taking anticoagulant or blood thinning drugs like warfarin, digoxin, clopidogrel and aspirin as Go Man Plus may increase bleeding
  • are taking medication for high blood pressure as Go Man Plus may lower blood pressure
  • have a heart condition and are taking medications 
Side effects:

Side effects of saw palmetto in Go Man Plus can include gastrointestinal upset (stomach pain, nausea, vomiting, constipation or diarrhoea), low libido, breast tenderness.

What is the Dosage Recommendation for Go Man Plus?

Adults:

Take 1 VegeCapsule daily either with food or on an empty stomach.

Product Size:

30 VegeCapsules

References

The following references provide scientific support for the use of this product:
  1. Penugonda K, Lindshield BL. Fatty acid and phytosterol content of commercial saw palmetto supplements. Nutrients 2013 Sep 13;5(9):3617-33.
  2. Geavlete P, Multescu R, Geavlete B. Serenoa repens extract in the treatment of benign prostatic hyperplasia. Ther Adv Urol (2011) 3(4) 193_198
  3. Yang S, Chen C, Li Y, Ren Z, Zhang Y. Saw palmetto extract enhances erectile responses by inhibition of phosphodiesterase 5 activity and increase in inducible nitric oxide synthase messenger ribonucleic acid expression in rat and rabbit corpus cavernosum. Urology.2013 Jun;81(6):1380.e7-13. 
  4. Suter A, Saller R, Riedi E, Heinrich M. Improving BPH symptoms and sexual dysfunctions with a saw palmetto preparation? Results from a pilot trial. Phytother Res.2013 Feb;27(2):218-26. 
  5. Kim D-H. Chemical Diversity of Panax ginseng, Panax quinquifolium, and Panax Notoginseng. J. Ginseng Res. Vol. 36, No. 1, 1-15 2012.
  6. Choi YD, Park CW, Jang J, Kim SH, Jeon HY, Kim WG, Lee SJ, Chung WS. Effects of Korean ginseng berry extract on sexual function in men with erectile dysfunction: a multicenter, placebo-controlled, double-blind clinical study. Int J Impot Res 2013 Mar-Apr;25(2):45-50.
  7. Jang DJ, Lee MS, Shin BC, Lee YC, Ernst E. Red ginseng for treating erectile dysfunction: a systematic review. Br J Clin Pharmacol. 2008 Oct;66(4):444-50. 
  8. Kim TH, Jeon SH, Hahn EJ, Paek KY, Park JK, Youn NY, Lee HL. Effects of tissue-cultured mountain ginseng (Panax ginseng CA Meyer) extract on male patients with erectile dysfunction. Asian J Androl 2009 May;11(3):356-61.
  9. Kam SC, Do JM, Choi JH, Jeon BT, Roh GS, Hyun JS. In vivo and in vitro animal investigation of the effect of a mixture of herbal extracts from Tribulus terrestris and Cornus officinalis on penile erection. J Sex Med. 2012 Oct;9(10):2544-51. 
  10. Chhatre S, Nesari T, Somani G, Kanchan D, Sathaye S. Phytopharmacological overview of Tribulus terrestris. Pharmacogn Rev. 2014 Jan-Jun; 8(15): 45–51. 
  11. Qureshi A, Naughton DP, Petroczi A. A systematic review on the herbal extract Tribulus terrestris and the roots of its putative aphrodisiac and performance enhancing effect. J Diet Suppl.2014 Mar;11(1):64-79. 
  12. Gauthaman K, Ganesan AP. The hormonal effects of Tribulus terrestris and its role in the management of male erectile dysfunction--an evaluation using primates, rabbit and rat. Phytomedicine. 2008 Jan;15(1-2):44-54 
  13. Neychev V, Mitev V. Pro-sexual and androgen enhancing effects of Tribulus terrestris L.: Fact or Fiction. J Ethnopharmacol.016 Feb 17;179:345-55
  14. Kumar S, Madaan R, Sharma A. Estimation of Apigenin, an Anxiolytic Constituent, in Turnera aphrodisiaca. Indian J Pharm Sci 2008 Nov;70(6):847-51. 
  15. Szewczyk K, Zidorn C. Ethnobotany, phytochemistry, and bioactivity of the genus Turnera (Passifloraceae) with a focus on damiana--Turnera diffusa. J Ethnopharmacol.2014 Mar 28;152(3):424-43. 
  16. Ferrini MG, Hlaing SM, Chan A, Artaza JN. Treatment with a combination of ginger, L-citrulline, muira puama and Paullinia cupana can reverse the progression of corporal smooth muscle loss, fibrosis and veno-occlusive dysfunction in the aging rat. Andrology (Los Angel) 2015 Jun;4(1).
  17. Shindel AW, Xin ZC, Lin G, Fandel TM, Huang YC, Banie L, Breyer BN, Garcia MM, Lin CS Lue TF. Erectogenic and neurotrophic effects of icariin, a purified extract of horny goat weed (Epimedium spp.) in vitro and in vivo. J Sex Med 2010 Apr;7(4 Pt 1):1518-28.
  18. Dell'Agli M, Galli GV, Dal Cero E, Belluti F, Matera R, Zironi E, Pagliuca G, Bosisio E. Potent inhibition of human phosphodiesterase-5 by icariin derivatives. J Nat Prod. 2008; 71:1513–7.
  19. Ning H, Xin ZC, Lin G, Banie L, Lue TF, Lin CS. Effects of icariin on phosphodiesterase-5 activity in vitro and cyclic guanosine monophosphate level in cavernous smooth muscle cells. Urology.
  20. Zhang ZB, Yang QT. The testosterone mimetic properties of icariin. Asian J Androl. 2006; 8:601–5.
  21. Koltermann A, Hartkorn A, Koch E, Fürst R, Vollmar AM, Zahler S. Ginkgo biloba extract EGb 761 increases endothelial nitric oxide production in vitro and in vivo. Cell Mol Life Sci. 2007 Jul;64(13):1715-22. 
  22. McKay D. Nutrients and botanicals for erectile dysfunction: examining the evidence. Altern Med Rev 2004 Mar;9(1):4-16.
  23. http://www.velvet.org.nz/what-is-velvet/velvet-research 
  24. Zang ZJ, Tang HF, Tuo Y, Xing WJ, Ji SY, Gao Y, Deng CH. Effects of velvet antler polypeptide on sexual behavior and testosterone synthesis in aging male mice. Asian J Androl. 2016 Jul-Aug;18(4):613-9. 
  25. Pita-Thomas W, Fernandez-Martos C, Yunta M, Maza RM, Navarro-Ruiz R, Lopez-Rodriguez MJ, Reigada D, Nieto-Sampedro M, Nieto-Diaz M. Gene expression of axon growth promoting factors in the deer antler. PLoS. One. 2010;5:e15706
  26. Gu L, Mo E, Yang Z, et al. Effects of red deer antlers on cutaneous wound healing in full-thickness rat models. Asian-Australasian Journal of Animal Sciences. 2008;21(2):277–290.
  27. Barassi A, Corsi Romanelli MM, Pezzilli R, Damele CA, et al. Levels of l-arginine and l-citrulline in patients with erectile dysfunction of different etiology. Andrology 2017 Mar;5(2):256-261. 
  28. McKay D. Nutrients and botanicals for erectile dysfunction: examining the evidence. Altern Med Rev 2004 Mar;9(1):4-16.