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Clinicians Flora Restore | 30 Capsules

Clinicians Flora Restore | 30 Capsules

$30.39
$30.39
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Clinicians Flora Restore

What is  Flora Restore?

Flora Restore is a unique oral probiotic formulation that has been designed to help support urogenital health (Vaginal and Urinary Tract), as well as restoration and maintenance of healthy flora.

Why use Flora Restore?

A healthy flora or microbiota, which is the complete collection of microorganisms that inhabit our body, is important for maintaining a balance between “good” bacteria, that provide several health benefits, and potentially pathogenic bacteria that can cause diseases. Flora Restore is an oral probiotic containing live beneficial bacteria that support urinogenital health in women by maintaining a healthy balanced flora in the vagina, bladder and urinary tract.

What are the Key Benefits of Flora Restore?

  • Clinically researched probiotics that support urinogenital health in women 
  • Formulated with a combination of two specific lactobacilli probiotics that populate the vagina and urinary tract
  • Natural ingredients that support a healthy vaginal flora
  • Suitable for women of all ages and stages in life
  • Supports vaginal health in menopause
  • Maintains a healthy vaginal flora when preparing for pregnancy
  • Capsules contain no added gluten, artificial colours, sweeteners, flavours or preservatives
  • This product can be taken whilst pregnant and breastfeeding.

Indications:

  • Urinary tract infections.
  • Vaginal yeast infections.
  • Bowel problems
  • Imbalance of good/bad bacteria.

What is a probiotic?

We coexist with millions of live bacteria and other microorganisms in and on our body, the majority living in our gut, but also on our skin, in our mouth and in our urinogenital system. These microorganisms are collectively known as the microbiota and we have evolved alongside these microbial communities in mutual benefit. Probiotic refer to bacteria that play an active health-promoting role and when in balance promotes health and wellness. However, a disturbance in the microbiota can cause an overgrowth of harmful microorganisms, resulting in disease and illness. A balanced gut microbiota is associated with a healthy immune system, healthy digestion and keeping inflammation and allergies at bay. An imbalance between probiotic and harmful bacteria is associated with type digestive disorders, inflammatory bowel disease 2 diabetes mellitus and cardiovascular1, 2, 3; also possibly some brain disorders like Alzheimer's disease and Parkinson's disease4, 5.

Why is the vaginal microbiota important?

The vaginal microbiota is a complex ecosystem and more than 200 bacterial species and include several species of lactobacilli that dominate the healthy vagina6, 7. These lactobacilli protect against microbial imbalance or dysbiosis which is caused by an overgrowth of harmful microbes. They do this by producing antibacterial chemicals such as defensins (antimicrobial peptides) and anti-inflammatory cytokines7, 8. They also produce hydrogen peroxide and lactic acid, which creates an acidic environment in the vagina that makes it impossible for many potentially harmful vaginal pathogens to grow9. Reduced numbers of probiotic bacteria resulting in dysbiosis can lead to health problems such as thrush, which is caused by the yeast Candida, and bacterial vaginosis, a common bacterial infection that is associated with an overgrowth of the bacteria Gardnerella vaginalis and Peptostreptococcus anaerobius. An imbalance in the vaginal microbiota is also associated with increased risk of sexually transmitted infections such as caused by the bacteria Chlamydia trachomatis and the protozoan trichomonas; also increased risk of obstetric complications, such as preterm birth10. Depleted lactobacillus probotics can be due to a variety of reasons including use of antibiotics, low oestrogen and high blood sugar.

Probiotics for vaginal health

The use of probiotics to treat and prevent vaginal infections like candidiasis and bacterial vaginosis has been the subject of several studies. The evidence provided by these studies indicates that oral probiotics are helpful in the treatment and prevention of bacterial vaginosis; also, in preventing recurrence, which antibiotic treatment has failed to do11, 12, 13. Studies have also demonstrated that oral probiotics can change vaginal microbiota, restoring a healthy balance14, 15. In a study where oral administration of Lactobacillus acidophilus, or a combination of Lactobacillus rhamnosus GR-1 and Lactobacillus fermentum RC-14, was used treat or prevent bacterial vaginosis, the disease was cured, or its recurrence reduced, and normal vaginal microbiota was restored16. In women of childbearing age, oestrogen helps maintain a normal vaginal microbiota. In postmenopausal women, decreased oestrogen levels deplete the vaginal lactobacilli, increase vaginal pH and increases risk of infections like candidiasis and bacterial vaginosis. Treatment with probiotics has been found effective in treating vaginal infection and restoring a healthy vaginal microbiota in menopausal women17.

What are the Ingredients of Flora Restore?

Ingredients: (per capsule)

Total Probiotic Bacteria: No less than 5billion CFU.

Consisting of:

Lactobacillus rhamnosus GR-1™  2.5 billion Colony Forming Units
Lactobacillus reuteri RC-14™ 2.5 billion Colony Forming Units

Lactobacillus rhamnosus and Lactobacillus reuteri:

Lactobacillus rhamnosus and Lactobacillus reuteri are predominant species of Lactobacillus in the vagina. Oral administration of a combination of Lactobacillus rhamnosus and Lactobacillus reuteri can effectively treat and prevent vaginal candidiasis and bacterial vaginosis. 18, 19, 20 Lactobacillus probiotics work by disrupting the biofilms that are formed as bacteria and candida yeast grow and inhibit the growth of these vaginal pathogens, which treats the infection, prevents recurrence and allows the vaginal microbiota balance to be restored21.

Formulation also contains:

Each capsule also contains microcrystalline cellulose, dextrose, potato starch and magnesium stearate. They may contain traces of milk products.

Formulation does not contain:

Gluten (or wheat), artificial colours, sweeteners, flavours or preservatives.

What are the Contraindications/Interactions of Flora Restore?

There are no documented contraindications or interactions within the recommended dosage. However, you should always check the ingredients for known allergies and to ensure you do not have any allergies or sensitivities to these ingredients. Stop using if you develop any irritation or allergy while taking Flora Restore. Always read the label and use as directed or seek advice from your healthcare professional.

What is the Dosage Recommendation for Flora Restore?

Adults:

Take one capsule daily with, before or after food. If required increase to two capsules, depending on your health professional’s recommendation.
If you are also taking an antibiotic or antifungal medication, you should use as directed by your doctor and take your Flora Restore capsule at least one hour after taking your medication.
You should continue to take your Flora Restore for as long as recommended by your healthcare professional.

Caution:

Flora Restore is considered suitable if you have a mild dairy intolerance and for use when pregnant or breastfeeding, however, if in doubt consult your health professional.
Do not use if you have a severe intolerance or allergy to dairy which includes Immunoglobulin (IgE) mediated dairy allergy or anaphylaxis, which is a potentially life-threatening reaction.

Product Size

30 Capsules

References

The following references provide scientific support for the use of this product:
  1. Clemente JC, Ursell LK, Parfrey LW, Knight R. The Impact of the Gut Microbiota on Human Health: An Integrative View. Cell 2012, 148 issue 6, 1258-70
  2. O’Hara AM, Shanahan F. The gut flora as a forgotten organ. EMBO Reports 2006, 207 7(7) 688-693.
  3. Cresci GA, Bawden E. Gut Microbiome: What We Do and Don't Know. Nutr Clin Pract 2015 Dec;30(6):734-46. 
  4. Pellegrini C, Antonioli L, Colucci R, Blandizzi C, Fornai M. Interplay among gut microbiota, intestinal mucosal barrier and enteric neuro-immune system: a common path to neurodegenerative diseases? Acta Neuropathol.2018 Sep;136(3):345-361. 
  5. Alam MZ, Alam Q, Kamal MA, Abuzenadah AM, Haque A. A possible link of gut microbiota alteration in type 2 diabetes and Alzheimer's disease pathogenicity: an update. CNS Neurol Disord Drug Targets.2014 Apr;13(3):383-90. Vaginal microbiota
  6. Mendling W. Vaginal Microbiota. Adv Exp Med Biol.2016;902:83-93. 
  7. Martin DH. The Microbiota of the Vagina and Its Influence on Women’s Health and Disease. Am J Med Sci. 2012; 343(1): 2–9. 
  8. Bertuccini L, Russo R, Iosi F, Superti F. Effects of Lactobacillus rhamnosus and Lactobacillus acidophilus on bacterial vaginalpathogens. Int J Immunopathol Pharmacol.2017 Jun;30(2):163-167. 
  9. Atassi F,Servin A L.(2010).Individual and co-operative roles of lacticacid and hydrogen peroxide in the killing activity of enteric strain Lactobacillus johnsonii NCC933 and vaginal strain Lactobacillus gasseri KS120.1 against enteric, uropathogenic andv aginosis-associated pathogens. FEMS Microbiol. Lett. 304,29–38.
  10. Gajer P, Brotman RM, Bai G, Sakamoto J, Schütte4 UME, et al. Temporal Dynamics of the Human Vaginal Microbiota. Sci Transl Med. 2012 May 2; 4(132): 132ra52
  11. Homayouni A, Bastani P, Ziyadi S, Mohammad-Alizadeh-Charandabi S, et al. Effects of probiotics on the recurrence of bacterial vaginosis: a review. J Low Genit Tract Dis.2014 Jan;18(1):79-86. 
  12. Barrons R, Tassone D. Use of Lactobacillus probiotics for bacterial genitourinary infections in women: a review. Clin Ther.2008 Mar;30(3):453-68.
  13. Russo R, Edu A, De Seta F. Study on the effects of an oral lactobacilli and lactoferrin complex in women with intermediate vaginal microbiota. Arch Gynecol Obstet.2018 Jul;298(1):139-145.
  14. Reid G. Has knowledge of the vaginal microbiome altered approaches to health and disease? F1000Res.2018 Apr 13;7:460. 
  15. Macklaim JM, Clemente JC, Knight R, Gloor GB, Reid G. Changes in vaginal microbiota following antimicrobial and probiotic therapy. Microb Ecol Health Dis.2015 Aug 14;26:27799. 
  16. Falagas M, Betsi GI, Athanasiou S. Probiotics for the treatment of women with bacterial vaginosis. Clin Microbiol Infect.2007 Jul;13(7):657-64.
  17. Kim JM, Park YJ. Probiotics in the Prevention and Treatment of Postmenopausal Vaginal Infections: Review Article. J Menopausal Med.2017 Dec;23(3):139-145. 
  18. Martinez RC, Seney SL, Summers KL, Nomizo A, De Martinis EC, Reid G. Effect of Lactobacillus rhamnosus GR-1 and Lactobacillus reuteri RC-14 on the ability of Candida albicans to infect cells and induce inflammation. Microbiol Immunol.2009 Sep;53(9):487-95. 
  19. Mu Q, Tavella VJ, Luo XM. Role of Lactobacillus reuteri in Human Health and Diseases. Front Microbiol. 2018; 9: 757.
  20. Vujic G, Jajac Knez A, Despot Stefanovic V, Kuzmic Vrbanovic V. Efficacy of orally applied probiotic capsules for bacterial vaginosis and other vaginal infections: a double blind randomized, placebo-controlled study. Eur J Obstet Gynecol Reprod Biol 2013; 168: 75-9.
  21. Cribby S, Taylor M, Reid G. Vaginal Microbiota and the Use of Probiotics. Interdiscip Perspect Infect Dis. 2008; 2008: 256490.