Go Healthy Go B Complex
What is Go B Complex?
Go B Complex is a dietary supplement containing a combination of all eight B vitamins in a single capsule. Go B Complex provides the full spectrum of B vitamins that are needed to support a healthy nervous system, promote mental clarity and provide the body with the energy needed for a healthy active lifestyle.
Why use Go B Complex?
Vitamins are essential nutrients needed by the body for general health and wellbeing, but they are not made by the body and can only be obtained from the diet. The B vitamin family play important roles in many essential physiological processes. These include energy production, cell growth and metabolism, red blood cell production, healthy brain and thyroid function. Vitamin B levels can be compromised by restrictive diets, some medications, conditions like gastrointestinal diseases that affect food absorption, and in some groups of people, such as older people and during pregnancy. Go B Complex is a dietary supplement containing a combination of all eight B vitamins in a single capsule, providing the full spectrum of B vitamins that are needed to support a healthy nervous system, promote mental clarity and provide the body with the energy needed for a healthy active lifestyle.
What are the Key Benefits of Go B Complex?
Vitamin B Complex includes a number of water soluble vitamins that are all closely related and share common characteristics. All of the B vitamins are very important as they are considered essential micro-nutrients that must be obtained to promote optimal health and well-being. The body requires all the B's and if you are low in one or any of them, then the others cannot perform their job.
Benefits:
- Provides the full spectrum of B vitamins in a single once a day capsule
- Supports normal levels of B vitamins in groups that are at risk of B vitamin deficiency
- Supports energy generation and metabolic processes
- Supports a healthy nervous system and healthy brain function
- Supports normal red blood cell production
- Promotes cell division and DNA synthesis and repair
- Supports healthy skin, immune and digestive systems
- Suitable for those with gastrointestinal problems
Uses:
Nervous System Support:
Provides optimal neurological functioning of the brain by promoting normal functioning of chemicals such as hormones and neurotransmitters in mental clarity and other higher mental functioning.
Energy Production:
Help to produce energy by breaking down the foods you eat into fuel that your body can use. Any deficiency of these B's affects the metabolic functioning of the cells which can lead to fatigue, weakness and irritability. Concentration and Memory: Vitamins B5 and B6 promote memory and concentration. They work by dissolving and neutralizing higher levels of homocysteine (natural by-product) that is toxic to brain health.
Digestive System:
Promotes digestive functioning of the body by stimulating the release of gastric acid. Any deficiency of Vitamin B1, B6 and B7 lead to impaired digestion and malabsorption of key dietary nutrients. Vitamin B6 helps to enhance the the absorption of other B vitamins.
Cardiovascular Diseases:
Vitamin B12 may help to lower homocysteine (an amino acid that is thought to increase the risk of heart disease when it is present in elevated levels).
Hair, Skin & Nail Health:
Most B vitamins are essential for growth and production of the superficial layers of skin, including hair and nails. A deficiency of B vitamins may lead to skin conditions such as dermatitis, psoriasis etc and pre-mature aging, graying of hair and dementia.
Healthy Pregnancy:
A deficiency of Vitamin B9 (Folate) presents a higher risk of neural tube defects in the baby so it is recommended that Pregnant women take at least 300mg of folate daily to minimize the risk of complications.
Morning Sickness:
When pregnant, the body requires extra micronutrients to help stabilize serum concentration of hormones and neurotransmitters.
Mental Wellness:
B complex vitamins promote mental well-being and may help to lower the risk of developing depression, anxiety, age related cognitive decline and memory decline.
Premenstrual Syndrome:
Vitamin B6 helps to control hormonal fluctuation thus reducing the the symptoms associated with premenstrual syndrome.
Vegan Health:
The only food sources of Vitamin B12 are animal foods, so this is one nutrient that is essential to supplement if you continue with a vegan diet.
What are the B Vitamins?
A vitamin is an organic compound and essential micronutrient that is needed in small amounts for healthy functioning of the body but is not synthesised by the body. The B vitamins are a family of water soluble vitamins that play important roles in many essential physiological processes and are needed for all aspects of cell growth and metabolism. Since they are water soluble, B vitamins are not stored by the body, therefore, B vitamins should be included in the diet on a daily basis1. B vitamins act as cofactors for an array of enzymes, many of which are involved in various aspects of metabolism including energy production, carbohydrate and fatty acid synthesis, DNA regulation and gene expression. Although each member of the B vitamin family has a specific role to play, their functions are closely interrelated so that it is important to maintain the required levels of each B vitamin to support all the physiological processes that support a healthy body. These include catabolic metabolism which is the breaking down of nutrient molecules (carbohydrates, proteins, fats) into smaller units (sugars, amino acids, fatty acids) that can be used to generate energy; and anabolic metabolism, which is the building up of new molecules from smaller units to be used as building blocks for cell structures (cell membranes, DNA, bone, muscle), using energy generated by the catabolic pathways.
What causes B vitamin deficiency?
The B vitamins work closely together to support all aspects of brain function and are important for normal cognitive function; deficiency of B vitamins is thought to contribute to cognitive impairment and decline2. Some B vitamins particularly support a healthy thyroid or immune system or specific areas of metabolism, and a deficiency in B vitamins can result in serious health conditions. Also, some situations increase the body’s demand for B vitamins, such as increasing age and pregnancy. B vitamin deficiency is usually caused by restricted diets like vegan or vegetarian, poor nutrition, alcohol abuse, gastrointestinal conditions that affect food absorption including coeliac disease, Chrohn’s disease and irritable bowel disorder; also other medical conditions such as neurological disorders, hypothyroidism and anorexia that can cause malabsorption. Some medication can cause deficiency in B vitamins such as isoniazid that lowers vitamin B6 levels, proton pump inhibitors like omeprazole can decrease the absorption of B12, while metformin can decrease levels of both B12 and B9 levels1, 3, 4, 5. Some of the B vitamins are heat stable (such as Niacin (B3) whereas most are destroyed during cooking at high temperatures such as thiamine (B1), also very few B vitamins are found in refined processed food and this can lead to deficiency in those with poor diets.
How the B vitamins work together?
Since the B vitamins are so important for many aspects of metabolism, it makes sense that they work together. On this basis and from evidence from clinical trials, it is recommended that vitamin B supplements contain the complete range of B vitamins1.
Energy generation
Energy that is needed to power all the body’s processes is generated from the food that we eat by a series of metabolic processes. This is known as cellular aerobic respiration and it takes place in the mitochondria, the energy generating factory within the cell. The metabolic pathways involved are the citric acid cycle (Krebs cycle) and the electron transport chain. The outcome of these reactions is the formation of adenosine triphosphate (ATP), which is how the body stores energy that can be released from the high energy phosphate bonds. Thiamine (B1), riboflavin (B2), niacin (B3), pantothenic acid (B5) and biotin (B7) all play a direct role as coenzymes in the citric acid cycle. A deficiency in just one of these B vitamins can affect the entire biochemical process for converting nutrients to energy. Glucose, derived from carbohydrates is the main substrate for the citric acid cycle, but energy can also be generated from amino acids and fatty acids via synthesis of acetyl coenzyme A (CoA), which then enters the citric acid cycle. This part of the energy generation process is dependent on B5 (Pantothenic Acid). Thiamine (B1), biotin (B7) and B12 (Cyanocobalamin) also play an essential role in metabolism of glucose, fatty acids and amino acids respectively1, 6, 7.
Protein and DNA synthesis
Several of the B vitamins are cofactors in two important metabolic (anabolic) cycles, the folate and methionine cycle, that result in the generation of amino acids for protein synthesis and nucleic acids for DNA and RNA synthesis. Homocysteine is an amino acid that is not used in protein synthesis but is an important intermediary metabolite in the metabolism and synthesis of the DNA bases purine and pyrimidine, and the amino acids methionine, glycine and serine. This is is known as one carbon metabolism, which is how carbon atoms are redistributed from certain amino acids (usually serine and glycine) to generate other amino acids (methionine from homocysteine) that are needed to support cell biosynthesis and production of important molecules such as the antioxidant glutathione. The closely interrelated folate cycle and methionine cycles are at the core of these metabolic processes, which are dependent on pyridoxine (B6), Folate (B9) and cobalamin (B12) as cofactors. A deficiency in any one of the B vitamins can result in a build up of intermediary metabolites like homocysteine, that are thought to contribute to increased risk of cardiovascular disease, dementia, Alzheimer’s disease, and impaired cognitive function1, 8, 9, 10.
What are the Ingredients of Go B Complex?
Each capsule of Go B Complex contains the following ingredients:
- Vitamin B1 (Thiamine) 110mg
- Vitamin B2 (Riboflavin) 110mg
- Vitamin B3 (Niacin) 100mg
- Vitamin B5 (Pantothenic Acid) 110mg
- Vitamin B6 (Pyridoxine ) 110mg
- Vitamin B7 (Biotin) 120mcg
- Vitamin B9 (Folic Acid) 300mcg
- Vitamin B12 (Cyanocobalamin) 50mcg
- Choline 55mg
- Inositol 55mg
Note:
- Does not contain sugar or artificial sweeteners
- Does not contain added colours, flavours, preservatives, gluten, wheat or dairy
Vitamin B1 (Thiamine)
Thiamine (B1) is found in moderate amounts in most foods particularly lean pork, beef, fish, whole grains, cereals, legumes, nuts and fortified breakfast cereals. The recommended daily intake (RDI) for adults over 18 is 1.2 mg/day for men and 1.1 mg/day for women. Thiamine is an essential cofactor for three enzyme systems in the metabolism of glucose for energy production11. Thiamine deficiency is usually due to poor diet, particularly in countries where the staple food is white rice, and can lead to decreased energy production, with symptoms including confusion, irritability, poor arm/leg coordination, lethargy, fatigue and muscle weakness. Some organs require more energy, including the brain and based on its pivotal role in cellular energy generation, thiamine is essential for cell viability, and particularly for proper neuronal functioning. Thiamine is also a coenzyme in the pentose phosphate pathway, which is an important step in the synthesis of fatty acids, steroids, nucleic acids, glutathione (a natural antioxidant) and neurotransmitters needed for normal brain function12. Thiamine deficiency contributes to neurodegenerative changes in the brain that are similar to those seen in Alzheimer’s disease, Parkinson’s disease, Huntington’s disease and the Wernicke–Korsakoff, a condition caused by alcohol abuse13.
Vitamin B2 (Riboflavin)
Vitamin B2 or riboflavin is found in eggs milk, lean meat, organ meats (liver, kidneys), leafy green vegetables, and legumes. The recommended daily intake (RDI) for adults over 18 is 1.1 mg/day for men and 1.3 mg/day for women, which should increase to 1.4mg during pregnancy. Two coenzymes derived from riboflavin (flavoproteins) are involved in most cellular enzymatic processes; flavin adenine mononucleotide (FMN) and flavin adenine dinucleotide (FAD). The flavoproteins are involved in energy production as FMN and FAD are coenzymes in the citric acid cycle. They also protect against oxidative stress by acting as cofactors in the glutathione reductase cycle, which generates a natural antioxidant that inhibits lipid peroxidation, a cause of cell damage, particularly in the brain14. The flavoproteins are also involved in the synthesis of all heme proteins, including haemoglobin, and in the absorption and utilisation of iron from the diet. A deficiency in riboflavin can alter iron metabolism, which can cause anaemia. Animal and clinical studies have indicated that supplementation with riboflavin can increase haemoglobin levels and improve the haematologic status1, 15. Flavoproteins participate in redox reactions (transfer of electrons), which are critical for many metabolic processes including energy generation via the mitochondrial respiratory electron transfer chain, oxygen transport and storage, metabolism of carbohydrates, lipids and proteins, fatty acid metabolism in the brain, and metabolism of toxins and drugs in conjunction with P450 enzymes. Brain cells have a particularly high metabolic rate and consume large amounts of energy; therefore, riboflavin plays a critical role in brain function due to its involvement in the electron transfer chain. The brain is also highly susceptible to oxidative damage and riboflavin has neuroprotective properties due to its involvement in antioxidant generation1, 16, 17, 18. Nitric oxide is an important cellular signalling molecule that is involved in many physiological processes including neurotransmission, vascular tone, hormone secretion, and its synthesis is catalysed by the enzyme nitric oxide synthase. Nitric oxide synthesis involves electron transfer, which is mediated by the flavoproteins1, 19. Flavoproteins are involved in the metabolism of other B vitamins; niacin (B3), folate (B9) and pyridoxine (B6)1.
Vitamin B3 (Niacin)
Vitamin B3 or niacin is found in meat, fish, poultry, nuts, legumes and grains. The main dietary form of niacin is nicotinamide or nicotinic acid and it can also be generated from the amino acid tryptophan. The recommended daily intake (RDI) for adults over 18 is 16mg/day for men and 14 mg/day for women, which should increase to 18mg during pregnancy. Niacin plays a major role in energy generation as it is an essential co-enzyme in mitochondrial aerobic respiration, due to its direct involvement in the citric acid cycle and electron transfer chain that generates ATP. Niacin is converted into its active forms nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NAD) in most tissues, particularly the brain which has high energy requirements, and tissues with high cell turnover, such as skin and gut. NAD and NADP are involved in many other metabolic processes including providing antioxidant protection, DNA synthesis and repair and cellular signalling. Niacin receptors (NIACR1 and NIACR2) are found in cells of the brain and nervous system, immune system and in adipose tissue (fat cells)1, 20. Clinical studies indicate that niacin improves the lipid profile in those at risk or atherosclerosis and cardiovascular disease by increasing HDL levels (high density lipoprotein cholesterol, “good cholesterol”)21, 22. Niacin may also have neuroprotective and anti-inflammatory effects, based on studies demonstrating reduced levels of niacin in patients with Parkinson’s disease23, and improved symptoms with niacin supplementation24.
Vitamin B5 (Pantothenic Acid)
Vitamin B5 or pantothenic acid is found in most foods but particularly beef, liver, poultry, nuts, legumes and grains. The recommended daily intake (RDI) for adults over 18 is 5mg/day for men and women, which should increase to 6mg during pregnancy. Pantothenic acid is essential for synthesis of coenzyme A (CoA), which plays a central role in many biological processes including the synthesis and oxidation of fatty acids for energy production and synthesis of cholesterol, amino acids and phospholipids, which are important for cell membranes1, 25. Pantothenic acid is also involved in the synthesis of several neurotransmitters like acetylcholine, steroid hormones like the stress hormone cortisol26, and heme, a component of haemoglobin needed for normal red blood cell function. CoA is also involved in the detoxification process that takes place in the liver. Vitamin B5 is thought to be important in moderating the stress response1.
Vitamin B6 (pyridoxine)
Vitamin B6 or pyridoxine is found in meat, fish, poultry, starchy vegetables like potatoes, some fruit (except citrus) like bananas, and chickpeas. The recommended daily intake (RDI) for adults over 18 is 1.3mg/day for men and women, which should increase to 1.7mg during pregnancy and to 1.5-1.7mg for those over 50 years. Like all members of the vitamin B group pyridoxine is a cofactor for many enzymes that perform many metabolic functions throughout the body and is important for energy production, immune function and formation of red blood cells. Pyridoxine Pyridoxal 5’ phosphate (PLP) and pyridoxamine 5’ phosphate (PMP) are the active coenzyme forms of vitamin B6. Pyridoxine is an essential cofactor in the folate/methionine cycle and is an important mediator in amino acid metabolism. The synthesis of several neurotransmitters is dependent on pyridoxine, including dopamine that regulates attention, learning, and emotional responses; serotonin that regulates mood; and gamma aminobutyric acid (GABA) the major inhibitory neurotransmitter. Pyridoxine is also important for synthesis of hormones including melatonin and thyroid hormone1. A deficiency of pyridoxine can result in behavioural and sleep disorders1, and supplementation with vitamin B6 may improve symptoms of thyroid disease27. There is some clinical evidence to suggest a link between vitamin B6 deficiency and physical symptoms of premenstrual syndrome (PMS) as well as hormone related depression associated with PMS, and that supplementation with vitamin B6 may help relieve symptoms of PMS28, 29, 30. Pyridoxine is also involved in immune function and inflammation and there may be a relationship between levels of PLP in the blood and inflammatory/immune related conditions and also in cognitive decline in the elderly1, 31. Pyridoxine is involved in preventing increased levels of homocysteine, thereby reducing risk for impaired cognition, dementia and Alzheimer’s disease in the elderly32. Outcomes of a study in the elderly with mild cognitive impairment and increased risk of Alzheimer’s disease indicated that supplementation with B vitamins including B6 may slow the progression of the disease33.
Vitamin B7 (Biotin)
Biotin or vitamin B7 is found in liver, meat, fish, eggs, seeds, nuts, some vegetables like sweet potato, broccoli and spinach. The recommended daily intake (RDI) for adults over 18 is 30mg/day for men and women. Biotin is an essential cofactor for five different carboxylase enzyme that are involved in metabolic pathways for fatty acid synthesis, glucose metabolism (citric acid cycle) and amino acid metabolism1, 34, 35. Biotin is an essential factor for synthesis of keratin, an integral structural protein of hair, skin and nails. Deficiency of Biotin results in dermatitis, which is thought to be due to impaired fatty acid metabolism, and in hair loss due to insufficient keratin synthesis. Supplementation with biotin is thought to improve condition of hair, skin and nails in cases of biotin deficiency36, 37, 38. Biotin also plays an important role in regulation of gene expression by binding to histones (a DNA binding protein that regulates gene expression) which mediates gene regulation. This role of biotin has been linked to regulation of glucose and lipid metabolism1, 34, 35.
Vitamin B9 (Folic Acid)
Vitamin B9 or folate is found in green leafy vegetables, legumes, seeds, liver, poultry, eggs, cereals and citrus fruit. Folate is the generic term for the naturally occurring form of vitamin B9 but folic acid is the form of vitamin B9 commonly used in supplements and fortified foods. The recommended daily intake (RDI) for adults over 18 is 400mcg, which should increase to 600mcg during pregnancy. The main role of folate is in the synthesis of nucleic acids (DNA and RNA) and in amino acid metabolism. It has been known for some time that folate is critical for normal development of the foetal nervous system, and supplementation is now recommended in the early stages of pregnancy, starting before conception and into the first three months of pregnancy, to prevent neural tube defects like spina bifida. Folate is essential for methylation, which is a biochemical reaction linked to the methionine cycle and involved in gene expression, which is important to normal neural tube development. Methylation is also essential for normal cell division, and in cells that are rapidly dividing like red and white blood cells. A deficiency in folate can result in megaloblastic anaemia, due to impaired red blood cell production1, 9. The folate/methionine cycles, which need folate (B9) and cobalamin (B12) as cofactors, take homocysteine and convert it to methionine, an amino acid used in many biological processes. The enzyme dihydrofolate reductase is produced as an output of the folate cycle and is a rate limiting step in the overall process, as well as other enzymes like methionine synthase reductase needed for the recycling of the vitamin B121. A deficiency in either of these B vitamins can lead to a build up of homocysteine. Several clinical studies have found a link between low levels of folate and high levels of homocysteine and decline in cognitive function, dementia and Alzheimer’s disease39, 40. The mechanisms for this include reduced DNA stability, impairment of nerve cell differentiation and repair, demyelination (damage to the protective myelin sheath surrounding nerve fibres) resulting in impaired nerve transmission, oxidative stress, cell death, accumulation of the brain destructive beta-amyloid peptide, which also impairs neuronal transmission and causes nerve cell damage40. Clinical studies indicate that supplementation with folic acid increases blood folate levels and decreases homocysteine levels with a significant improvement in cognitive function40, 41, 42. An association between between low levels of folate and high levels of homocysteine is indicated for increasing risk of cardiovascular disease. Outcomes of clinical studies using supplementation with folic acid indicated reduced risk of stroke associated with cardiovascular disease43, 44.
Vitamin B12 (Cyanocobalamin)
Vitamin B12 is found mainly in animal foods including fish, meat, eggs and milk, but is scarce in plant based foods. It contains a cobalt molecule in its structure and is also known as cobalamin and there are naturally two active forms which are methylcobalamin and 5-deoxyadenosylcobalamin. Cyanocobalamin is a synthetic form of vitamin B12 that is only found is supplements, as it more stable, but it is not found in nature and is converted into methylcobalamin or 5-deoxyadenosylcobalamin once ingested. The recommended daily intake (RDI) for adults over 18 is 2.4mcg, which should increase to 2.6mcg during pregnancy. Vitamin B12 is transported bound to protein first in the saliva and then to a glycoprotein called intrinsic factor produced by the parietal cells of the gastric mucosa, which is essential for absorption of vitamin B12 from the small intestine into the circulation. B12 also circulates in the blood bound to a protein called transcoalbumin45. The role of vitamin B12 is very closely linked with folate (B9) as they are both essential cofactors for metabolic processes of the folate/methionine cycles that generate precursors for protein and nucleic acid (DNA, RNA) synthesis1. Vitamin B12 and B9 are both intricately involved in homocysteine metabolism from which the amino acid methionine is generated1. Elevated levels of homocysteine due to a deficiency of B7 or B12, or a metabolic dysfunction can result in health issues such as impaired nervous system and cognitive function, abnormal red blood cell formation, foetal neural tube defects and increased risk of pregnancy complications46, 47. B12 deficiency at a subclinical level is common in the elderly and clinical studies indicate that this contributes to cognitive decline, particularly in the elderly and is also associated with other age-related chronic diseases45. A correlation between thyroid hormone levels and increased levels of homocysteine are thought to contribute to hypothyroidism. Clinical studies indicate a role for vitamin B12 in regulating thyroid hormone levels48, 49. Outcomes of clinical studies indicate that deficiency in vitamin B12 is associated with thyroid dysfunction in patients with autoimmune thyroid disease50.
Choline
Choline is an essential water soluble nutrient that must be obtained from the diet and is often associated with the B vitamins, however, it is not officially defined as a B vitamin. Choline is found in meat, poultry, fish, eggs, some vegetables like broccoli and cauliflower, and some beans. Choline plays an important role in the synthesis of phosphatidylcholine a major phospholipid needed for normal structure and function of all cell membranes, providing structural integrity as well as being important in cell signalling. Choline is also a precursor for sphingomyelin, another important phospholipid that is a major component of the myelin sheath that protects nerve axons, which are the fibres that transmit information between nerve cells. Choline is also a precursor for the neurotransmitter acetylcholine which plays an important role in memory, mood, muscle control, and other brain and nervous system functions. Choline is also involved in the methionine cycle that results in the generation of amino acids for protein synthesis and nucleic acids for DNA and RNA synthesis51. Choline has neuroprotective properties as demonstrated in several animal and clinical studies, and studies indicate that choline supports a healthy nervous system in foetal development and also supports cognitive function in adult life. Choline deficiency and loss of cholinergic function are associated with development of Alzheimer’s disease51, 52. Choline also plays an important role in healthy liver function53.
Inositol
Inositol is sometimes referred to as vitamin B8 but is a sugar that exists mainly in the form of myoinositol. Inositol is found in grains, legumes and nuts but is also synthesised from glucose in several tissues mainly the kidneys and is present in the highest concentration in the brain. Inositol is incorporated into all cell membranes as phosphatidylinositol, which is an important structural component and is involved in cell signalling54. Inositol is also a precursor for second messengers in many metabolic pathways such as regulating hormones including thyroid-stimulating hormone (TSH), follicle-stimulating hormone (FSH) and insulin. Inositol is a precursor for synthesis of neurotransmitters such as acetylcholine, serotonin and dopamine, and is important in regulating mood, cognitive function and mental health55, 56, 57. Clinical studies have indicated that supplementation with inositol may be helpful for metabolic disorders relating to insulin resistance including polycystic ovary syndrome (PCOS), gestational diabetes mellitus and metabolic syndrome58.
What are the Contraindications/Interactions of Go B Complex?
You should always check the ingredients for known allergies and to ensure you do not have any allergies or sensitivities to these ingredients. Stop using if you develop any irritation or allergy while taking Go B Complex. Always read the label and use as directed or seek advice from your healthcare professional.
Caution:
You should consult your healthcare professional if you are taking any prescription medication before taking Go B Complex, as some medications may interfere with absorption of B vitamins.
What is the Dosage Recommendation for Go B Complex?
Adults Dosage:
Take one VegeCapsule of Go B Complex once daily in the morning and with food. If taken on an empty stomach the high doses of vitamin B in Go B Complex may cause nausea. If taken at night, Go B Complex may interfere with sleep.
Note:
You may notice your urine turns a bright yellow colour. This is normal as any excess B vitamins are excreted in the urine and vitamin B2 (riboflavin) interacts with urine forming the bright yellow colour.
Product Size
30 Capsules
References
The following references provide scientific support for the use of this product:
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